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Patrick M. Dansette

Patrick M. Dansette

D-Index & Metrics

Chemistry

D-Index
60
Citations
9105
World Ranking
9961
National Ranking
363

Overview

Patrick M. Dansette is affiliated with Université Paris Cité in France and specializes primarily in the field of Biochemistry, Genetics and Molecular Biology. Their research spans multiple subfields including Molecular Biology, Organic Chemistry, Physiology, Biochemistry, and Pharmacology.

Their scientific contributions focus on several main topics:

  • Ferrocene Chemistry and Applications
  • Metal complexes synthesis and properties
  • Synthesis and Biological Evaluation
  • Lysosomal Storage Disorders Research
  • Cellular transport and secretion
  • Calcium signaling and nucleotide metabolism
  • Spectroscopy and Quantum Chemical Studies

Recent publications by Patrick M. Dansette demonstrate a range of interdisciplinary interests. Notable papers include:

  • Diversity-oriented synthesis and bioactivity evaluation of N-substituted ferrocifen compounds as novel antiproliferative agents against TNBC cancer cells, 2022, European Journal of Medicinal Chemistry
  • Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin, 2020, Journal of Medicinal Chemistry
  • High throughput wide field second harmonic imaging of giant unilamellar vesicles, 2023, Biointerphases
  • Monooxygenase- and Dioxygenase-Catalyzed Oxidative Dearomatization of Thiophenes by Sulfoxidation, cis-Dihydroxylation and Epoxidation, 2022, International Journal of Molecular Sciences
  • Comparison of Various Aryl-Dithiolethiones and Aryl-Dithiolones As Hydrogen Sulfide Donors in the Presence of Rat Liver Microsomes, 2020, Drug Metabolism and Disposition

The scientist has frequently published in journals such as the International Journal of Molecular Sciences, European Journal of Medicinal Chemistry, Journal of Medicinal Chemistry, Biointerphases, and Drug Metabolism and Disposition.

Collaborations are a significant component of their research output, with repeated co-authorship alongside colleagues including:

  • Nicolas Pietrancosta
  • Daniel Mansuy
  • Jean-Luc Boucher
  • Yong Wang
  • Pascal Pigeon

Patrick M. Dansette's work addresses critical areas relating to molecular interactions, synthesis of biologically active compounds, and cellular processes. Their research contributions span experimental approaches intersecting organic chemistry and molecular biology, with implications for understanding disease mechanisms and developing therapeutic agents.

Best Publications

  • Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug.

    Ph. Beaune;P. M. Dansette;D. Mansuy;L. Kiffel

  • Effects of Inducers and Epoxide Hydrase on the Metabolism of Benzo[a]pyrene by Liver Microsomes and a Reconstituted System: Analysis by High Pressure Liquid Chromatography

    Gerald Holder;Haruhiko Yagi;Patrick Dansette;Donald M. Jerina

  • Structure of a Substrate Complex of Mammalian Cytochrome P450 2C5 at 2.3 Å Resolution: Evidence for Multiple Substrate Binding Modes†,‡

    Michael R. Wester;Eric F. Johnson;Cristina Marques-Soares;Patrick M. Dansette

  • Cytochrome P450 enzymes mechanism based inhibitors: Common sub-structures and reactivity

    Elena Fontana;Patrick Dansette;Sonia Poli

  • Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 A resolution: evidence for an induced fit model of substrate binding.

    M.R Wester;E.F Johnson;C Marques-Soares;S Dijols

  • Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: Inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid

    M P López-Garcia;P M Dansette;D Mansuy

  • Mutagenicity and Cytotoxicity of Benzo(a)pyrene Arene Oxides, Phenols, Quinones, and Dihydrodiols in Bacterial and Mammalian Cells

    Wislocki Pg;Wood Aw;Chang Rl;Levin W

  • Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid.

