World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
14579
World Ranking
9182
National Ranking
4069

Overview

Zhan-Guo Gao is affiliated with the National Institutes of Health in the United States. Their research spans across multiple disciplines, primarily focusing on biochemistry, genetics, and molecular biology, with a significant contribution also to medicine. The scientist's work covers a broad spectrum of molecular and physiological aspects, including organic chemistry and cellular neuroscience within the subfields of molecular biology, physiology, organic chemistry, cellular and molecular neuroscience, and cell biology.

The main research topics explored by Zhan-Guo Gao include adenosine and purinergic signaling, receptor mechanisms and signaling, pharmacological receptor mechanisms and effects, adipose tissue and metabolism, synthesis and biological evaluation, telomeres, telomerase, and senescence, along with adipokines, inflammation, and metabolic diseases.

Among the recent published papers by Zhan-Guo Gao are:

  • Age-associated telomere attrition in adipocyte progenitors predisposes to metabolic disease (2020, Nature Metabolism)

Zhan-Guo Gao has collaborated frequently with several scientists, including Kenneth A. Jacobson, Mikhail G. Kolonin, Dilip K. Tosh, Veronica Salmaso, and John A. Auchampach. These coauthor relationships reflect interdisciplinary work that intersects pharmacology, molecular biology, and metabolism.

Their publications have appeared in prominent scientific journals, with multiple contributions to the following venues:

  • Journal of Medicinal Chemistry (10 publications)
  • Purinergic Signalling (5 publications)
  • European Journal of Medicinal Chemistry (5 publications)
  • Diabetes (4 publications)
  • ACS Medicinal Chemistry Letters (4 publications)

Best Publications

  • Adenosine receptors as therapeutic targets

    Kenneth A. Jacobson;Zhan-Guo Gao

  • Structure of an Agonist-Bound Human A2A Adenosine Receptor

    Fei Xu;Huixian Wu;Vsevolod Katritch;Gye Won Han

  • Structure of the human P2Y12 receptor in complex with an antithrombotic drug

    Kaihua Zhang;Jin Zhang;Zhan-Guo Gao;Dandan Zhang

  • Agonist-bound structure of the human P2Y12 receptor

    Jin Zhang;Kaihua Zhang;Zhan-Guo Gao;Silvia Paoletta

  • Two disparate ligand-binding sites in the human P2Y1 receptor

    Dandan Zhang;Zhan-Guo Gao;Kaihua Zhang;Evgeny Kiselev

  • Progress in the pursuit of therapeutic adenosine receptor antagonists.

    Stefano Moro;Zhan-Guo Gao;Kenneth A. Jacobson;Giampiero Spalluto

  • Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor

    Matthew T. Eddy;Ming-Yue Lee;Zhan-Guo Gao;Kate L. White

  • Activation of Th1 and Tc1 cell adenosine A2A receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivo

    Andreas A. Erdmann;Zhan-Guo Gao;Unsu Jung;Jason Foley

  • Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors

    Liaman K Mamedova;Bhalchandra V Joshi;Zhan-Guo Gao;Ivar von Kügelgen

  • N6-Substituted adenosine derivatives: selectivity, efficacy, and species differences at A3 adenosine receptors.

    Zhan-Guo Gao;Joshua B. Blaustein;Ariel S. Gross;Neli Melman

  • Structure–activity relationships of thiazole and thiadiazole derivatives as potent and selective human adenosine A3 receptor antagonists

    Kwan-Young Jung;Soo-Kyung Kim;Zhan-Guo Gao;Ariel S Gross

  • Identification by Site-directed Mutagenesis of Residues Involved in Ligand Recognition and Activation of the Human A3 Adenosine Receptor

    Zhan-Guo Gao;Aishe Chen;Dov Barak;Soo-Kyung Kim

  • Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling.

    Stefano Costanzi;Liaman Mamedova;Zhan-Guo Gao;Kenneth A. Jacobson

  • Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development.

    Kenneth A. Jacobson;Dilip K. Tosh;Shanu Jain;Zhan-Guo Gao

  • Structural Determinants of A3 Adenosine Receptor Activation: Nucleoside Ligands at the Agonist/Antagonist Boundary

    Zhan-Guo Gao;Soo-Kyung Kim;Thibaud Biadatti;Wangzhong Chen

  • Modeling the adenosine receptors: comparison of the binding domains of A2A agonists and antagonists.

    Soo-Kyung Kim;Zhan-Guo Gao;Philippe Van Rompaey;Ariel S Gross

  • Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling.

    Kate L. White;Matthew T. Eddy;Zhan-Guo Gao;Gye Won Han

  • A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy.

    Kenneth A. Jacobson;Stefania Merighi;Katia Varani;Pier Andrea Borea

  • Allosteric modulation of A2A adenosine receptors by amiloride analogues and sodium ions

    Zhan-Guo Gao;Adriaan P Ijzerman

  • Emerging adenosine receptor agonists

    Zhan-Guo Gao;Kenneth A Jacobson

Frequent Co-Authors

Kenneth A. Jacobson
Kenneth A. Jacobson National Institutes of Health
Lak Shin Jeong
Lak Shin Jeong Seoul National University
Raymond C. Stevens
Raymond C. Stevens University of Southern California
Vsevolod Katritch
Vsevolod Katritch University of Southern California
Adriaan P. IJzerman
Adriaan P. IJzerman Leiden University
Stefano Costanzi
Stefano Costanzi American University
Gye Won Han
Gye Won Han University of Southern California
Daniela Salvemini
Daniela Salvemini Saint Louis University
Christa E. Müller
Christa E. Müller University of Bonn
Stefano Moro
Stefano Moro University of Padua

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