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Biology and Biochemistry

D-Index
55
Citations
14084
World Ranking
14858
National Ranking
6216

Overview

Joseph A. Mancini is affiliated with MSD in the United States and has contributed to a range of research publications primarily in the fields of Biochemistry, Genetics and Molecular Biology, as well as Neuroscience.

Their research spans several subfields including Molecular Biology, Cellular and Molecular Neuroscience, Genetics, Hematology, and Cancer Research. Key topics addressed in their work encompass Neuropeptides and Animal Physiology, Blood Coagulation and Thrombosis Mechanisms, Coagulation, Bradykinin, Polyphosphates, and Angioedema, Protease and Inhibitor Mechanisms, CRISPR and Genetic Engineering, Axon Guidance and Neuronal Signaling, and Neuroinflammation and Neurodegeneration Mechanisms.

Joseph A. Mancini has published in various scientific venues with a diversity of focus areas. Frequent publication venues include:

  • Communications Biology
  • European Journal of Cancer
  • Biomedicine & Pharmacotherapy
  • Journal of Biological Chemistry
  • Bioorganic & Medicinal Chemistry Letters

The following represents a selection of recent papers authored or coauthored by Joseph A. Mancini:

  • The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects (2020) - Communications Biology
  • 513LBA (PB-513) LBA Posters: BCCA7693 - A novel, orally bioavailable DNA-PK inhibitor demonstrates efficacy with targeted MAPK and PARP therapeutics by slowing the development of acquired resistance (2024) - European Journal of Cancer
  • Disruption of Plexin-A1 signaling by FTX-101: mode of action and effect on oligodendrocyte biology (2025) - Biomedicine & Pharmacotherapy
  • Interactome of FMRP-N-tat therapeutic unveils key interactions for cellular function in Fragile X neurons (2025) - Journal of Biological Chemistry
  • Design of a peripherally biased NPSR1 antagonist for neuropeptide S induced inflammation (2025) - Bioorganic & Medicinal Chemistry Letters

Joseph A. Mancini collaborates frequently with several coauthors across different projects. Notable frequent coauthors include:

  • Kévin Leguay
  • Oliver A. Kent
  • Claudio F. Sturino
  • Benny K. K. Chan
  • Charlotte Avet

Best Publications

  • Expression of Prostaglandin G/H Synthase-1 and -2 Protein in Human Colon Cancer

    Stacia L. Kargman;Gary P. O'Neill;Philip J. Vickers;Jilly F. Evans

  • Characterization of prostaglandin G/H synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts

    S Kargman;S Charleson;M Cartwright;J Frank

  • Identification and isolation of a membrane protein necessary for leukotriene production

    Douglas K. Miller;John W. Gillard;Philip J. Vickers;Sharon Sadowski

  • Etoricoxib (MK-0663): Preclinical Profile and Comparison with Other Agents That Selectively Inhibit Cyclooxygenase-2

    D Riendeau;M D Percival;C Brideau;S Charleson

  • The discovery of rofecoxib, [MK 966, VIOXX®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitor

    P Prasit;Z Wang;C Brideau;C.-C Chan

  • Rofecoxib [Vioxx, MK-0966; 4-(4′-Methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: A Potent and Orally Active Cyclooxygenase-2 Inhibitor. Pharmacological and Biochemical Profiles

    Chan Cc;Boyce S;Brideau C;Charleson S

  • Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism.

    Per-Johan Jakobsson;Ralf Morgenstern;Joseph Mancini;Anthony Ford-Hutchinson

  • Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor.

    D Riendeau;M D Percival;S Boyce;C Brideau

  • Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach.

    C C Chan;S Boyce;C Brideau;A W Ford-Hutchinson

  • Carrageenan-induced Paw Edema in Rat Elicits a Predominant Prostaglandin E2 (PGE2) Response in the Central Nervous System Associated with the Induction of Microsomal PGE2 Synthase-1

    Jocelyne Guay;Kevin Bateman;Robert Gordon;Joseph Mancini

  • Cloning, expression, and up-regulation of inducible rat prostaglandin E synthase during lipopolysaccharide-induced pyresis and adjuvant-induced arthritis

    Joseph A. Mancini;Katherine Blood;Jocelyne Guay;Robert Gordon

  • 5‐lipoxygenase‐activating protein is an arachidonate binding protein

    Joseph A. Mancini;Mark Abramovitz;Martha E. Cox;Elizabeth Wong

  • Identification and Characterization of a Novel Human Microsomal Glutathione S-Transferase with Leukotriene C4 Synthase Activity and Significant Sequence Identity to 5-Lipoxygenase-activating Protein and Leukotriene C4 Synthase

    Per-Johan Jakobsson;Joseph A. Mancini;Anthony W. Ford-Hutchinson

  • Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis

    G. K. Reid;S. Kargman;P. J. Vickers;J. A. Mancini

  • Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model

    David Claveau;Mirna Sirinyan;Jocelyne Guay;Robert Gordon

  • Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays

    Denis Riendeau;Stella Charleson;Wanda Cromlish;Joseph A. Mancini

  • Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily.

    Per-Johan Jakobsson;Ralf Morgenstern;Joseph Mancini;Anthony Ford-Hutchinson

  • Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities.

    Per-Johan Jakobsson;Joseph A. Mancini;Denis Riendeau;Anthony W. Ford-Hutchinson

  • MF63 {2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile}, a selective microsomal prostaglandin E synthase 1 inhibitor, relieves pyresis and pain in preclinical models of inflammation

    Daigen Xu;Steven E. Rowland;Patsy Clark;André Giroux

  • Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.

    Denis Riendeau;Renee Aspiotis;Diane Ethier;Yves Gareau

Frequent Co-Authors

Denis Riendeau
Denis Riendeau MSD (United States)
Anthony W. Ford-Hutchinson
Anthony W. Ford-Hutchinson Independent Scientist / Consultant, US
Robert N. Young
Robert N. Young Simon Fraser University
Donald W. Nicholson
Donald W. Nicholson MSD (United States)
Brian P. Kennedy
Brian P. Kennedy MSD (United States)
Ralf Morgenstern
Ralf Morgenstern Karolinska Institute
Robert Zamboni
Robert Zamboni MSD (United States)
Pierre Borgeat
Pierre Borgeat Université Laval
Bengt Samuelsson
Bengt Samuelsson Karolinska Institute
Daniel Guay
Daniel Guay Institut National de la Recherche Scientifique

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