What is he best known for?
The fields of study he is best known for:
- Enzyme
- Gene
- Organic chemistry
Hiroshi Yamazaki mostly deals with Biochemistry, Cytochrome P450, Microsome, Enzyme and CYP3A4.
His work in Biochemistry is not limited to one particular discipline; it also encompasses Stereochemistry.
His biological study spans a wide range of topics, including Metabolite, Cytochrome and Drug metabolism.
His Microsome research is multidisciplinary, incorporating elements of Cytochrome P-450 CYP3A, Isozyme, Internal medicine and Endocrinology.
As part of the same scientific family, Hiroshi Yamazaki usually focuses on Enzyme, concentrating on Peptide sequence and intersecting with Molecular biology.
His CYP3A4 study frequently links to other fields, such as Pharmacology.
His most cited work include:
- Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. (2495 citations)
- Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1 (720 citations)
- Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes (337 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of study are Cytochrome P450, Biochemistry, Pharmacology, Microsome and Enzyme.
His work carried out in the field of Cytochrome P450 brings together such families of science as Molecular biology, Drug metabolism and Hydroxylation.
His Molecular biology research is multidisciplinary, relying on both Complementary DNA and Genetics.
His Biochemistry study frequently involves adjacent topics like Stereochemistry.
His research integrates issues of Metabolite and In vivo in his study of Pharmacology.
His Microsome study combines topics from a wide range of disciplines, such as Endocrinology, Monooxygenase, Cytochrome P-450 CYP3A, Internal medicine and Isozyme.
He most often published in these fields:
- Cytochrome P450 (19.98%)
- Biochemistry (18.64%)
- Pharmacology (18.26%)
What were the highlights of his more recent work (between 2016-2021)?
- Pharmacology (18.26%)
- Pharmacokinetics (8.70%)
- Enzyme (13.10%)
In recent papers he was focusing on the following fields of study:
Hiroshi Yamazaki mainly investigates Pharmacology, Pharmacokinetics, Enzyme, Drug metabolism and Cytochrome P450.
The concepts of his Pharmacology study are interwoven with issues in Metabolite, Thalidomide, Toxicity and In vivo.
His Pharmacokinetics research includes elements of Oral administration, Chromatography and Glucuronide.
His research in Enzyme tackles topics such as Molecular biology which are related to areas like Amino acid.
His Drug metabolism study also includes
- Genetics, which have a strong connection to Monooxygenase,
- CYP3A4 that connect with fields like Hydroxylation.
His study with Cytochrome P450 involves better knowledge in Biochemistry.
Between 2016 and 2021, his most popular works were:
- The Dihydroxy Metabolite of the Teratogen Thalidomide Causes Oxidative DNA Damage (22 citations)
- Rigid-to-Flexible Conformational Transformation: An Efficient Route to Ring-Opening of a Tröger’s Base-Containing Ladder Polymer (19 citations)
- Plasma and Hepatic Concentrations of Chemicals after Virtual Oral Administrations Extrapolated Using Rat Plasma Data and Simple Physiologically Based Pharmacokinetic Models. (16 citations)
In his most recent research, the most cited papers focused on:
- Enzyme
- Gene
- Internal medicine
Hiroshi Yamazaki focuses on Pharmacology, Pharmacokinetics, Drug metabolism, Cytochrome P450 and Marmoset.
His studies in Pharmacology integrate themes in fields like In vitro, Thalidomide, Toxicity and In vivo.
While the research belongs to areas of In vivo, Hiroshi Yamazaki spends his time largely on the problem of Microsome, intersecting his research to questions surrounding Hydroxylation.
His Pharmacokinetics research incorporates elements of Oral administration, Metabolite, CYP2C19 and Warfarin.
His Drug metabolism research includes themes of CYP3A4, Nonsynonymous substitution and Gene, Gene isoform.
His Cytochrome P450 study is concerned with the larger field of Biochemistry.
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