D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 53 Citations 11,226 149 World Ranking 8637 National Ranking 649

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Receptor
  • Biochemistry

Karl-Norbert Klotz spends much of his time researching Receptor, Adenosine receptor, Adenosine, Biochemistry and Adenosine A1 receptor. Many of his studies on Receptor apply to Stereochemistry as well. His studies deal with areas such as Endocrinology and Pharmacology as well as Adenosine receptor.

His study in Adenosine is interdisciplinary in nature, drawing from both Cell, Cancer research, Cyclase, Signal transduction and Adenosine receptor antagonist. Biochemistry connects with themes related to Transfection in his study. His Adenosine A1 receptor research is multidisciplinary, relying on both Molecular biology, Cell cycle and Growth factor receptor.

His most cited work include:

  • International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors (2203 citations)
  • Comparative pharmacology of human adenosine receptor subtypes – characterization of stably transfected receptors in CHO cells (704 citations)
  • 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX)--a selective high affinity antagonist radioligand for A1 adenosine receptors. (358 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Adenosine receptor, Receptor, Stereochemistry, Adenosine and Biochemistry. His Adenosine receptor study combines topics in areas such as Adenylyl cyclase and Pharmacology. His Receptor research incorporates elements of Signal transduction and Binding site.

He interconnects Structure–activity relationship and Chemical synthesis in the investigation of issues within Stereochemistry. His work in Adenosine tackles topics such as Adenosine A3 receptor which are related to areas like Purinergic signalling. The concepts of his Agonist study are interwoven with issues in Antagonist and Ligand.

He most often published in these fields:

  • Adenosine receptor (76.92%)
  • Receptor (51.58%)
  • Stereochemistry (43.44%)

What were the highlights of his more recent work (between 2016-2021)?

  • Adenosine receptor (76.92%)
  • Receptor (51.58%)
  • Stereochemistry (43.44%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Adenosine receptor, Receptor, Stereochemistry, Adenosine and Pharmacology. Karl-Norbert Klotz has researched Adenosine receptor in several fields, including Antagonist, Molecular model, Docking and Xanthine. His Receptor study introduces a deeper knowledge of Biochemistry.

His research in Biochemistry intersects with topics in Chalcone and Pathogenesis. His Adenosine research is multidisciplinary, incorporating perspectives in Platelet activation, Platelet, Adenosine A1 receptor and Nucleoside. His studies in Pharmacology integrate themes in fields like In vitro, Agonist, Partial agonist, Parkinson's disease and Dopamine.

Between 2016 and 2021, his most popular works were:

  • Synthesis, adenosine receptor binding and molecular modelling studies of novel thieno[2,3-d]pyrimidine derivatives. (26 citations)
  • 7‐Amino‐2‐aryl/hetero‐aryl‐5‐oxo‐5,8‐dihydro[1,2,4]triazolo[1,5‐a]pyridine‐6‐carbonitriles: Synthesis and adenosine receptor binding studies (19 citations)
  • Synthesis and adenosine receptors binding studies of new fluorinated analogues of pyrido[2,3- d ]pyrimidines and quinazolines (19 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Amino acid
  • Biochemistry

Karl-Norbert Klotz mainly focuses on Adenosine receptor, Adenosine, Stereochemistry, Pharmacology and Ring. His work deals with themes such as Docking and Ligand, which intersect with Adenosine receptor. His studies deal with areas such as Receptor, G protein-coupled receptor, Allosteric regulation, Partial agonist and Tachyphylaxis as well as Adenosine.

His study in Receptor is interdisciplinary in nature, drawing from both Substantia nigra, Neuropathic pain, Dopamine and Medicinal chemistry. His Pharmacology research is multidisciplinary, incorporating elements of Agonist, Dopaminergic, Antagonist, Parkinson's disease and Ischemia. His biological study spans a wide range of topics, including Molecular model and Formalin Test.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors

Bertil B. Fredholm;Adriaan P. IJzerman;Kenneth A. Jacobson;Karl-Norbert Klotz.
Pharmacological Reviews (2001)

3155 Citations

Comparative pharmacology of human adenosine receptor subtypes – characterization of stably transfected receptors in CHO cells

C. Hoffmann;M. R. Leitz;S. Oberdorf-Maass;M. J. Lohse.
Naunyn-schmiedebergs Archives of Pharmacology (1997)

750 Citations

8-Cyclopentyl-1,3-dipropylxanthine (DPCPX)--a selective high affinity antagonist radioligand for A1 adenosine receptors.

Martin J. Lohse;Karl-Norbert Klotz;Jutta Lindenborn-Fotinos;Martin Reddington.
Naunyn-schmiedebergs Archives of Pharmacology (1987)

503 Citations

Adenosine receptors and their ligands.

Karl-Norbert Klotz.
Naunyn-schmiedebergs Archives of Pharmacology (2000)

430 Citations

Analysis of receptor oligomerization by FRAP microscopy.

Sandra Dorsch;Karl-Norbert Klotz;Stefan Engelhardt;Martin J Lohse.
Nature Methods (2009)

254 Citations

2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors.

Martin J. Lohse;Karl-Norbert Klotz;Ulrich Schwabe;Gloria Cristalli.
Naunyn-schmiedebergs Archives of Pharmacology (1988)

233 Citations

Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A2A-Selective adenosine receptor antagonists

Roland Sauer;Juris Maurinsh;Ulrike Reith;Friederike Fülle.
Journal of Medicinal Chemistry (2000)

199 Citations

The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion.

Michael P. Schön;Margarete Schön;Karl-Norbert Klotz.
Journal of Investigative Dermatology (2006)

187 Citations

Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity

Sebastian F. M. Häusler;Itsaso Montalbán del Barrio;Jenny Strohschein;P. Anoop Chandran.
Cancer Immunology, Immunotherapy (2011)

178 Citations

[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors.

Katia Varani;Stefania Merighi;Stefania Gessi;Karl-Norbert Klotz.
Molecular Pharmacology (2000)

171 Citations

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