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D-Index & Metrics

Chemistry

D-Index
93
Citations
30991
World Ranking
1793
National Ranking
665

Overview

Donald M. Jerina was affiliated with the National Institutes of Health in the United States. Their research contributions spanned several key areas within biochemistry, genetics, and molecular biology, with a focus also on agricultural and biological sciences.

The scientist's published work encompassed topics such as:

  • Light effects on plants
  • DNA repair mechanisms
  • DNA and nucleic acid chemistry

Jerina's subfields of study included molecular biology and plant science, reflecting the interdisciplinary nature of their research.

One documented publication by Jerina is entitled Inhibition of Werner Syndrome Helicase Activity by Benzo[ c ]phenanthrene Diol Epoxide dA Adducts in DNA Is Both Strand-and Stereoisomer-dependent, published in 2021 through UNC Libraries.

Their frequent co-authors comprised researchers from diverse backgrounds, including:

  • Henry C. Driscoll
  • Steven W. Matson
  • Jane M. Sayer
  • Heiko Kroth
  • Robert M. Brosh

Jerina contributed to publications primarily disseminated via UNC Libraries. Their research engaged with complex molecular and biochemical processes, particularly in relation to DNA structure and function, and the interaction of chemical agents with nucleic acids.

Throughout their career, Jerina's work bridged basic science and applied agricultural biology, indicating an interest in understanding biological mechanisms at both molecular and organismal levels, especially within plant systems and DNA repair pathways.

Best Publications

  • Arene oxides: a new aspect of drug metabolism.

    D. M. Jerina;J. W. Daly

  • Arene oxides and the NIH shift: the metabolism, toxicity and carcinogenicity of aromatic compounds.

    J. W. Daly;D. M. Jerina;B. Witkop

  • Hydroxylation-Induced Migration: The NIH Shift Recent experiments reveal an unexpected and general result of enzymatic hydroxylation of aromatic compounds

    Gordon Guroff;Jean Renson;Sidney Udenfriend;John W. Daly

  • 1,2-naphthalene oxide as an intermediate in the microsomal hydroxylation of naphthalene.

    Donald M. Jerina;John W. Daly;Bernhard Witkop;P. Zaltzman-Nirenberg

  • A radiometric assay for hepatic epoxide hydrase activity with [7-3H] styrene oxide☆

    F. Oesch;D.M. Jerina;J. Daly

  • Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene

    M K Buening;P G Wislocki;W Levin;H Yagi

  • Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes.

    A W Wood;W Levin;A Y Lu;H Yagi

  • Hepatic epoxide hydrase. Structure-activity relationships for substrates and inhibitors.

    F. Oesch;N. Kaubisch;D. M. Jerina;J. W. Daly

  • Binding of benzo[a]pyrene 7,8-diol-9,10-epoxides to DNA, RNA, and protein of mouse skin occurs with high stereoselectivity

    Masato Koreeda;Patrick D. Moore;Peter G. Wislocki;Wayne Levin

  • Inhibition of the Mutagenicity of Bay-Region Diol Epoxides of Polycyclic Aromatic Hydrocarbons by Naturally Occurring Plant Phenols: Exceptional Activity of Ellagic Acid

    Alexander W. Wood;Mou-Tuan Huang;Richard L. Chang;Harold L. Newmark

  • Oxidation of the carcinogens benzo[a]pyrene and benzo[a]anthracene to dihydrodiols by a bacterium

    DT Gibson;V Mahadevan;DM Jerina;H Yogi

  • Tumorigenicity studies with diol-epoxides of benzo(a)pyrene which indicate that (+/-)-trans-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene is an ultimate carcinogen in newborn mice.

    Jaime Kapitulnik;Peter G. Wislocki;Wayne Levin;Haruhiko Yagi

  • Initial reactions in the oxidation of naphthalene by Pseudomonas putida

    A. M. Jeffrey;H. J. C. Yeh;D. M. Jerina;T. R. Patel

  • Metabolism of benzo[a]pyrene. VI. Stereoselective metabolism of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol to diol epoxides.

    D.R. Thakker;H. Yagi;H. Akagi;M. Koreeda

  • Role of the arene oxide-oxepin system in the metabolism of aromatic substrates: I. In vitro conversion of benzene oxide to a premercapturic acid and a dihydrodiol

    D. Jerina;J. Daly;B. Witkop;P. Zaltzman-Nirenberg

  • The role of arene oxide-oxepin systems in the metabolism of aromatic substrates. III. Formation of 1,2-naphthalene oxide from naphthalene by liver microsomes

    Donald M. Jerina;John W. Daly;Bernhard Witkop;Perola Zaltzman-Nirenberg

  • BENZO(A)PYRENE 7,8-DIHYDRODIOL IS MORE CARCINOGENIC THAN BENZO(A)PYRENE IN NEWBORN MICE

    J. Kapitulnik;W. Levin;A. H. Conney;H. Yagi

  • Effects of Inducers and Epoxide Hydrase on the Metabolism of Benzo[a]pyrene by Liver Microsomes and a Reconstituted System: Analysis by High Pressure Liquid Chromatography

    Gerald Holder;Haruhiko Yagi;Patrick Dansette;Donald M. Jerina

  • DIHYDRODIOLS FROM ANTHRACENE AND PHENANTHRENE

    D. M. Jerina;H. Selander;H. Yagi;M. C. Wells

  • Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by phenolic plant flavonoids

    Mou-Tuan Huang;Alexander W. Wood;Harold L. Newmark;Jane.M. Sayer

Frequent Co-Authors

Haruhiko Yagi
Haruhiko Yagi National Institutes of Health
Jane M. Sayer
Jane M. Sayer National Institutes of Health
Wayne Levin
Wayne Levin Roche (Switzerland)
Allan H. Conney
Allan H. Conney Rutgers, The State University of New Jersey
Dhiren R. Thakker
Dhiren R. Thakker University of North Carolina at Chapel Hill
Derek R. Boyd
Derek R. Boyd Queen's University Belfast
John W. Daly
John W. Daly National Institutes of Health
Anthony Dipple
Anthony Dipple National Institutes of Health
Patrick M. Dansette
Patrick M. Dansette Université Paris Cité
Paul E. Thomas
Paul E. Thomas Rutgers, The State University of New Jersey

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