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Adriaan P. IJzerman

Adriaan P. IJzerman

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Chemistry
Netherlands
2025
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Biology and Biochemistry
Netherlands
2023

D-Index & Metrics

Chemistry

D-Index
87
Citations
32062
World Ranking
2374
National Ranking
56

Biology and Biochemistry

D-Index
88
Citations
32410
World Ranking
2670
National Ranking
66

Research.com Recognitions

  • 2025 - Research.com Chemistry in Netherlands Leader Award
  • 2023 - Research.com Biology and Biochemistry in Netherlands Leader Award
  • 2022 - Research.com Chemistry in Netherlands Leader Award

Overview

Adriaan P. IJzerman is affiliated with Leiden University in the Netherlands, with a primary focus on biochemistry, genetics, and molecular biology. Their research spans various subfields including molecular biology, cellular and molecular neuroscience, physiology, computational theory and mathematics, and oncology.

The scientist's work prominently addresses receptor mechanisms and signaling, particularly adenosine and purinergic signaling. Their research also encompasses computational drug discovery methods, pharmacological receptor mechanisms and effects, neuropeptides and animal physiology, monoclonal and polyclonal antibodies research, and drug transport and resistance mechanisms.

Adriaan P. IJzerman has contributed to multiple recent publications. Notable papers include:

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors (2021, British Journal of Pharmacology)
  • The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors (2023, British Journal of Pharmacology)
  • The Concise Guide to PHARMACOLOGY 2023/24: Ion channels (2023, British Journal of Pharmacology)
  • International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update (2022, Pharmacological Reviews)
  • DrugEx v2: de novo design of drug molecules by Pareto-based multi-objective reinforcement learning in polypharmacology (2021, Journal of Cheminformatics)

Frequent co-authors collaborating with IJzerman include Laura H. Heitman, Gerard J. P. van Westen, Willem Jespers, Marina Gorostiola González, and Daan van der Es. These collaborations illustrate a network of researchers working closely on related pharmacological topics.

The scientist's research has been published across several well-known venues, with recurrent contributions to the following:

  • IUPHAR/BPS Guide to Pharmacology CITE
  • Biochemical Pharmacology
  • Zenodo (CERN European Organization for Nuclear Research)
  • Journal of Cheminformatics
  • British Journal of Pharmacology

Adriaan P. IJzerman's work integrates experimental and computational approaches, bridging molecular insights with pharmacological applications. This interdisciplinary profile is supported by publications addressing both receptor biology and advanced computational methods for drug discovery.

Best Publications

  • International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors

    Bertil B. Fredholm;Adriaan P. IJzerman;Kenneth A. Jacobson;Karl-Norbert Klotz

  • The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist.

    Veli-Pekka Jaakola;Mark T. Griffith;Michael A. Hanson;Vadim Cherezov

  • International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update

    Bertil B. Fredholm;Adriaan P. IJzerman;Kenneth A. Jacobson;Joel Linden

  • Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

    Wei Liu;Eugene Chun;Aaron A. Thompson;Pavel Chubukov

  • Small molecule absorption by PDMS in the context of drug response bioassays

    B.J. van Meer;H. de Vries;K.S.A. Firth;J. van Weerd

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors

    Stephen P.H. Alexander;Arthur Christopoulos;Anthony P. Davenport;Eamonn Kelly

  • Role of ceramide 1 in the molecular organization of the stratum corneum lipids

    J.A. Bouwstra;G.S. Gooris;F.E.R. Dubbelaar;A.M. Weerheim

  • Beyond the hype: deep neural networks outperform established methods using a ChEMBL bioactivity benchmark set

    Eelke B. Lenselink;Niels ten Dijke;Brandon Bongers;George Papadatos;George Papadatos

  • Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists

    Yi Zheng;Ling Qin;Natalia V. Ortiz Zacarías;Henk de Vries

  • Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery

    Richard A. Bond;Ad P. IJzerman

  • Structure-Based Discovery of Novel Chemotypes for Adenosine A2A Receptor Antagonists

    Vsevolod Katritch;Vsevolod Katritch;Veli-Pekka Jaakola;Veli-Pekka Jaakola;J. Robert Lane;Judy Lin

  • Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation

    M.C. Peeters;G.J.P. van Westen;Q. Li;A.P. IJzerman

  • Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor

    Kerstin Wieland;Helene M. Zuurmond;Cornelius Krasel;Ad P. Ijzerman

  • Pharmacological and biochemical analysis of FPL 67156, a novel, selective inhibitor of ecto-ATPase.

    B.E. Crack;C.E. Pollard;M.W. Beukers;S.M. Roberts

  • Inverse agonism at G protein‐coupled receptors: (patho)physiological relevance and implications for drug discovery

    Rianne A F De Ligt;Angeliki P Kourounakis;Ad P IJzerman

  • International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)

    Stefan Offermanns;Steven L. Colletti;Timothy W. Lovenberg;Graeme Semple

  • New, non-adenosine, high-potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine.

    Margot W Beukers;Lisa C W Chang;Jacobien K von Frijtag Drabbe Künzel;Thea Mulder-Krieger

  • A Binding Site Model and Structure-Activity Relationships for the Rat A3 Adenosine Receptor

    P J van Galen;A H van Bergen;C Gallo-Rodriguez;N Melman

  • Functional efficacy of adenosine A2A receptor agonists is positively correlated to their receptor residence time

    Dong Guo;Thea Mulder-Krieger;Adriaan P IJzerman;Laura H Heitman

  • Kinetics for Drug Discovery: an industry-driven effort to target drug residence time.

    Doris A. Schuetz;Wilhelmus Egbertus Arnout de Witte;Yin Cheong Wong;Bernhard Knasmueller

  • Allosteric modulation of G-protein-coupled receptors

    Ad P IJzerman;Ineke van Wijngaarden;Willem Soudijn

Frequent Co-Authors

Johannes Brussee
Johannes Brussee Leiden University
Meindert Danhof
Meindert Danhof Leiden University
Kenneth A. Jacobson
Kenneth A. Jacobson National Institutes of Health
Andreas Bender
Andreas Bender University of Cambridge
Zhan-Guo Gao
Zhan-Guo Gao National Institutes of Health
Christa E. Müller
Christa E. Müller University of Bonn
Raymond C. Stevens
Raymond C. Stevens University of Southern California
Pier Andrea Borea
Pier Andrea Borea University of Ferrara
Christine L. Mummery
Christine L. Mummery Leiden University Medical Center

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