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Rachel F. Tyndale

Rachel F. Tyndale

D-Index & Metrics

Medicine

D-Index
96
Citations
31437
World Ranking
9739
National Ranking
390

Overview

Rachel F. Tyndale is affiliated with the University of Toronto in Canada. Their research spans various disciplines with a primary focus on medicine, particularly within physiology, pharmacology, molecular biology, public health, environmental and occupational health, and cellular and molecular neuroscience.

Their work addresses several important scientific topics including:

  • Smoking Behavior and Cessation
  • Nicotinic Acetylcholine Receptors Study
  • Cannabis and Cannabinoid Research
  • Pharmacogenetics and Drug Metabolism
  • Diet and metabolism studies
  • Alcohol Consumption and Health Effects
  • Behavioral Health and Interventions

They have contributed to numerous scholarly articles published across notable venues. Frequent publication venues include:

  • Biological Psychiatry
  • Nicotine & Tobacco Research
  • Clinical Pharmacology & Therapeutics
  • Neuropsychopharmacology
  • Drug and Alcohol Dependence

Recent papers authored or co-authored by Rachel F. Tyndale cover various specialized topics:

  • PharmVar GeneFocus: CYP2B6, 2021, Clinical Pharmacology & Therapeutics
  • Sex difference in dopamine D1-D2 receptor complex expression and signaling affects depression- and anxiety-like behaviors, 2020, Biology of Sex Differences
  • Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent, 2020, Molecular Psychiatry
  • Contribution of Biotransformations Carried Out by the Microbiota, Drug-Metabolizing Enzymes, and Transport Proteins to the Biological Activities of Phytochemicals Found in the Diet, 2021, Advances in Nutrition
  • Lower brain fatty acid amide hydrolase in treatment-seeking patients with alcohol use disorder: a positron emission tomography study with [C-11]CURB, 2020, Neuropsychopharmacology

Collaboration is a key aspect of their research, with frequent co-authors including:

  • Meghan J. Chenoweth
  • Isabelle Boileau
  • Caryn Lerman
  • Jo Knight
  • Sharon Miksys

Rachel F. Tyndale's extensive body of work reflects a broad engagement with topics relevant to pharmacology, neuroscience, and public health, emphasizing the interplay of genetics, drug metabolism, and behavioral aspects in health outcomes.

Best Publications

  • Guidelines on nicotine dose selection for in vivo research

    Shannon G. Matta;David J. Balfour;Neal L. Benowitz;R. Thomas Boyd

  • Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

    James D McKay;Rayjean J Hung;Younghun Han;Xuchen Zong

  • Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.

    T Aoyama;S Yamano;D J Waxman;D P Lapenson

  • Nicotine metabolism defect reduces smoking

    Michael L. Pianezza;Edward M. Sellers;Rachel F. Tyndale

  • A Major Role for CYP2A6 in Nicotine C-Oxidation by Human Liver Microsomes

    E S Messina;R F Tyndale;E M Sellers

  • Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity.

    Delia Dempsey;Delia Dempsey;Delia Dempsey;Piotr Tutka;Piotr Tutka;Piotr Tutka;Peyton Jacob;Peyton Jacob;Peyton Jacob;Faith Allen;Faith Allen;Faith Allen

  • Incorporation of Pharmacogenomics into Routine Clinical Practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process

    Kelly E. Caudle;Teri E. Klein;James M. Hoffman;Daniel J. Muller

  • Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians.

    Kerri A Schoedel;Ewa B Hoffmann;Yushu Rao;Edward M Sellers

  • Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence.

    Viba Malaiyandi;Edward M. Sellers;Rachel F. Tyndale

  • Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation.

    Caryn Lerman;Rachel Tyndale;Freda Patterson;E. Paul Wileyto

  • Duplications and Defects in the CYP2A6 Gene: Identification, Genotyping, and In Vivo Effects on Smoking

    Yushu Rao;Ewa Hoffmann;Mohammad Zia;Laurent Bodin

  • Nicotine-dependence symptoms are associated with smoking frequency in adolescents

    Jennifer O'Loughlin;Joseph DiFranza;Rachel F Tyndale;Garbis Meshefedjian

  • Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo-controlled trial

    Caryn Lerman;Robert A. Schnoll;Larry W. Hawk;Paul M Cinciripini

  • The pharmacogenetics research network: from SNP discovery to clinical drug response.

    K M Giacomini;C M Brett;R B Altman;N L Benowitz

  • Cytochrome P450 enzymes in the brain: emerging evidence of biological significance.

    Charmaine S. Ferguson;Rachel F. Tyndale

  • Genetics of alcohol and tobacco use in humans

    Rachel F Tyndale

  • Inhibition of cytochromes P450 by antifungal imidazole derivatives.

    Wenjiang Zhang;Yamini Ramamoorthy;Tansel Kilicarslan;Helma Nolte

  • CYP2A6 genotype and the metabolism and disposition kinetics of nicotine

    Neal L. Benowitz;Gary E. Swan;Peyton Jacob;Christina N. Lessov‐Schlaggar

  • The dopamine transporter and cytochrome P450IID1 (debrisoquine 4-hydroxylase) in brain: Resolution and identification of two distinct [3H]GBR-12935 binding proteins

    Hyman B. Niznik;Rachel F. Tyndale;Floyd R. Sallee;Frank J. Gonzalez

  • Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain.

    Sharon Miksys;Caryn Lerman;Peter G. Shields;Deborah C. Mash

Frequent Co-Authors

Neal L. Benowitz
Neal L. Benowitz University of California, San Francisco
Edward M. Sellers
Edward M. Sellers University of Toronto
Caryn Lerman
Caryn Lerman University of Southern California
Tony P. George
Tony P. George Centre for Addiction and Mental Health
Gary E. Swan
Gary E. Swan Stanford University
John A. Cunningham
John A. Cunningham Centre for Addiction and Mental Health
Isabelle Boileau
Isabelle Boileau Centre for Addiction and Mental Health
Larry W. Hawk
Larry W. Hawk University at Buffalo, State University of New York
Jasjit S. Ahluwalia
Jasjit S. Ahluwalia Brown University
Jaakko Kaprio
Jaakko Kaprio University of Helsinki

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