    Guillaume A. Schoch;Jason K. Yano;Stefaan Sansen;Patrick M. Dansette

  • Ferrocenyl Quinone Methides as Strong Antiproliferative Agents: Formation by Metabolic and Chemical Oxidation of Ferrocenyl Phenols

    Didier Hamels;Patrick M. Dansette;Elizabeth A. Hillard;Siden Top

  • Facile synthesis of arene oxides at the K regions of polycyclic hydrocarbons

    Patrick Dansette;Donald M. Jerina

  • Carcinogenicity of benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides on mouse skin.

    W Levin;A W Wood;H Yagi;P M Dansette

  • Specificity of in vitro covalent binding of tienilic acid metabolites to human liver microsomes in relationship to the type of hepatotoxicity: comparison with two directly hepatotoxic drugs.

    Sylvaine Lecoeur;Eric Bonierbale;Dominique Challine;Jean-Charles Gautier

  • The substrate binding site of human liver cytochrome P450 2C9: an approach using designed tienilic acid derivatives and molecular modeling.

    Annah Mancy;Pierre Broto;Sylvie Dijols;Patrick M. Dansette

  • Hepatotoxicity of germander in mice.

    Jacqueline Loeper;Veronique Descatoire;Philippe Letteron;Claude Moulis

  • IN VITRO METABOLISM OF XENOBIOTICS IN SOME MARINE ANIMALS

    John R. Bend;Margaret O. James;Patrick M. Dansette

  • Continuous fluorometric assay of epoxide hydrase activity

    Patrick M. Dansette;Garrett C. DuBois;Donald M. Jerina

  • Cytochromes P450 Catalyze Both Steps of the Major Pathway of Clopidogrel Bioactivation, whereas Paraoxonase Catalyzes the Formation of a Minor Thiol Metabolite Isomer

    Patrick M. Dansette;Julien Rosi;Gildas Bertho;Daniel Mansuy

  • Chemical and Biological Oxidation of Thiophene: Preparation and Complete Characterization of Thiophene S-Oxide Dimers and Evidence for Thiophene S-Oxide as an Intermediate in Thiophene Metabolism in Vivo and in Vitro

    Alexander Treiber;Patrick M. Dansette;Hamid El Amri;† Jean-Pierre Girault

  • Metabolic oxidative cleavage of thioesters: evidence for the formation of sulfenic acid intermediates in the bioactivation of the antithrombotic prodrugs ticlopidine and clopidogrel.

    Patrick M. Dansette;Julie Libraire;Gildas Bertho;Daniel Mansuy

  • Substrate selectivity of human cytochrome P450 2C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism-based inactivation by tienilic acid

    Armelle Melet;Nadine Assrir;Pascale Jean;Maria Pilar Lopez-Garcia

  • Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. Oxidative activation of tienilic acid by cytochromes P-450 2C9 and 2C10.

    M. Pilar Lopez Garcia;Patrick M. Dansette;Philippe Valadon;Claudine Amar

  • Thiophene sulfoxides as reactive metabolites: formation upon microsomal oxidation of a 3-aroylthiophene and fate in the presence of nucleophiles in vitro and in vivo.

    Philippe Valadon;Patrick M. Dansette;Jean-Pierre Girault;Claudine Amar

Frequent Co-Authors

Donald M. Jerina
Donald M. Jerina National Institutes of Health
Haruhiko Yagi
Haruhiko Yagi National Institutes of Health
Gérard Jaouen
Gérard Jaouen Chimie ParisTech
Anne Vessières
Anne Vessières Université Paris Cité
Philippe Beaune
Philippe Beaune Université Paris Cité
Allan H. Conney
Allan H. Conney Rutgers, The State University of New Jersey
Wayne Levin
Wayne Levin Roche (Switzerland)
Eric F. Johnson
Eric F. Johnson AbbVie (United States)
Darryl C. Zeldin
Darryl C. Zeldin National Institutes of Health

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