His primary scientific interests are in Mitochondrion, Biochemistry, Cell biology, NAD+ kinase and Sirtuin 1. His study in Mitochondrion is interdisciplinary in nature, drawing from both Mitochondrial unfolded protein response, Energy homeostasis, Function and Mitochondrial translation. His study in the fields of Sirtuin under the domain of Biochemistry overlaps with other disciplines such as Tafazzin, Cardiolipin, Barth syndrome and Monolysocardiolipin.
His Cell biology study combines topics in areas such as Cell, Glycolysis, Oxidative phosphorylation, Molecular biology and Programmed cell death. His study looks at the relationship between NAD+ kinase and topics such as Cofactor, which overlap with Transcription factor. Calorie restriction, Postprandial, Basal metabolic rate and Resveratrol is closely connected to Adipose tissue in his research, which is encompassed under the umbrella topic of Sirtuin 1.
Mitochondrion, Cell biology, Internal medicine, Endocrinology and Biochemistry are his primary areas of study. His Mitochondrion research includes elements of Function and Mitochondrial translation. His studies in Cell biology integrate themes in fields like Translation, Oxidative phosphorylation and Metabolism.
His work deals with themes such as Cell culture and Cancer stem cell, which intersect with Oxidative phosphorylation. His Biochemistry research focuses on NAD+ kinase, Enzyme, Metabolite and Citric acid cycle. His NAD+ kinase research is multidisciplinary, incorporating perspectives in Sirtuin 1 and Cofactor.
Riekelt H. Houtkooper spends much of his time researching Internal medicine, Endocrinology, Cell biology, Mitochondrion and Lipidomics. His Internal medicine research incorporates elements of Enzyme and Fatty acid. His Cell biology research integrates issues from Lipopolysaccharide, Transcriptome, Longevity, Regulator and Innate immune system.
The various areas that Riekelt H. Houtkooper examines in his Mitochondrion study include Oxidative phosphorylation, Biogenesis, Neuroscience and Mitochondrial translation. While the research belongs to areas of Lipidomics, he spends his time largely on the problem of Circadian rhythm, intersecting his research to questions surrounding Lipid metabolism. His Nicotinamide riboside study is concerned with Biochemistry in general.
Riekelt H. Houtkooper mostly deals with Mitochondrion, Internal medicine, Endocrinology, Cell biology and Glycolysis. His Mitochondrion research focuses on Mitochondrial fission in particular. His Glycogen storage disease study, which is part of a larger body of work in Endocrinology, is frequently linked to Very low-density lipoprotein, bridging the gap between disciplines.
His biological study spans a wide range of topics, including RNA, RNA interference, Apoptosis, Mitochondrial translation and Regulator. As part of one scientific family, Riekelt H. Houtkooper deals mainly with the area of Glycolysis, narrowing it down to issues related to the Leukocyte extravasation, and often Metabolism. The study incorporates disciplines such as Lipidome, Lipidomics, Circadian clock, Insulin resistance and NAD+ kinase in addition to Skeletal muscle.
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Sirtuins as regulators of metabolism and healthspan
Riekelt H. Houtkooper;Eija Pirinen;Eija Pirinen;Johan Auwerx.
Nature Reviews Molecular Cell Biology (2012)
Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans
Silvie Timmers;Ellen Konings;Lena Bilet;Riekelt H. Houtkooper.
Cell Metabolism (2011)
The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet induced obesity
Carles Cantó;Riekelt H. Houtkooper;Eija Pirinen;Eija Pirinen;Dou Y. Youn.
Cell Metabolism (2012)
Mitonuclear protein imbalance as a conserved longevity mechanism
Riekelt H. Houtkooper;Laurent Mouchiroud;Dongryeol Ryu;Norman Moullan.
Nature (2013)
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways.
Riekelt H. Houtkooper;Carles Cantó;Ronald J. Wanders;Johan Auwerx.
Endocrine Reviews (2010)
The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
Laurent Mouchiroud;Riekelt H. Houtkooper;Norman Moullan;Elena Katsyuba.
Cell (2013)
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
Péter Bai;Péter Bai;Carles Cantó;Hugues Oudart;Attila Brunyánszki.
Cell Metabolism (2011)
Cardiolipin, the heart of mitochondrial metabolism.
R. H. Houtkooper;F. M. Vaz.
Cellular and Molecular Life Sciences (2008)
Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research.
Norman Moullan;Laurent Mouchiroud;Xu Wang;Dongryeol Ryu.
Cell Reports (2015)
The metabolic footprint of aging in mice
Riekelt H. Houtkooper;Carmen Argmann;Sander M. Houten;Carles Cantó.
Scientific Reports (2011)
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