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Bertil B. Fredholm

Bertil B. Fredholm

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Medicine
Sweden
2023

D-Index & Metrics

Medicine

D-Index
125
Citations
62889
World Ranking
3078
National Ranking
60

Research.com Recognitions

  • 2023 - Research.com Medicine in Sweden Leader Award

Overview

Bertil B. Fredholm is affiliated with the Karolinska Institute in Sweden and specializes in research within Biochemistry, Genetics and Molecular Biology. Their work spans several related subfields, including Physiology, Molecular Biology, Neurology, Endocrine and Autonomic Systems, and Cellular and Molecular Neuroscience.

The scientist's research focuses extensively on topics such as Adenosine and Purinergic Signaling, Pharmacological Receptor Mechanisms and Effects, Receptor Mechanisms and Signaling, Vagus Nerve Stimulation Research, Neuroscience of respiration and sleep, as well as Neuropeptides and Animal Physiology.

Fredholm's recent publications include:

  • VI. Nomenclature and Classification of Purinoceptors (2020), published in UNC Libraries
  • Why target brain adenosine receptors? A historical perspective (2020), published in Parkinsonism & Related Disorders
  • Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells (2020), published in UNC Libraries
  • Adenosine receptors in GtoPdb v.2021.2 (2021), published in IUPHAR/BPS Guide to Pharmacology CITE
  • Adenosine receptors in GtoPdb v.2023.1 (2023), published in IUPHAR/BPS Guide to Pharmacology CITE

Service in academic collaboration is reflected in the frequent partnerships with other researchers, notably Kenneth A. Jacobson, Ulrich Schwabe, Bruno G. Frenguelli, Rebecca Hills, and Adriaan P. IJzerman.

Fredholm has contributed multiple articles to venues such as UNC Libraries, IUPHAR/BPS Guide to Pharmacology CITE, Parkinsonism & Related Disorders, and Purinergic Signalling, with UNC Libraries and IUPHAR/BPS Guide to Pharmacology CITE being the most frequent publication venues.

Best Publications

  • International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors

    Bertil B. Fredholm;Adriaan P. IJzerman;Kenneth A. Jacobson;Karl-Norbert Klotz

  • Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use

    Bertil B. Fredholm;Karl Bättig;Janet Holmén;Astrid Nehlig

  • International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update

    Bertil B. Fredholm;Adriaan P. IJzerman;Kenneth A. Jacobson;Joel Linden

  • Adenosine receptors as drug targets — what are the challenges?

    Jiang-Fan Chen;Holger K. Eltzschig;Bertil B. Fredholm

  • Adenosine–dopamine receptor–receptor interactions as an integrative mechanism in the basal ganglia

    Sergi Ferré;Kjell Fuxe;Bertil B. Fredholm;Micaela Morelli

  • How does adenosine inhibit transmitter release

    B.B. Fredholm;T.V. Dunwiddie

  • Adenosine and Brain Function

    Bertil B Fredholm;Jiang-Fan Chen;Rodrigo A Cunha;Per Svenningsson

  • Adenosine, an endogenous distress signal, modulates tissue damage and repair

    B B Fredholm

  • Adenosine, Adenosine Receptors and the Actions of Caffeine

    Bertil B. Fredholm

  • Comparative pharmacology of human adenosine receptor subtypes – characterization of stably transfected receptors in CHO cells

    K N Klotz;J Hessling;J Hegler;Christer Owman

  • Structure and function of adenosine receptors and their genes

    Bertil B. Fredholm;Giulia Arslan;Linda Halldner;Björn Kull

  • Stimulation of high-affinity adenosine A2 receptors decreases the affinity of dopamine D2 receptors in rat striatal membranes.

    S Ferre;G von Euler;B Johansson;B B Fredholm

  • Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine

    Zhi-Li Huang;Wei-Min Qu;Naomi Eguchi;Jiang-Fan Chen

  • Modulation of neurotransmission by purine nucleotides and nucleosides.

    Bertil B. Fredholm;Per Hedqvist

  • Distribution, biochemistry and function of striatal adenosine A2A receptors

    Svenningsson P;Le Moine C;Fisone G;Fredholm Bb

  • Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor

    Björn Johansson;Linda Halldner;Thomas V. Dunwiddie;Susan A. Masino

  • Signalling from adenosine receptors to mitogen-activated protein kinases

    Gunnar Schulte;Bertil B. Fredholm

  • Are methylxanthine effects due to antagonism of endogenous adenosine

    Bertil B. Fredholm

  • Neuroprotective role of adenosine in cerebral ischaemia.

    Karl A. Rudolphi;Peter Schubert;Fiona E. Parkinson;Bertil B. Fredholm

  • Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium-derived relaxing factor in the cat.

    Lars Edvinsson;Bertil B. Fredholm;Edith Hamel;Inger Jansen

Frequent Co-Authors

Per Svenningsson
Per Svenningsson Karolinska Institute
Kjell Fuxe
Kjell Fuxe Karolinska Institute
Mikael Jondal
Mikael Jondal Karolinska Institute
Gunnar Schulte
Gunnar Schulte Karolinska Institute
Paul Hjemdahl
Paul Hjemdahl Karolinska University Hospital
Thomas V. Dunwiddie
Thomas V. Dunwiddie University of Colorado Anschutz Medical Campus
Jiang-Fan Chen
Jiang-Fan Chen Boston University
Bengt Persson
Bengt Persson Science for Life Laboratory
Kenneth A. Jacobson
Kenneth A. Jacobson National Institutes of Health
Rodrigo A. Cunha
Rodrigo A. Cunha University of Coimbra

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