2026 Carl-Henrik Heldin: Molecular Biology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Best Scientists	177	677	620	10	10	685	115642
Molecular Biology	178	38	33	1	1	610	109296

Research.com Recognitions

2026 - Research.com Molecular Biology in Sweden Leader Award
2025 - Research.com Best Scientists Award
2025 - Research.com Molecular Biology in Sweden Leader Award
2024 - Research.com Genetics and Molecular Biology in Sweden Leader Award
2023 - Research.com Molecular Biology in Sweden Leader Award
2022 - Research.com Genetics and Molecular Biology in Sweden Leader Award
2016 - Fellow of the American Academy of Arts and Sciences
1999 - Member of Academia Europaea
Member of the European Molecular Biology Organization (EMBO)
Member of the European Molecular Biology Organization (EMBO)
Member of the European Molecular Biology Organization (EMBO)

Overview

Carl-Henrik Heldin is affiliated with Uppsala University in Sweden and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine with a focus on molecular biology and oncology. Their research spans various subfields including cancer research, cell biology, and biotechnology.

The main topics of work associated with their research include:

TGF-β signaling in diseases
Cancer Cells and Metastasis
Cancer-related Molecular Pathways
Ubiquitin and proteasome pathways
Cancer-related molecular mechanisms research
Proteoglycans and glycosaminoglycans research
Cancer Research and Treatments

Frequent collaborators in their research include:

Aristidis Moustakas (16 collaborations)
Kohei Miyazono (10 collaborations)
Laia Caja (7 collaborations)
Peter ten Dijke (6 collaborations)
Sannie Culbertson (6 collaborations)

The scientist has published in several notable venues, with the most frequent being:

Trends in Biochemical Sciences (6 publications)
Cancers (4 publications)
Cancer Science (3 publications)
Oncogene (2 publications)
International Journal of Molecular Sciences (2 publications)

Selected recent papers include:

Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis, 2020, Cancer Research
Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors, 2020, Bone
TGFβ and EGF signaling orchestrates the AP-1- and p63 transcriptional regulation of breast cancer invasiveness, 2020, Oncogene
Extracellular Vesicles and Transforming Growth Factor β Signaling in Cancer, 2022, Frontiers in Cell and Developmental Biology
The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor β signaling, 2021, Oncogene

The scientist has been recognized with the following awards and honors:

Fellow of the American Academy of Arts and Sciences, 2016
Member of Academia Europaea, 1999
Member of the European Molecular Biology Organization (EMBO)

Best Publications

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

Carl-Henrik Heldin;Kohei Miyazono;Peter ten Dijke

5087
Citations
Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor

Carl-Henrik Heldin;Bengt Westermark

3364
Citations
Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

Atsuhito Nakao;Mozhgan Afrakhte;Anita Morn;Takuya Nakayama

2393
Citations
Dimerization of cell surface receptors in signal transduction

Carl-Henrik Heldin

2375
Citations
Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus.

Michael D. Waterfield;Geoffrey T. Scrace;Nigel Whittle;Paul Stroobant

1965
Citations
Non-Smad TGF-β signals

Aristidis Moustakas;Carl-Henrik Heldin

1520
Citations
Smad regulation in TGF-beta signal transduction.

Aristidis Moustakas;Serhiy Souchelnytskyi;Carl-Henrik Heldin

1399
Citations
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4.

Atsuhito Nakao;Takeshi Imamura;Takeshi Imamura;Serhiy Souchelnytskyi;Masahiro Kawabata

1336
Citations
Specificity, diversity, and regulation in TGF-β superfamily signaling

Ester Piek;Carl-Henrik Heldin;Peter Ten Dijke

1183
Citations
The regulation of TGFβ signal transduction

Aristidis Moustakas;Carl-Henrik Heldin

1143
Citations
Growth factors: Mechanism of action and relation to oncogenes

Carl-Henrik Heldin;Bengt Westermark

1121
Citations
Signaling networks guiding epithelial–mesenchymal transitions during embryogenesis and cancer progression

Aristidis Moustakas;Carl Henrik Heldin

1078
Citations
SIGNAL TRANSDUCTION VIA PLATELET-DERIVED GROWTH FACTOR RECEPTORS

Carl-Henrik Heldin;Arne Östman;Lars Rönnstrand

1064
Citations
Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor.

P Franzén;P ten Dijke;H Ichijo;H Yamashita

993
Citations
cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

Christer Betsholtz;Ann Johnsson;Carl-Henrik Heldin;Bengt Westermark

968
Citations
Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.

K Miyazono;U Hellman;C Wernstedt;C H Heldin

962
Citations
Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor.

Fuyuki Ishikawa;Kohei Miyazono;Kohei Miyazono;Ulf Hellman;Hannes Drexler

931
Citations
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.

Xuri Li;Annica Pontén;Karin Aase;Linda Karlsson

917
Citations
Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

P. ten Dijke;H. Yamashita;T.K. Sampath;A.H. Reddi

913
Citations
Platelet-derived Growth Factor and Its Receptors in Human Glioma Tissue: Expression of Messenger RNA and Protein Suggests the Presence of Autocrine and Paracrine Loops

Monica Hermanson;Keiko Funa;Magdalena Hartman;Lena Claesson-Welsh

889
Citations

Frequent Co-Authors

Bengt Westermark Uppsala University

Kohei Miyazono University of Tokyo

Aristidis Moustakas Uppsala University

Lars Rönnstrand Lund University

Arne Östman Karolinska Institute

Lena Claesson-Welsh Uppsala University

Ulf Hellman Ludwig Cancer Research

Christer Wernstedt Ludwig Cancer Research

Peter ten Dijke Leiden University Medical Center

Christer Betsholtz Uppsala University

External Links

Personal website of Carl-Henrik Heldin

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