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Biology and Biochemistry
France
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
94
Citations
27235
World Ranking
2044
National Ranking
40

Medicine

D-Index
95
Citations
27817
World Ranking
10186
National Ranking
315

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in France Leader Award

Overview

Philippe Beaune is affiliated with Université Paris Cité in France. Their research spans several interconnected fields including Biochemistry, Genetics and Molecular Biology, Neuroscience, and Medicine. Within these domains, their work further specializes in Molecular Biology, Biological Psychiatry, Infectious Diseases, Neurology, and Computational Theory and Mathematics.

The scientist's main research topics focus on Pharmacological Receptor Mechanisms and Effects, Tryptophan and brain disorders, COVID-19 Clinical Research Studies, Long-Term Effects of COVID-19, Computational Drug Discovery Methods, and Synthesis and biological activity.

Beaune has contributed to multiple scientific publications, with recent papers addressing topics related to drug repurposing and COVID-19 treatment strategies. These publications include:

  • Prevention of COVID-19 by drug repurposing: rationale from drugs prescribed for mental disorders (2020) in Drug Discovery Today
  • Antihistamine and cationic amphiphilic drugs, old molecules as new tools against the COVID-19? (2021) in Medical Hypotheses
  • Chemoinformatic Analysis of Psychotropic and Antihistaminic Drugs in the Light of Experimental Anti-SARS-CoV-2 Activities (2021) in Advances and Applications in Bioinformatics and Chemistry

Their work frequently appears in the following publication venues:

  • Drug Discovery Today
  • Medical Hypotheses
  • Advances and Applications in Bioinformatics and Chemistry

Collaborations form a significant part of Beaune's research activity. Frequent co-authors include:

  • Bruno O. Villoutreix
  • Marion Leboyer
  • Ryad Tamouza
  • Rajagopal Krishnamoorthy
  • Clara Gitahy Falcão Faria

Best Publications

  • Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

    F P Guengerich;M V Martin;P H Beaune;P Kremers

  • Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

    Raimund Peter;Ronald Boecker;Philippe H. Beaune;Masahiko Iwasaki

  • Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues

    I. De Waziers;P. H. Cugnenc;Chung Yang;J. P. Leroux

  • Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture.

    Ziad Abdel-Razzak;P. Loyer;A. Fautrel;J.-C. Gautier

  • Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity

    Laurent Bodin;Céline Verstuyft;David-Alexandre Tregouet;Annie Robert

  • Human cytochromes P450

    Julia A Hasler;Ronald Estabrook;Michael Murray;Irina Pikuleva

  • Detection of free‐circulating tumor‐associated DNA in plasma of colorectal cancer patients and its association with prognosis

    Thierry Lecomte;Anne Berger;Franck Zinzindohoué;Stéphanie Micard

  • The increase in urinary excretion of 6 beta-hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction.

    C Ged;JM Rouillon;L Pichard;J Combalbert

  • Impact of cytochrome p450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients.

    Eric Thervet;Dany Anglicheau;Barry King;Marie-Hélène Schlageter

  • Association of the Multidrug Resistance-1 Gene Single-Nucleotide Polymorphisms with the Tacrolimus Dose Requirements in Renal Transplant Recipients

    Dany Anglicheau;Céline Verstuyft;Pierre Laurent-Puig;Laurent Becquemont

  • Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues.

    Ivan Bièche;Cèline Narjoz;Tarik Asselah;Sophie Vacher

  • Analgesic effect of acetaminophen in humans: First evidence of a central serotonergic mechanism

    Gisèle Pickering;Marie-Anne Loriot;Frédéric Libert;Alain Eschalier

  • Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes.

    Christelle Iribarne;François Berthou;Susan Baird;Yvonne Dréano

  • Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens.

    T. Shimada;Chul-Ho Yun;H. Yamazaki;J.-C. Gautier

  • Human CYP2B6: expression, inducibility and catalytic activities.

    L Gervot;B Rochat;J C Gautier;F Bohnenstengel

  • Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy

    Thierry Lecomte;Jean-Marc Ferraz;Franck Zinzindohoué;Marie-Anne Loriot

  • Glutathione S-Transferase P1 Polymorphism (Ile105Val) Predicts Cumulative Neuropathy in Patients Receiving Oxaliplatin-Based Chemotherapy

    Thierry Lecomte;Bruno Landi;Philippe Beaune;Pierre Laurent-Puig

  • Purification and characterization of six cytochrome P-450 isozymes from human liver microsomes.

    Wang Pp;Beaune P;Kaminsky Ls;Dannan Ga

  • Identification of the cytochrome P450 IIIA family as the enzymes involved in the N-demethylation of tamoxifen in human liver microsomes.

    Françoise Jacolot;Isabelle Simon;Yvonne Dreano;Philippe Beaune

  • Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis.

    M Bourdi;D Larrey;J Nataf;J Bernuau

Frequent Co-Authors

Pierre Laurent-Puig
Pierre Laurent-Puig Université Paris Cité
Christophe Legendre
Christophe Legendre Necker-Enfants Malades Hospital
André Guillouzo
André Guillouzo University of Rennes
Christian Funck-Brentano
Christian Funck-Brentano Université Paris Cité
Patrick M. Dansette
Patrick M. Dansette Université Paris Cité
F. Peter Guengerich
F. Peter Guengerich Vanderbilt University
Robert Barouki
Robert Barouki Université Paris Cité
David-Alexandre Trégouët
David-Alexandre Trégouët University of Bordeaux

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