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Biology and Biochemistry
Sweden
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
93
Citations
32664
World Ranking
2098
National Ranking
37

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Sweden Leader Award

Overview

Arne Östman is affiliated with the Karolinska Institute in Sweden. Their research primarily focuses on the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a significant emphasis on Oncology, Immunology, Molecular Biology, Pulmonary and Respiratory Medicine, and Cancer Research.

Their work covers a range of topics related to cancer biology and tumor microenvironment dynamics. Key areas of study include:

  • Cancer Cells and Metastasis
  • Cancer Immunotherapy and Biomarkers
  • Single-cell and spatial transcriptomics
  • Peptidase Inhibition and Analysis
  • Lung Cancer Research Studies
  • Immune cells in cancer
  • Cell Image Analysis Techniques

Notable recent papers authored or co-authored by Arne Östman include:

  • "Cytotoxic T-cells mediate exercise-induced reductions in tumor growth", 2020, eLife
  • "Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells", 2020, Cell Death Discovery
  • "Fibroblasts in urothelial bladder cancer define stroma phenotypes that are associated with clinical outcome", 2020, Scientific Reports
  • "Stromal FAP is an independent poor prognosis marker in non-small cell lung adenocarcinoma and associated with p53 mutation", 2021, Lung Cancer
  • "The diverse and complex roles of atypical chemokine receptors in cancer: From molecular biology to clinical relevance and therapy", 2020, Advances in cancer research

Frequent co-authors include:

  • Carina Strell
  • Artur Mezheyeuski
  • Lina Leiss
  • Sara Corvigno
  • Jonas Bergh

Arne Östman's research is often published in well-known scientific venues, with multiple publications in:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancers
  • Frontiers in Immunology
  • Gynecologic Oncology

The focus on cancer-related topics and related fields demonstrates a deep engagement with the tumor microenvironment, immune response to cancer, and molecular pathways influencing cancer progression and treatment responses. Their contributions are part of ongoing efforts to better understand cancer biology and identify therapeutic targets.

Best Publications

  • High interstitial fluid pressure — an obstacle in cancer therapy

    Carl-Henrik Heldin;Kristofer Rubin;Kristian Pietras;Arne Östman

  • Protein detection using proximity-dependent DNA ligation assays

    Simon Fredriksson;Mats Gullberg;Jonas Jarvius;Charlotta Olsson

  • Hallmarks of cancer: interactions with the tumor stroma.

    Kristian Pietras;Arne Östman

  • SIGNAL TRANSDUCTION VIA PLATELET-DERIVED GROWTH FACTOR RECEPTORS

    Carl-Henrik Heldin;Arne Östman;Lars Rönnstrand

  • PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.

    Xuri Li;Annica Pontén;Karin Aase;Linda Karlsson

  • PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.

    Erika Bergsten;Marko Uutela;Xuri Li;Kristian Pietras

  • Protein-tyrosine phosphatases and cancer

    Arne Östman;Carina Hellberg;Frank D. Böhmer

  • Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall.

    Per Lindblom;Holger Gerhardt;Stefan Liebner;Alexandra Abramsson

  • Cancer-associated fibroblasts and tumor growth--bystanders turning into key players.

    Arne Östman;Martin Augsten

  • Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types

    Carl-Henrik Heldin;Gudrun Bäckström;Arne Östman;Annet Hammacher

  • Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors.

    Kristian Pietras;Arne Östman;Mats Sjöquist;Elisabeth Buchdunger

  • PDGF receptors as cancer drug targets

    Kristian Pietras;Tobias Sjöblom;Kristofer Rubin;Carl-Henrik Heldin

  • Inhibitory DNA ligands to platelet-derived growth factor B-chain.

    Louis S. Green;Derek Jellinek;Robert Jenison;Arne Östman

  • Inhibition of PDGF Receptor Signaling in Tumor Stroma Enhances Antitumor Effect of Chemotherapy

    Kristian Pietras;Kristofer Rubin;Tobias Sjöblom;Elisabeth Buchdunger

  • Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?

    Patrick Micke;Arne Östman

  • Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases.

    Arne Östman;Frank-D Böhmer

  • cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules.

    L Claesson-Welsh;A Eriksson;A Morén;L Severinsson

  • PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma

    Arne Östman

  • The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB.

    A Shimizu;K P O'Brien;T Sjöblom;K Pietras

  • A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain

    A Hammacher;U Hellman;A Johnsson;A Ostman

Frequent Co-Authors

Carl-Henrik Heldin
Carl-Henrik Heldin Uppsala University
Kristian Pietras
Kristian Pietras Lund University
Jonas Bergh
Jonas Bergh Karolinska Institute
Bengt Westermark
Bengt Westermark Uppsala University
Monica Nistér
Monica Nistér Karolinska Institute
Lars Egevad
Lars Egevad Karolinska Institute
Fredrik Pontén
Fredrik Pontén Uppsala University
Frank-D. Böhmer
Frank-D. Böhmer Friedrich Schiller University Jena
Karin Jirström
Karin Jirström Lund University
Kristofer Rubin
Kristofer Rubin Uppsala University

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