D-Index & Metrics Best Publications
Genetics and Molecular Biology
Sweden
2022

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Genetics and Molecular Biology D-index 127 Citations 60,726 352 World Ranking 146 National Ranking 1

Research.com Recognitions

Awards & Achievements

2022 - Research.com Genetics and Molecular Biology in Sweden Leader Award

2016 - Fellow of the American Academy of Arts and Sciences

1999 - Member of Academia Europaea

Member of the European Molecular Biology Organization (EMBO)

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Cancer

His primary scientific interests are in Platelet-derived growth factor receptor, Cell biology, Growth factor, Platelet-derived growth factor and Signal transduction. The various areas that Carl-Henrik Heldin examines in his Platelet-derived growth factor receptor study include Molecular biology, Cancer research, Autophosphorylation and Cell culture. His work carried out in the field of Cell biology brings together such families of science as Transforming growth factor, beta 3, Biochemistry, Cell type and Chemotaxis.

His Growth factor research includes themes of Progenitor cell, Endocrinology and Autocrine signalling. His Platelet-derived growth factor research is multidisciplinary, incorporating elements of Epidermal growth factor, Gene expression, In situ hybridization, Immunology and Glioma. Carl-Henrik Heldin has researched Signal transduction in several fields, including Bone morphogenetic protein, Phosphorylation and Ectopic expression.

His most cited work include:

  • TGF-beta signalling from cell membrane to nucleus through SMAD proteins (3313 citations)
  • Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor (1996 citations)
  • Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling (1568 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of investigation include Cell biology, Platelet-derived growth factor receptor, Platelet-derived growth factor, Receptor and Growth factor. Cell biology is a component of his Signal transduction, SMAD, Transforming growth factor, Phosphorylation and Transforming growth factor beta studies. His SMAD research includes elements of R-SMAD, Transcription factor and Bone morphogenetic protein.

His Platelet-derived growth factor receptor research is multidisciplinary, incorporating perspectives in Molecular biology, Cancer research, Receptor tyrosine kinase and Endocrinology. Paracrine signalling is closely connected to Autocrine signalling in his research, which is encompassed under the umbrella topic of Platelet-derived growth factor. His Growth factor research incorporates themes from Cell culture, Epidermal growth factor, Cell growth, Chemotaxis and Platelet.

He most often published in these fields:

  • Cell biology (47.04%)
  • Platelet-derived growth factor receptor (45.35%)
  • Platelet-derived growth factor (26.90%)

What were the highlights of his more recent work (between 2010-2021)?

  • Cell biology (47.04%)
  • Cancer research (19.80%)
  • Transforming growth factor (17.09%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are Cell biology, Cancer research, Transforming growth factor, Signal transduction and Platelet-derived growth factor receptor. His Cell biology study combines topics in areas such as Receptor and Ubiquitin ligase. His work deals with themes such as Cancer cell, Transcription factor, Autocrine signalling and Liver X receptor, which intersect with Transforming growth factor.

His study in Signal transduction is interdisciplinary in nature, drawing from both Cell surface receptor, Tissue homeostasis and Protein kinase A. A large part of his Platelet-derived growth factor receptor studies is devoted to Platelet-derived growth factor. His research in Transforming growth factor beta intersects with topics in TGF beta signaling pathway and Molecular biology.

Between 2010 and 2021, his most popular works were:

  • Regulation of EMT by TGFβ in cancer. (324 citations)
  • Targeting the PDGF signaling pathway in tumor treatment (284 citations)
  • Signaling Receptors for TGF-β Family Members (232 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • DNA

Carl-Henrik Heldin focuses on Cancer research, Signal transduction, Cell biology, Transforming growth factor and Receptor. His studies deal with areas such as Cell migration, Immunology, Cytokine, Tumor progression and Transforming growth factor beta as well as Cancer research. His Signal transduction research focuses on Phosphorylation and how it connects with SUMO protein.

The concepts of his Cell biology study are interwoven with issues in Embryonic stem cell, Epidermal growth factor, Cellular differentiation, Internalization and Ubiquitin ligase. His work in Platelet-derived growth factor receptor, Cell surface receptor and Growth factor receptor is related to Receptor. Carl-Henrik Heldin studies Platelet-derived growth factor which is a part of Platelet-derived growth factor receptor.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

Carl-Henrik Heldin;Kohei Miyazono;Peter ten Dijke.
Nature (1997)

4767 Citations

Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor

Carl-Henrik Heldin;Bengt Westermark.
Physiological Reviews (1999)

3126 Citations

Dimerization of cell surface receptors in signal transduction

Carl-Henrik Heldin.
Cell (1995)

2346 Citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

Atsuhito Nakao;Mozhgan Afrakhte;Anita Morn;Takuya Nakayama.
Nature (1997)

2203 Citations

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus.

Michael D. Waterfield;Geoffrey T. Scrace;Nigel Whittle;Paul Stroobant.
Nature (1983)

1888 Citations

High interstitial fluid pressure — an obstacle in cancer therapy

Carl-Henrik Heldin;Kristofer Rubin;Kristian Pietras;Arne Östman.
Nature Reviews Cancer (2004)

1861 Citations

Non-Smad TGF-β signals

Aristidis Moustakas;Carl-Henrik Heldin.
Journal of Cell Science (2005)

1401 Citations

Smad regulation in TGF-beta signal transduction.

Aristidis Moustakas;Serhiy Souchelnytskyi;Carl-Henrik Heldin.
Journal of Cell Science (2001)

1288 Citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4.

Atsuhito Nakao;Takeshi Imamura;Takeshi Imamura;Serhiy Souchelnytskyi;Masahiro Kawabata.
The EMBO Journal (1997)

1231 Citations

Specificity, diversity, and regulation in TGF-β superfamily signaling

Ester Piek;Carl-Henrik Heldin;Peter Ten Dijke.
The FASEB Journal (1999)

1129 Citations

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