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Ulf Landegren

Ulf Landegren

D-Index & Metrics

Molecular Biology

D-Index
75
Citations
26933
World Ranking
1176
National Ranking
21

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Ulf Landegren is affiliated with Uppsala University in Sweden and has an extensive research profile primarily in the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus on Medicine. Their publication record includes 36 works in the former and 23 in the latter, highlighting their interdisciplinary expertise.

Their research spans multiple subfields including Molecular Biology, Biomedical Engineering, Radiology, Nuclear Medicine and Imaging, Infectious Diseases, and Cancer Research. Key topics covered in their work involve Biosensors and Analytical Detection, Advanced Biosensing Techniques and Applications, Advanced biosensing and bioanalysis techniques, Cancer Genomics and Diagnostics, Monoclonal and Polyclonal Antibodies Research, Acute Myeloid Leukemia Research, and Advanced Proteomics Techniques and Applications.

Frequent coauthors in their research include:

  • Masood Kamali-Moghaddam
  • Rasel A. Al-Amin
  • Liza Löf
  • Lei Chen
  • Phathutshedzo M. Muthelo

The venues where Ulf Landegren has published regularly include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Analytical Chemistry
  • Nucleic Acids Research
  • Communications Biology
  • Nature Reviews Rheumatology

Some notable recent papers authored or coauthored by Ulf Landegren are:

  • Cancer diagnostics based on plasma protein biomarkers: hard times but great expectations, 2020, Molecular Oncology
  • Ultra-sensitive monitoring of leukemia patients using superRCA mutation detection assays, 2022, Nature Communications
  • Sensitive Measurement of Drug-Target Engagement by a Cellular Thermal Shift Assay with Multiplex Proximity Extension Readout, 2021, Analytical Chemistry
  • A multiplex platform for digital measurement of circular DNA reaction products, 2020, Nucleic Acids Research
  • Surface protein profiling of prostate-derived extracellular vesicles by mass spectrometry and proximity assays, 2022, Communications Biology

Their contributions include advances in biosensing methods, diagnostics especially in cancer genomics and acute myeloid leukemia, using techniques involving monoclonal and polyclonal antibodies, as well as digital and multiplex analytical technologies.

Ulf Landegren has been recognized as a Member of the European Molecular Biology Organization (EMBO), reflecting professional acknowledgment within molecular biology research communities.

Best Publications

  • Direct observation of individual endogenous protein complexes in situ by proximity ligation

    Ola Söderberg;Mats Gullberg;Malin Jarvius;Karin Ridderstråle

  • Protein detection using proximity-dependent DNA ligation assays

    Simon Fredriksson;Mats Gullberg;Jonas Jarvius;Charlotta Olsson

  • A ligase-mediated gene detection technique

    Ulf Landegren;Robert Kaiser;Jane Sanders;Leroy Hood

  • Padlock probes: Circularizing oligonucleotides for localized DNA detection

    Mats Nilsson;Helena Malmgren;Martina Samiotaki;Marek Kwiatkowski

  • Measurement of cell numbers by means of the endogenous enzyme hexosaminidase. Applications to detection of lymphokines and cell surface antigens

    Ulf Landegren

  • Multiplexed genotyping with sequence-tagged molecular inversion probes

    Paul Hardenbol;Johan Banér;Maneesh Jain;Mats Nilsson

  • Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall.

    Per Lindblom;Holger Gerhardt;Stefan Liebner;Alexandra Abramsson

  • Signal amplification of padlock probes by rolling circle replication

    Johan Banér;Mats Nilsson;Maritha Mendel-Hartvig;Ulf Landegren

  • Method of detecting a nucleotide change in nucleic acids

    Ulf Landegren;Leroy Hood

  • Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay

    Ola Söderberg;Karl-Johan Leuchowius;Mats Gullberg;Malin Jarvius

  • Reading Bits of Genetic Information: Methods for Single-Nucleotide Polymorphism Analysis

    Ulf Landegren;Mats Nilsson;Pui-Yan Kwok

  • Cytokine detection by antibody-based proximity ligation

    Mats Gullberg;Sigrún M. Gústafsdóttir;Edith Schallmeiner;Jonas Jarvius

  • Automated DNA diagnostics using an ELISA-based oligonucleotide ligation assay

    Deborah A. Nickerson;Robert Kaiser;Stephen Lappin;Jason A. Stewart

  • DNA Diagnostics--Molecular Techniques and Automation

    U Landegren;R Kaiser;CT Caskey;L Hood

  • In situ genotyping individual DNA molecules by target-primed rolling-circle amplification of padlock probes

    Chatarina Larsson;Jørn Koch;Anders Nygren;George Janssen

  • A deletion in the amelogenin gene (AMG) causes X-linked amelogenesis imperfecta (AIH1).

    Maria Lagerström;Niklas Dahl;Yutaka Nakahori;Yasuo Nakagome

  • Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

    Moritz Schütte;Thomas Risch;Nilofar Abdavi-Azar;Karsten Boehnke

  • In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method.

    Malin Jarvius;Janna Paulsson;Irene Weibrecht;Karl-Johan Leuchowius

  • Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis.

    Tania Szado;Veerle Vanderheyden;Jan B. Parys;Humbert De Smedt

  • Circle-to-circle amplification for precise and sensitive DNA analysis

    Fredrik Dahl;Johan Banér;Mats Gullberg;Maritha Mendel-Hartvig

Frequent Co-Authors

Mats Nilsson
Mats Nilsson Swedish University of Agricultural Sciences
Ola Söderberg
Ola Söderberg Uppsala University
Michael J. Taussig
Michael J. Taussig Babraham Institute
Anders Isaksson
Anders Isaksson Lund University
Ann-Christine Syvänen
Ann-Christine Syvänen Uppsala University
Ulf Pettersson
Ulf Pettersson Uppsala University
Anders Larsson
Anders Larsson Uppsala University
Mathias Uhlén
Mathias Uhlén Royal Institute of Technology
Fredrik Pontén
Fredrik Pontén Uppsala University
Leroy Hood
Leroy Hood University of Washington

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