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Biology and Biochemistry

D-Index
49
Citations
15286
World Ranking
17840
National Ranking
1288

Overview

Susumu Itoh is affiliated with Showa Pharmaceutical University in Japan and has contributed to research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Molecular Biology, Pediatrics, Perinatology and Child Health, Pulmonary and Respiratory Medicine, Cell Biology, and Cancer Research.

The research topics addressed by Susumu Itoh include:

  • Neonatal Health and Biochemistry
  • Heme Oxygenase-1 and Carbon Monoxide
  • Methemoglobinemia and Tumor Lysis Syndrome
  • TGF-β signaling in diseases
  • Epigenetics and DNA Methylation
  • Metabolism, Diabetes, and Cancer
  • Cancer-related gene regulation

Recent scientific papers featuring Susumu Itoh or closely related to their research activity include:

  • "Dissociation of the AhR/ARNT complex by TGF-β/Smad signaling represses CYP1A1 gene expression and inhibits benze[a]pyrene-mediated cytotoxicity," 2020, Journal of Biological Chemistry
  • "Smad7 Enhances TGF-β-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells," 2020, iScience
  • "Fetal and neonatal bilirubin metabolism," 2023, Frontiers in Pediatrics
  • "Environmental and soil characteristics in Ephedra habitats of Uzbekistan," 2020, Journal of Natural Medicines
  • "Endothelial-specific depletion of TGF-β signaling affects lymphatic function," 2021, Inflammation and Regeneration

Frequent collaborators of Susumu Itoh include the following researchers:

  • Hitoshi Okada
  • Kosuke Koyano
  • Takashi Kusaka
  • Shinji Nakamura
  • Etsu Tashiro

Publication venues where Susumu Itoh has multiple contributions include:

  • Annals of Clinical Biochemistry International Journal of Laboratory Medicine
  • Journal of Natural Medicines
  • Pediatrics International
  • Journal of Biological Chemistry
  • Scientific Reports

Best Publications

  • Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

    Atsuhito Nakao;Mozhgan Afrakhte;Anita Morn;Takuya Nakayama

  • Balancing the activation state of the endothelium via two distinct TGF‐β type I receptors

    Marie‐José Goumans;Gudrun Valdimarsdottir;Susumu Itoh;Alexander Rosendahl

  • Activin Receptor-like Kinase (ALK)1 Is an Antagonistic Mediator of Lateral TGFβ/ALK5 Signaling

    Marie José Goumans;Gudrun Valdimarsdottir;Susumu Itoh;Franck Lebrin

  • Signaling of transforming growth factor-β family members through Smad proteins

    Susumu Itoh;Fumiko Itoh;Marie‐José Goumans;Peter ten Dijke

  • Regulation of cell proliferation by Smad proteins.

    Peter Ten Dijke;Marie-José Goumans;Fumiko Itoh;Susumu Itoh

  • Negative regulation of TGF-beta receptor/Smad signal transduction.

    Susumu Itoh;Peter ten Dijke

  • Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs.

    Hiromu Tanimoto;Susumu Itoh;Peter ten Dijke;Tetsuya Tabata

  • The L45 loop in type I receptors for TGF‐β family members is a critical determinant in specifying Smad isoform activation

    Urban Persson;Hiroto Izumi;Serhiy Souchelnytskyi;Susumu Itoh

  • INDUCTION OF INHIBITORY SMAD6 AND SMAD7 MRNA BY TGF-BETA FAMILY MEMBERS

    Mozhgan Afrakhte;Anita Morén;Surinder Jossan;Susumu Itoh

  • Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system.

    H. Harada;E.-I. Takahashi;S. Itoh;K. Harada

  • Stimulation of Id1 Expression by Bone Morphogenetic Protein Is Sufficient and Necessary for Bone Morphogenetic Protein–Induced Activation of Endothelial Cells

    Gudrun Valdimarsdottir;Marie-José Goumans;Alexander Rosendahl;Martijn Brugman

  • Transforming Growth Factor β1 Induces Nuclear Export of Inhibitory Smad7

    Susumu Itoh;Maréne Landström;Annika Hermansson;Fumiko Itoh

  • Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control.

    Hisashi Hashimoto;Kenji Toide;Ryuji Kitamura;Masako Fujita

  • Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells

    Fumiko Itoh;Fumiko Itoh;Susumu Itoh;Susumu Itoh;Marie-José Goumans;Gudrun Valdimarsdottir

  • Elucidation of Smad Requirement in Transforming Growth Factor-β Type I Receptor-induced Responses

    Susumu Itoh;Midory Thorikay;Marcin Kowanetz;Aristidis Moustakas

  • Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads

    Fumiko Itoh;Hironobu Asao;Kazuo Sugamura;Carl-Henrik Heldin

  • Smad7 mediates apoptosis induced by transforming growth factor β in prostatic carcinoma cells

    Maréne Landström;Nils-Erik Heldin;Shizhong Bu;Annika Hermansson

  • TMEPAI, a Transmembrane TGF-β-Inducible Protein, Sequesters Smad Proteins from Active Participation in TGF-β Signaling

    Yukihide Watanabe;Susumu Itoh;Toshiyasu Goto;Eriko Ohnishi

  • The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-beta/Smad signalling.

    Fumiko Itoh;Nullin Divecha;Lenny Brocks;Lauran Oomen

  • TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α

    Anahita Hamidi;Jie Song;Noopur Thakur;Susumu Itoh

Frequent Co-Authors

Tetsuya Kamataki
Tetsuya Kamataki Hokkaido University
Carl-Henrik Heldin
Carl-Henrik Heldin Uppsala University
Marie-José Goumans
Marie-José Goumans Leiden University Medical Center
Peter ten Dijke
Peter ten Dijke Leiden University Medical Center
Masatsugu Ema
Masatsugu Ema Shiga University of Medical Science
Satoru Takahashi
Satoru Takahashi University of Tsukuba
Tsuyoshi Yokoi
Tsuyoshi Yokoi Nagoya University
Tadatsugu Taniguchi
Tadatsugu Taniguchi University of Tokyo
Masaru Okabe
Masaru Okabe Osaka University
Christine L. Mummery
Christine L. Mummery Leiden University Medical Center

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