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Ralf Morgenstern

Ralf Morgenstern

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
14340
World Ranking
12416
National Ranking
183

Overview

Ralf Morgenstern is primarily affiliated with the Karolinska Institute in Sweden and has contributed significantly to the field of Biochemistry, Genetics, and Molecular Biology. Their research encompasses a range of topics with a focus on molecular mechanisms related to cancer, enzyme function, and cellular stress responses.

The main topics of Ralf Morgenstern's work include:

  • Glutathione Transferases and Polymorphisms
  • Genomics, phytochemicals, and oxidative stress
  • Epigenetics and DNA Methylation
  • Ferroptosis and cancer prognosis
  • Inflammatory mediators and NSAID effects
  • Estrogen and related hormone effects
  • Eicosanoids and Hypertension Pharmacology

These topics relate closely to their primary subfields of study, which include:

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Pharmacology
  • Genetics
  • Biochemistry

Ralf Morgenstern has published extensively, with key papers appearing in various respected venues. Some notable recent publications are:

  • "Microsomal glutathione transferase 1 in cancer and the regulation of ferroptosis," 2023, Advances in cancer research
  • "Microsomal glutathione transferase 1 controls metastasis and therapeutic response in melanoma," 2023, Pharmacological Research
  • "SAT0315 INHIBITION OF MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES-1) BY GS-248 REDUCES PROSTAGLANDIN E2 BIOSYNTHESIS WHILE INCREASING PROSTACYCLIN IN HUMAN SUBJECTS," 2020, Annals of the Rheumatic Diseases
  • "A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression," 2023, Journal of Biological Chemistry
  • "Enzymology of reactive intermediate protection: kinetic analysis and temperature dependence of the mesophilic membrane protein catalyst MGST1," 2023, FEBS Journal

Their frequent coauthors include:

  • Jie Zhang
  • Zhiwei Ye
  • Danyelle M. Townsend
  • Kenneth D. Tew
  • Paramita Chakraborty

Ralf Morgenstern's work spans various publication venues with notable appearances in:

  • Advances in cancer research
  • Pharmacological Research
  • Annals of the Rheumatic Diseases
  • Journal of Biological Chemistry
  • FEBS Journal

Their research has focused on biochemical pathways involving glutathione transferases, particularly microsomal glutathione transferase 1 (MGST1), and its roles in cancer progression, metastasis, and enzyme regulation. Studies investigating the enzyme's function in ferroptosis and oxidative stress mechanisms highlight a combination of biochemical, genetic, and pharmacological approaches.

By examining prostaglandin synthesis and its modulation, they have also contributed to understanding inflammatory mediators and their roles in disease contexts, touching upon the pharmacological implications of nonsteroidal anti-inflammatory drugs (NSAIDs).

This body of work positions Ralf Morgenstern within a multidisciplinary framework bridging molecular biology, genetics, and pharmacology, addressing complex biological systems relevant to health and disease.

Best Publications

  • The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease

    Hiroyuki Kobori;Masaomi Nangaku;L. Gabriel Navar;Akira Nishiyama

  • Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target

    Per-Johan Jakobsson;Staffan Thorén;Ralf Morgenstern;Bengt Samuelsson

  • NOMENCLATURE FOR HUMAN GLUTATHIONE TRANSFERASES

    B Mannervik;Y C Awasthi;P G Board;J D Hayes

  • Membrane Prostaglandin E Synthase-1: A Novel Therapeutic Target

    Bengt Samuelsson;Ralf Morgenstern;Per-Johan Jakobsson

  • Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism.

    Per-Johan Jakobsson;Ralf Morgenstern;Joseph Mancini;Anthony Ford-Hutchinson

  • Oxidative stress, human genetic variation, and disease.

    Lena Forsberg;Ulf de Faire;Ralf Morgenstern

  • A common functional C-T substitution polymorphism in the promoter region of the human catalase gene influences transcription factor binding, reporter gene transcription and is correlated to blood catalase levels.

    Lena Forsberg;Louise Lyrenäs;Ralf Morgenstern;Ulf de Faire

  • Microsomal glutathione S-transferase. Purification, initial characterization and demonstration that it is not identical to the cytosolic glutathione S-transferases A, B and C.

    Ralf Morgenstern;Claes Guthenberg;Joseph W. Depierre

  • Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily.

    Per-Johan Jakobsson;Ralf Morgenstern;Joseph Mancini;Anthony Ford-Hutchinson

  • Human Microsomal Prostaglandin E Synthase-1 PURIFICATION, FUNCTIONAL CHARACTERIZATION, AND PROJECTION STRUCTURE DETERMINATION

    Staffan Thorén;Rolf Weinander;Sipra Saha;Caroline Jegerschöld

  • The distribution of microsomal glutathione transferase among different organelles, different organs, and different organisms.

    Ralf Morgenstern;Gerd Lundqvist;Göran Andersson;Lennart Balk

  • Structural basis for induced formation of the inflammatory mediator prostaglandin E2

    Caroline Jegerschöld;Sven-Christian Pawelzik;Pasi Purhonen;Priyaranjan Bhakat

  • Reactive Intermediates and The Dynamics of Glutathione Transferases

    Rosanna Rinaldi;Erik Eliasson;Stellan Swedmark;Ralf Morgenstern

  • Interactions between Glutathione S-Transferase P1, Tumor Necrosis Factor, and Traffic-Related Air Pollution for Development of Childhood Allergic Disease

    Erik Melen;Fredrik Nyberg;Cecilia M. Lindgren;Niklas Berglind

  • Microsomal glutathione transferase. Primary structure.

    R Morgenstern;J W DePierre;H Jörnvall

  • Bioinformatic and enzymatic characterization of the MAPEG superfamily

    Anders Bresell;Rolf Weinander;Gerd Lundqvist;Haider Raza

  • Structural basis for detoxification and oxidative stress protection in membranes.

    Peter J. Holm;Priyaranjan Bhakat;Caroline Jegerschöld;Nobuhiko Gyobu

  • Evidence that rat liver microsomal glutathione transferase is responsible for glutathione-dependent protection against lipid peroxidation.

    Erifili Mosialou;Gunilla Ekström;Anton E.P. Adang;Ralf Morgenstern

  • Human glutathione dependent prostaglandin E synthase: gene structure and regulation

    Lena Forsberg;Lisa Leeb;Staffan Thorén;Ralf Morgenstern

  • Nanoparticle-directed sub-cellular localization of doxorubicin and the sensitization breast cancer cells by circumventing GST-mediated drug resistance.

    Xianghui Zeng;Ralf Morgenstern;Andreas M. Nyström

Frequent Co-Authors

Per-Johan Jakobsson
Per-Johan Jakobsson Karolinska University Hospital
Joseph W. DePierre
Joseph W. DePierre Stockholm University
Ulf de Faire
Ulf de Faire Karolinska Institute
Richard N. Armstrong
Richard N. Armstrong Vanderbilt University
Bengt Samuelsson
Bengt Samuelsson Karolinska Institute
Alicja Wolk
Alicja Wolk Karolinska Institute
Yoshinori Fujiyoshi
Yoshinori Fujiyoshi Nagoya University
Jesper Z. Haeggström
Jesper Z. Haeggström Karolinska Institute
Hiroshi Abe
Hiroshi Abe Nagoya University
Joseph A. Mancini
Joseph A. Mancini MSD (United States)

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