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Bengt Mannervik

Bengt Mannervik

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Biology and Biochemistry
Sweden
2023

D-Index & Metrics

Chemistry

D-Index
92
Citations
47685
World Ranking
1837
National Ranking
26

Biology and Biochemistry

D-Index
92
Citations
46883
World Ranking
2165
National Ranking
39

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Sweden Leader Award

Overview

Bengt Mannervik is a researcher affiliated with Stockholm University in Sweden. Their work predominantly spans the field of Biochemistry, Genetics, and Molecular Biology with a primary focus on Molecular Biology. Additional areas of study include Pharmacology, Public Health, Environmental and Occupational Health, Genetics, and Neurology.

The research topics covered by Mannervik include:

  • Glutathione Transferases and Polymorphisms
  • Genomics, phytochemicals, and oxidative stress
  • Pharmacogenetics and Drug Metabolism
  • Epigenetics and DNA Methylation
  • Research on Leishmaniasis Studies
  • Estrogen and related hormone effects
  • Cholinesterase and Neurodegenerative Diseases

Mannervik has published extensively, with notable recent papers such as:

  • "Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity" (2022) in Neural Regeneration Research
  • "Interactions Between Odorants and Glutathione Transferases in the Human Olfactory Cleft" (2020) in Chemical Senses
  • "Neuroprotection against Aminochrome Neurotoxicity: Glutathione Transferase M2-2 and DT-Diaphorase" (2022) in Antioxidants
  • "A Preclinical Model for Parkinson's Disease Based on Transcriptional Gene Activation via KEAP1/NRF2 to Develop New Antioxidant Therapies" (2023) in Antioxidants
  • "Glutathione Transferases as Efficient Ketosteroid Isomerases" (2021) in Frontiers in Molecular Biosciences

Frequent collaborators in their research include Aram Ismail, B. Sjödin, Juan Segura-Aguilar, Helena Lindström, and Yaman Muşdal. Mannervik's work appears regularly in venues such as Antioxidants, Biomolecules, Processes, bioRxiv (Cold Spring Harbor Laboratory), and Neural Regeneration Research.

Best Publications

  • Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver.

    Maria S. Moron;Joseph W. Depierre;Bengt Mannervik

  • [59] Glutathione reductase

    Inger Carlberg;Bengt Mannervik

  • Purification and characterization of the flavoenzyme glutathione reductase from rat liver.

    I Carlberg;B Mannervik

  • Glutathione transferases--structure and catalytic activity.

    B Mannervik;U H Danielson

  • The Isoenzymes of Glutathione Transferase

    Bengt Mannervik

  • Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties.

    B Mannervik;P Alin;C Guthenberg;H Jensson

  • NOMENCLATURE FOR HUMAN GLUTATHIONE TRANSFERASES

    B Mannervik;Y C Awasthi;P G Board;J D Hayes

  • Glutathione transferase (human placenta).

    Bengt Mannervik;Claes Guthenberg

  • Detoxication of base propenals and other alpha, beta-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases.

    Kiflu Berhane;Mikael Widersten;Ake Engstrom;John W. Kozarich

  • Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes.

    I. Sinning;G. J. Kleywegt;S. W. Cowan;P. Reinemer

  • 4-Hydroxyalk-2-enals are substrates for glutathione transferase

    Per Ålin;U.Helena Danielson;Bengt Mannervik

  • Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes

    Sofia Baez;Juan Segura-Aguilar;Mikael Widersten;Ann-Sofie Johansson

  • Human glutathione transferase A4-4: an Alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation

    Ina Hubatsch;Marianne Ridderström;Bengt Mannervik

  • Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons.

    Kathrin Sundberg;Anne Sofie Johansson;Gun Stenberg;Mikael Widersten

  • Binary combinations of four protein subunits with different catalytic specificities explain the relationship between six basic glutathione S-transferases in rat liver cytosol.

    B Mannervik;H Jensson

  • Nomenclature for mammalian soluble glutathione transferases.

    Bengt Mannervik;Philip G. Board;John D. Hayes;Irving Listowsky

  • Design and evolution of new catalytic activity with an existing protein scaffold.

    Hee Sung Park;Sung Hun Nam;Jin Kak Lee;Chang No Yoon

  • Glutathione transferases from human liver.

    M Warholm;C Guthenberg;C von Bahr;B Mannervik

  • [60] Glutathione peroxidase

    Bengt Mannervik

  • Molecular and catalytic properties of glutathione transferase mu from human liver: an enzyme efficiently conjugating epoxides.

    Margareta Warholm;Claes Guthenberg;Bengt Mannervik

Frequent Co-Authors

Curt R. Enzell
Curt R. Enzell Royal Institute of Technology
Synnøve Liaaen-Jensen
Synnøve Liaaen-Jensen Norwegian University of Science and Technology
Per Jemth
Per Jemth Uppsala University
Gerard J. Kleywegt
Gerard J. Kleywegt European Bioinformatics Institute
Philip G. Board
Philip G. Board Australian National University
Ulf Hellman
Ulf Hellman Ludwig Cancer Research
Joseph W. DePierre
Joseph W. DePierre Stockholm University
Albrecht Seidel
Albrecht Seidel Johannes Gutenberg University of Mainz
Alexander D. Cameron
Alexander D. Cameron University of Warwick
Tamas Bartfai
Tamas Bartfai Stockholm University

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