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Chemistry

D-Index
56
Citations
8887
World Ranking
11885
National Ranking
873

Overview

Albrecht Seidel is affiliated with Johannes Gutenberg University of Mainz in Germany. Their research primarily focuses on environmental science alongside biochemistry, genetics, and molecular biology. The scientist's work addresses various topics including the impact of toxic organic pollutants, risks and effects associated with endocrine disrupting chemicals, and carcinogens and genotoxicity assessment. Additional areas of study include glutathione transferases and polymorphisms, genomics related to phytochemicals and oxidative stress, pharmacogenetics and drug metabolism, as well as analytical chemistry and chromatography.

Significant papers authored by Seidel encompass a range of subjects related to toxicology and molecular interactions. These include:

  • Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells (2020, International Journal of Molecular Sciences)
  • Mixture effects of food-relevant polycyclic aromatic hydrocarbons on the activation of nuclear receptors and gene expression, benzo[a]pyrene metabolite profile and DNA damage in HepaRG cells (2020, Food and Chemical Toxicology)
  • The influence of alkyl substitution on the in vitro metabolism and mutagenicity of benzo[a]pyrene (2022, Chemico-Biological Interactions)
  • A Long-Term Study on the Content of Polycyclic Aromatic Hydrocarbons in Rubber from End-of-Life Tires of Passenger Cars and Trucks (2022, Materials)
  • Urinary Excretion of Mercapturic Acids of the Rodent Carcinogen Methyleugenol after a Single Meal of Basil Pesto: A Controlled Exposure Study in Humans (2023, Chemical Research in Toxicology)

Frequent coauthors in Seidel's publications include Alfonso Lampen, Lisa Goedtke, Albert Braeuning, Stefanie Hessel-Pras, and Ivonne M.C.M. Rietjens. Collaborative work with these researchers spans various projects primarily linked to toxicology and molecular response mechanisms.

The main venues where Seidel's works have been published highlight a consistent presence in journals that specialize in molecular science and toxicology:

  • International Journal of Molecular Sciences (2 publications)
  • Food and Chemical Toxicology
  • Chemico-Biological Interactions
  • Materials
  • Chemical Research in Toxicology

Seidel's areas of study encompass detailed toxicological assessments alongside molecular biology methodologies, frequently investigating the effects of chemical compounds on human liver cells and metabolic pathways. The research integrates toxic organic pollutants' impact with a focus on carcinogen metabolism and mutagenicity, supporting the understanding of chemical interactions at a cellular level and their broader implications in health risk assessments.

Best Publications

  • Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons.

    Kathrin Sundberg;Anne Sofie Johansson;Gun Stenberg;Mikael Widersten

  • Biomonitoring of polycyclic aromatic hydrocarbons in human urine.

    Jürgen Jacob;Albrecht Seidel

  • Identification of BCRP as transporter of benzo[ a ]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists

    Bettina Ebert;Albrecht Seidel;Alfonso Lampen

  • Cancer initiation by polycyclic aromatic hydrocarbons results from formation of stable DNA adducts rather than apurinic sites.

    Victor J. Melendez-Colon;Andreas Luch;Albrecht Seidel;William M. Baird

  • Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol.

    Dongtao Li;Albrecht Seidel;Michael Pritchard;C. Wolf

  • Carbonyl reductase provides the enzymatic basis of quinone detoxication in man

    Bendicht Wermuth;Karl L. Platts;Albrecht Seidel;Franz Oesch

  • Stereoselective activation of dibenzo[a,l]pyrene to (-)-anti (11R,12S,13S,14R)- and (+)-syn(11S,12R,13S,14R)-11,12-diol-13,14-epoxides which bind extensively to deoxyadenosine residues of DNA in the human mammary carcinoma cell line MCF-7.

    Sherry L. Ralston;Albrecht Seidel;Andreas Luch;Karl L. Platt

  • Biomonitoring of polycyclic aromatic compounds in the urine of mining workers occupationally exposed to diesel exhaust

    Albrecht Seidel;Dirk Dahmann;Horst Krekeler;Juergen Jacob

  • Unrepaired fjord region polycyclic aromatic hydrocarbon-DNA adducts in ras codon 61 mutational hot spots.

    Tonko Buterin;Martin T. Hess;Natalia Luneva;Nicholas E. Geacintov

  • Phytochemicals Induce Breast Cancer Resistance Protein in Caco-2 Cells and Enhance the Transport of Benzo[a]pyrene-3-sulfate

    Bettina Ebert;Albrecht Seidel;Alfonso Lampen

  • Agonistic and antagonistic effects of phthalates and their urinary metabolites on the steroid hormone receptors ERα, ERβ, and AR.

    Anika Engel;Thorsten Buhrke;Francine Imber;Sönke Jessel

  • Glutathione conjugation of bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferases M1-1 and P1-1.

    Kathrin Sundberg;Mikael Widersten;Albrecht Seidel;Bengt Mannervik

  • Conversion of the common food constituent 5-hydroxymethylfurfural into a mutagenic and carcinogenic sulfuric acid ester in the mouse in vivo.

    Bernhard H Monien;Heinz Frank;Albrecht Seidel;Hansruedi Glatt

  • Mainstream smoke of the waterpipe: does this environmental matrix reveal as significant source of toxic compounds?

    Jens Schubert;Jürgen Hahn;Gerhard Dettbarn;Albrecht Seidel

  • Fjord- and Bay-Region Diol-Epoxides Investigated for Stability, SOS Induction in Escherichia coli, and Mutagenicity in Salmonella typhimurium and Mammalian Cells

    Hansruedi Glatt;Andrea Piée;Karin Pauly;Thomas Steinbrecher

  • Synthesis and mutagenicity of the diastereomeric fjord-region 11,12-dihydrodiol 13,14-epoxides of dibenzo[a,l]pyrene.

    Andreas Luch;Hansruedi Glatt;Karl L. Platt;Franz Oesch

  • Formation of estrogenic metabolites of benzo[a]pyrene and chrysene by cytochrome P450 activity and their combined and supra-maximal estrogenic activity.

    Marola M.H. van Lipzig;Nico P.E. Vermeulen;Renato Gusinu;Juliette Legler

  • Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR.

    Claudia Luckert;Anke Ehlers;Thorsten Buhrke;Albrecht Seidel

  • CARCINOGENESIS: Glutathione S-transferase A1–1-catalysed conjugation of bay and fjord region diol epoxides of polycyclic aromatic hydrocarbons with glutathione

    Bengt Jernström;Mario Funk;Heinrich Frank;Bengt Mannervik

  • Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism

    Laura E. Wohak;Annette M. Krais;Jill E. Kucab;Julia Stertmann

  • Interaction between Metabolism and Transport of Benzo[a]pyrene and Its Metabolites in Enterocytes

    Roland Buesen;Melissa Mock;Albrecht Seidel;Jürgen Jacob

Frequent Co-Authors

Hansruedi Glatt
Hansruedi Glatt Federal Institute for Risk Assessment
Franz Oesch
Franz Oesch Johannes Gutenberg University of Mainz
David H. Phillips
David H. Phillips King's College London
Bengt Mannervik
Bengt Mannervik Stockholm University
Thomas Brüning
Thomas Brüning Ruhr University Bochum
Volker M. Arlt
Volker M. Arlt King's College London
Michael Wilhelm
Michael Wilhelm Ruhr University Bochum
Robert Landsiedel
Robert Landsiedel BASF (United States)
John J. Stegeman
John J. Stegeman Woods Hole Oceanographic Institution
Frank J. Gonzalez
Frank J. Gonzalez National Institutes of Health

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