D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 91 Citations 25,866 462 World Ranking 7404 National Ranking 291

Overview

What is she best known for?

The fields of study she is best known for:

  • Internal medicine
  • Gene
  • Enzyme

Rachel F. Tyndale mainly focuses on Nicotine, Pharmacology, CYP2A6, Cotinine and Smoking cessation. Nicotine is a subfield of Internal medicine that Rachel F. Tyndale studies. Her Pharmacology study incorporates themes from CYP2B6, Microsome, Addiction and Cytochrome P450.

The study incorporates disciplines such as Oral administration, Pharmacogenetics, Genotype and Genetic variation in addition to CYP2A6. Her studies deal with areas such as Metabolite, Urine and Carcinogen as well as Cotinine. The Smoking cessation study combines topics in areas such as Anesthesia, Placebo and Single-nucleotide polymorphism.

Her most cited work include:

  • Guidelines on nicotine dose selection for in vivo research (627 citations)
  • Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. (450 citations)
  • A Major Role for CYP2A6 in Nicotine C-Oxidation by Human Liver Microsomes (377 citations)

What are the main themes of her work throughout her whole career to date?

Rachel F. Tyndale mainly investigates Nicotine, Pharmacology, CYP2A6, Internal medicine and Smoking cessation. Cotinine is the focus of her Nicotine research. Her studies examine the connections between Pharmacology and genetics, as well as such issues in Cytochrome P450, with regards to Neurotoxicity.

Her CYP2A6 research incorporates themes from Nicotine metabolism, Genetic variation, Allele and Genotype. Her study looks at the relationship between Internal medicine and topics such as Endocrinology, which overlap with Endocannabinoid system and Alkaloid. Her Smoking cessation research incorporates elements of Randomized controlled trial and Abstinence.

She most often published in these fields:

  • Nicotine (72.14%)
  • Pharmacology (45.57%)
  • CYP2A6 (37.45%)

What were the highlights of her more recent work (between 2018-2021)?

  • Nicotine (72.14%)
  • Internal medicine (39.67%)
  • Smoking cessation (33.95%)

In recent papers she was focusing on the following fields of study:

Her scientific interests lie mostly in Nicotine, Internal medicine, Smoking cessation, Endocrinology and Cotinine. Her research in Nicotine intersects with topics in Metabolite, Craving, CYP2A6 and Physiology. Her research integrates issues of Pharmacokinetics, Pharmacology, Glucuronidation, Urine and Biomarker in her study of Metabolite.

Rachel F. Tyndale interconnects Pharmacogenetics, Genome-wide association study, Allele and Genetic association in the investigation of issues within CYP2A6. Rachel F. Tyndale has included themes like Nicotine patch and Randomized controlled trial in her Smoking cessation study. Rachel F. Tyndale combines subjects such as Gastroenterology, Buprenorphine, Opioid and Methadone with her study of Cotinine.

Between 2018 and 2021, her most popular works were:

  • PharmVar GeneFocus: CYP2D6. (40 citations)
  • The Late Positive Potentials Evoked by Cigarette-Related and Emotional Images Show no Gender Differences in Smokers. (37 citations)
  • Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-Containing Antiretroviral Therapy. (36 citations)

In her most recent research, the most cited papers focused on:

  • Internal medicine
  • Gene
  • Enzyme

Nicotine, Internal medicine, Smoking cessation, Endocrinology and CYP2A6 are her primary areas of study. Rachel F. Tyndale specializes in Nicotine, namely Cotinine. Her research in the fields of Nucleus accumbens overlaps with other disciplines such as Efavirenz.

Her study in Smoking cessation is interdisciplinary in nature, drawing from both Young adult, Abstinence and Physiology. Her studies in Endocrinology integrate themes in fields like Tropomyosin receptor kinase B and Endocannabinoid system. Her CYP2A6 research is multidisciplinary, relying on both Metabolite, Pharmacogenetics, Genome-wide association study and Allele.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Guidelines on nicotine dose selection for in vivo research

Shannon G. Matta;David J. Balfour;Neal L. Benowitz;R. Thomas Boyd.
Psychopharmacology (2007)

825 Citations

Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.

T Aoyama;S Yamano;D J Waxman;D P Lapenson.
Journal of Biological Chemistry (1989)

694 Citations

Nicotine metabolism defect reduces smoking

Michael L. Pianezza;Edward M. Sellers;Rachel F. Tyndale.
Nature (1998)

573 Citations

A Major Role for CYP2A6 in Nicotine C-Oxidation by Human Liver Microsomes

E S Messina;R F Tyndale;E M Sellers.
Journal of Pharmacology and Experimental Therapeutics (1997)

552 Citations

Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity.

Delia Dempsey;Delia Dempsey;Delia Dempsey;Piotr Tutka;Piotr Tutka;Piotr Tutka;Peyton Jacob;Peyton Jacob;Peyton Jacob;Faith Allen;Faith Allen;Faith Allen.
Clinical Pharmacology & Therapeutics (2004)

430 Citations

Incorporation of Pharmacogenomics into Routine Clinical Practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process

Kelly E. Caudle;Teri E. Klein;James M. Hoffman;Daniel J. Muller.
Current Drug Metabolism (2014)

364 Citations

Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians.

Kerri A Schoedel;Ewa B Hoffmann;Yushu Rao;Edward M Sellers.
Pharmacogenetics (2004)

361 Citations

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

James D McKay;Rayjean J Hung;Younghun Han;Xuchen Zong.
Nature Genetics (2017)

356 Citations

Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence.

Viba Malaiyandi;Edward M. Sellers;Rachel F. Tyndale.
Clinical Pharmacology & Therapeutics (2005)

342 Citations

Duplications and Defects in the CYP2A6 Gene: Identification, Genotyping, and In Vivo Effects on Smoking

Yushu Rao;Ewa Hoffmann;Mohammad Zia;Laurent Bodin.
Molecular Pharmacology (2000)

334 Citations

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