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Jesper Z. Haeggström

Jesper Z. Haeggström

D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
14851
World Ranking
9657
National Ranking
135

Overview

Jesper Z. Haeggström is affiliated with the Karolinska Institute in Sweden and has contributed to research primarily within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine.

Their work spans several subfields, including Molecular Biology, Pharmacology, Immunology, Physiology, and Biochemistry. The main topics addressed in their research involve:

  • Asthma and respiratory diseases
  • Eicosanoids and Hypertension Pharmacology
  • Immune cells in cancer
  • Adipokines, Inflammation, and Metabolic Diseases
  • Endoplasmic Reticulum Stress and Disease
  • Pharmacogenetics and Drug Metabolism
  • Inflammatory mediators and NSAID effects

Jesper Z. Haeggström has published notable papers such as:

  • Structures of Leukotriene Biosynthetic Enzymes and Development of New Therapeutics, 2022, The Annual Review of Pharmacology and Toxicology
  • Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis, 2021, Nature Communications
  • Human leukocytes selectively convert 4 S,5 S-epoxy-resolvin to resolvin D3, resolvin D4, and a cys-resolvin isomer, 2021, Proceedings of the National Academy of Sciences
  • The Atlas of Inflammation Resolution (AIR), 2020, Molecular Aspects of Medicine
  • Activation of metabolite receptor GPR91 promotes platelet aggregation and transcellular biosynthesis of leukotriene C4, 2020, Journal of Thrombosis and Haemostasis

Their frequent co-authors include:

  • Charles N. Serhan
  • Tarvi Teder
  • Madhuranayaki Thulasingam
  • Xiao Tang
  • Oliver Werz

Jesper Z. Haeggström frequently publishes in venues such as:

  • Molecular Aspects of Medicine
  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • The Annual Review of Pharmacology and Toxicology

Best Publications

  • Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

    Dmitry Usoskin;Alessandro Furlan;Saiful Islam;Hind Abdo

  • Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease.

    Jesper Z. Haeggström;Colin D. Funk

  • Lipid mediator networks in cell signaling: update and impact of cytokines.

    Charles N. Serhan;Jesper Z. Haeggström;Christina C. Leslie

  • Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation.

    Marjolein M.G.M. Thunnissen;Pär Nordlund;Jesper Z. Haeggström

  • The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype

    Jesmond Dalli;Min Zhu;Nikita A. Vlasenko;Bin Deng

  • Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid

    Anders Hansson;Charles N. Serhan;Jesper Haeggström;Magnus Ingelman-Sundberg

  • Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability.

    Hong Qiu;Anders Gabrielsen;Hanna E. Agardh;Min Wan

  • Leukotriene A4 Hydrolase/Aminopeptidase, the Gatekeeper of Chemotactic Leukotriene B4 Biosynthesis

    Jesper Z. Haeggström

  • Structural Basis for Synthesis of Inflammatory Mediators by Human Leukotriene C4 Synthase.

    Daniel Martinez Molina;Anders Wetterholm;Andreas Kohl;Andrew A. McCarthy

  • Human endothelial cells stimulate leukotriene synthesis and convert granulocyte released leukotriene A4 into leukotrienes B4, C4, D4 and E4.

    Hans-Erik Claesson;Jesper Haeggström

  • Leukotriene A4 hydrolase: an epoxide hydrolase with peptidase activity.

    Jesper Z. Haeggström;Anders Wetterholm;Anders Wetterholm;Bert L. Vallee;Bert L. Vallee;Bengt Samuelsson;Bengt Samuelsson

  • Antimicrobial peptide LL-37 promotes bacterial phagocytosis by human macrophages.

    Min Wan;Anne M. van der Does;Xiao Tang;Lennart Lindbom

  • Leukotriene A4 hydrolase: a zinc metalloenzyme.

    Jesper Z. Haeggström;Anders Wetterholm;Robert Shapiro;Bert L. Vallee

  • Molecular cloning of a 12-lipoxygenase cDNA from rat brain

    Takashi Watanabe;Juan F. Medina;Jesper Z. Haeggström;Olof Rådmark

  • Leukotriene A4 hydrolase: determination of the three zinc-binding ligands by site-directed mutagenesis and zinc analysis.

    Juan F. Medina;Anders Wetterholm;Olof Radmark;Robert Shapiro

  • The leukotrienes: immune-modulating lipid mediators of disease.

    Antonio Di Gennaro;Jesper Z. Haeggström

  • Advances in eicosanoid research, novel therapeutic implications.

    Jesper Z. Haeggström;Agnes Rinaldo-Matthis;Craig E. Wheelock;Anders Wetterholm

  • Transcellular conversion of endogenous arachidonic acid to lipoxins in mixed human platelet-granulocyte suspensions.

    Charlotte Edenius;Jesper Haeggström;Jan Åke Lindgren

  • The Atlas of Inflammation Resolution (AIR).

    Charles N. Serhan;Shailendra K. Gupta;Mauro Perretti;Catherine Godson

  • Enzymes and receptors in the leukotriene cascade

    J Z Haeggström;A Wetterholm

Frequent Co-Authors

Bengt Samuelsson
Bengt Samuelsson Karolinska Institute
Olof Rådmark
Olof Rådmark Karolinska Institute
Craig E. Wheelock
Craig E. Wheelock Karolinska Institute
Charles N. Serhan
Charles N. Serhan Brigham and Women's Hospital
Mats Hamberg
Mats Hamberg Karolinska Institute
Sven-Erik Dahlén
Sven-Erik Dahlén Karolinska Institute
Chi-Huey Wong
Chi-Huey Wong Scripps Research Institute
Martin J. Mueller
Martin J. Mueller University of Würzburg
Ralf Morgenstern
Ralf Morgenstern Karolinska Institute
Göran K. Hansson
Göran K. Hansson Karolinska University Hospital

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