World's Best Scientists 2026 revealed!
Christer Betsholtz

Christer Betsholtz

Award Badge
Biology and Biochemistry
Sweden
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
126
Citations
86491
World Ranking
484
National Ranking
10

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Sweden Leader Award
  • 2025 - Research.com Biology and Biochemistry in Sweden Leader Award
  • 2023 - Research.com Biology and Biochemistry in Sweden Leader Award
  • 2022 - Research.com Biology and Biochemistry in Sweden Leader Award
  • 2003 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Christer Betsholtz is affiliated with Uppsala University in Sweden, focusing primarily on the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Neuroscience. Their research spans several subfields including Molecular Biology, Neurology, Immunology, Oncology, and Cell Biology.

The primary topics of their scientific contributions include:

  • Barrier Structure and Function Studies
  • Single-cell and spatial transcriptomics
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Angiogenesis and VEGF in Cancer
  • Immune cells in cancer
  • Cancer Cells and Metastasis
  • Congenital heart defects research

Recent publications demonstrate a focus on cellular heterogeneity, immunology, and vascular biology. Notable papers include:

  • "Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination," 2020, Nature Communications
  • "Specification of CNS macrophage subsets occurs postnatally in defined niches," 2022, Nature
  • "Lack of Evidence of Angiotensin-Converting Enzyme 2 Expression and Replicative Infection by SARS-CoV-2 in Human Endothelial Cells," 2021, Circulation
  • "Identification, discrimination and heterogeneity of fibroblasts," 2022, Nature Communications
  • "Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss," 2020, Circulation Research

Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • eLife
  • Nature
  • Circulation Research

Christer Betsholtz collaborates extensively with other researchers. Frequent co-authors are:

  • Liqun He
  • Michael Vanlandewijck
  • Lars Muhl
  • Urban Lendahl
  • Jianping Liu

Throughout their career, Betsholtz has been recognized by notable scientific communities and is a member of the Academia Europaea since 2003 and of the European Molecular Biology Organization (EMBO).

Best Publications

  • VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

    Holger Gerhardt;Matthew Golding;Marcus Fruttiger;Christiana Ruhrberg

  • Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

    Amit Zeisel;Ana B. Muñoz-Manchado;Simone Codeluppi;Peter Lönnerberg

  • Pericytes regulate the blood–brain barrier

    Annika Armulik;Guillem Genové;Maarja A. Mäe;Maya H. Nisancioglu

  • Role of platelet-derived growth factors in physiology and medicine.

    Johanna Andrae;Radiosa Gallini;Christer Betsholtz

  • Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.

    Annika Armulik;Guillem Genové;Christer Betsholtz

  • Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice

    Per Lindahl;Bengt R. Johansson;Per Levéen;Christer Betsholtz

  • Endothelial/Pericyte Interactions

    Annika Armulik;Alexandra Abramsson;Christer Betsholtz

  • Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

    Mats Hellström;Li Kun Phng;Jennifer J. Hofmann;Elisabet Wallgard

  • Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse.

    M Hellström;M Kalén;P Lindahl;A Abramsson

  • Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins.

    Marika J Karkkainen;Paula Haiko;Kirsi Sainio;Juha Partanen

  • Establishment and Dysfunction of the Blood-Brain Barrier

    Zhen Zhao;Amy R. Nelson;Christer Betsholtz;Berislav V. Zlokovic

  • A molecular atlas of cell types and zonation in the brain vasculature

    Michael Vanlandewijck;Michael Vanlandewijck;Liqun He;Maarj A. Andaloussi Mäe;Johanna Andrae

  • Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

    Robert D. Bell;Ethan A. Winkler;Itender Singh;Abhay P. Sagare

  • Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis.

    Mats Hellström;Holger Gerhardt;Holger Gerhardt;Mattias Kalén;Xuri Li

  • Endothelial-pericyte interactions in angiogenesis

    Holger Gerhardt;Christer Betsholtz

  • Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

    P Levéen;M Pekny;S Gebre-Medhin;B Swolin

  • Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis

    Christiana Ruhrberg;Holger Gerhardt;Matthew Golding;Rose Watson

  • Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis

    Konstantin Gaengel;Guillem Genové;Annika Armulik;Christer Betsholtz

  • PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis

    Hans Boström;Karen Willetts;Karen Willetts;Milos Pekny;Per Levéen

  • Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation.

    Per Westermark;Ulla Engstrom;Kenneth H. Johnson;Gunilla T. Westermark

Frequent Co-Authors

Bengt Westermark
Bengt Westermark Uppsala University
Holger Gerhardt
Holger Gerhardt Max Delbrück Center for Molecular Medicine
Carl-Henrik Heldin
Carl-Henrik Heldin Uppsala University
Karl Tryggvason
Karl Tryggvason Karolinska Institute
Per Westermark
Per Westermark Uppsala University
Milos Pekny
Milos Pekny University of Gothenburg
Urban Lendahl
Urban Lendahl Karolinska Institute
Kjell Hultenby
Kjell Hultenby Karolinska Institute
Kari Alitalo
Kari Alitalo University of Helsinki
Ulf Eriksson
Ulf Eriksson AstraZeneca (United Kingdom)

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Pursuing Biology and Biochemistry in the USA opens doors to diverse career options, many of which now offer flexible online study. For those interested in data, technology, and patient records, an online health information management degree can lead to roles in healthcare administration and data analysis.

Nutrition science is another growing field closely related to biochemistry. If you are seeking a budget-friendly, flexible program, consider the cheapest online nutrition degree. This can prepare you for careers in clinical nutrition, wellness coaching, or public health.

For those looking for applied medical roles, training as a diagnostic technician is a strong option. Choosing an online ultrasound tech school equips you for vital positions in medical imaging. Alternatively, accelerated radiology tech programs online offer a fast track into radiologic technology.

These pathways complement biology and biochemistry backgrounds, providing practical routes to in-demand healthcare careers through convenient online study.

Best Scientists Citing Christer Betsholtz

Trending Scientists

Recently Published Articles