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Tsuyoshi Yokoi

Tsuyoshi Yokoi

D-Index & Metrics

Biology and Biochemistry

D-Index
93
Citations
25571
World Ranking
2145
National Ranking
124

Overview

Tsuyoshi Yokoi is a researcher affiliated with Nagoya University in Japan, with a focus in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields, including Pharmacology, Molecular Biology, Cancer Research, Oncology, and Surgery.

The primary topics Yokoi has investigated include Drug-Induced Hepatotoxicity and Protection, MicroRNA in disease regulation, Pharmacogenetics and Drug Metabolism, Drug Transport and Resistance Mechanisms, Extracellular vesicles in disease, Mechanical Circulatory Support Devices, and Cardiac Structural Anomalies and Repair.

Among Yokoi's recent published papers are the following:

  • Models of Idiosyncratic Drug-Induced Liver Injury, 2020, The Annual Review of Pharmacology and Toxicology
  • Non-P450 Drug-Metabolizing Enzymes: Contribution to Drug Disposition, Toxicity, and Development, 2021, The Annual Review of Pharmacology and Toxicology
  • Expression of the chrXq27.3 miRNA cluster in recurrent ovarian clear cell carcinoma and its impact on cisplatin resistance, 2021, Oncogene
  • An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury, 2020, Archives of Toxicology
  • Macrophage-derived extracellular vesicles regulate concanavalin A-induced hepatitis by suppressing macrophage cytokine production, 2020, Toxicology

Yokoi frequently collaborates with several co-authors, including Shingo Oda, Hiroaki Kajiyama, Toyoaki Murohara, Kosuke Yoshida, and Akira Yokoi. These colleagues have contributed to multiple publications alongside Yokoi.

Yokoi's research is regularly published in a range of venues that include Toxicology, The Annual Review of Pharmacology and Toxicology, The International Journal of Artificial Organs, Drug Metabolism and Pharmacokinetics, and Oncogene.

Best Publications

  • Cytochrome P450-mediated metabolism of estrogens and its regulation in human

    Yuki Tsuchiya;Miki Nakajima;Tsuyoshi Yokoi

  • Near Completely Humanized Liver in Mice Shows Human-Type Metabolic Responses to Drugs

    Chise Tateno;Yasumi Yoshizane;Naomi Saito;Miho Kataoka

  • Role of human cytochrome P4502A6 in C-oxidation of nicotine.

    M. Nakajima;T. Yamamoto;K.-I. Nunoya;T. Yokoi

  • MicroRNA Regulates the Expression of Human Cytochrome P450 1B1

    Yuki Tsuchiya;Miki Nakajima;Shingo Takagi;Takao Taniya

  • Genetic polymorphism in the 5'-flanking region of human CYP1A2 gene: effect on the CYP1A2 inducibility in humans.

    Miki Nakajima;Miki Nakajima;Tsuyoshi Yokoi;Tsuyoshi Yokoi;Mayumi Mizutani;Moritoshi Kinoshita

  • Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats.

    Kiyoshi Takasuna;Takehiro Hagiwara;Masaaki Hirohashi;Michiyuki Kato

  • Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis.

    Takashi Nozawa;Miki Nakajima;Ikumi Tamai;Kumiko Noda

  • Characterization of CYP2A6 involved in 3'-hydroxylation of cotinine in human liver microsomes.

    M. Nakajima;T. Yamamoto;K.-I. Nunoya;T. Yokoi

  • Post-transcriptional Regulation of Human Pregnane X Receptor by Micro-RNA Affects the Expression of Cytochrome P450 3A4

    Shingo Takagi;Miki Nakajima;Takuya Mohri;Tsuyoshi Yokoi

  • Human CYP1B1 Is Regulated by Estradiol via Estrogen Receptor

    Yuki Tsuchiya;Miki Nakajima;Satoru Kyo;Taro Kanaya

  • Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines.

    Akiko Nakamura;Miki Nakajima;Hiroyuki Yamanaka;Ryoichi Fujiwara

  • Comprehensive evaluation of variability in nicotine metabolism and CYP2A6 polymorphic alleles in four ethnic populations

    Miki Nakajima;Miki Nakajima;Miki Nakajima;Tatsuki Fukami;Tatsuki Fukami;Tatsuki Fukami;Hiroyuki Yamanaka;Hiroyuki Yamanaka;Hiroyuki Yamanaka;Eriko Higashi;Eriko Higashi;Eriko Higashi

  • Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli.

    Hiroshi Yamazaki;Mami Nakamura;Tomoko Komatsu;Katsuhiro Ohyama

  • Quantitative analysis of UDP-glucuronosyltransferase (UGT) 1A and UGT2B expression levels in human livers.

    Takeshi Izukawa;Miki Nakajima;Ryoichi Fujiwara;Hiroyuki Yamanaka

  • The emerging role of human esterases.

    Tatsuki Fukami;Tsuyoshi Yokoi

  • Inhibitory effects of amiodarone and its N‐deethylated metabolite on human cytochrome P450 activities: Prediction of in vivo drug interactions

    K. Ohyama;M. Nakajima;M. Suzuki;N. Shimada

  • MicroRNA regulates human vitamin D receptor.

    Takuya Mohri;Miki Nakajima;Shingo Takagi;Sayaka Komagata

  • A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development.

    Shingo Oda;Tatsuki Fukami;Tsuyoshi Yokoi;Miki Nakajima

  • Tissue-specific mRNA Expression Profiles of Human Nuclear Receptor Subfamilies

    Masuhiro Nishimura;Shinsaku Naito;Tsuyoshi Yokoi

  • A significant role of human cytochrome P450 2C8 in amiodarone N-deethylation : an approach to predict the contribution with relative activity factor

    Katsuhiro Ohyama;Miki Nakajima;Sumika Nakamura;Noriaki Shimada

Frequent Co-Authors

Miki Nakajima
Miki Nakajima Kanazawa University
Tetsuya Kamataki
Tetsuya Kamataki Hokkaido University
Koichi Tsuneyama
Koichi Tsuneyama University of Tokushima
Hiroshi Yamazaki
Hiroshi Yamazaki Showa Pharmaceutical University
Toyoaki Murohara
Toyoaki Murohara Nagoya University
Katsutoshi Yoshizato
Katsutoshi Yoshizato Osaka Metropolitan University
Howard L. McLeod
Howard L. McLeod Utah Tech University
Motoya Katsuki
Motoya Katsuki University of Tokyo
Susumu Itoh
Susumu Itoh Showa Pharmaceutical University
Yoshihiko Funae
Yoshihiko Funae Osaka Metropolitan University

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