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Riekelt H. Houtkooper

Riekelt H. Houtkooper

D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
24856
World Ranking
7642
National Ranking
197

Overview

Riekelt H. Houtkooper is affiliated with the University of Amsterdam in the Netherlands. Their research is situated primarily within biochemistry, genetics, and molecular biology, as well as medicine, encompassing a total of 187 and 154 publications in these fields respectively.

Their work spans several interconnected subfields, including molecular biology, physiology, aging, immunology, and clinical biochemistry. Key research topics focus on mitochondrial function and pathology, genetics related to aging and longevity in model organisms, adipose tissue and metabolism, metabolism and genetic disorders, diet and metabolism studies, circadian rhythm and melatonin, and sirtuins and resveratrol in medicine.

Frequent co-authors of Riekelt H. Houtkooper include Michel van Weeghel, Georges E. Janssens, Bauke V. Schomakers, Frédéric M. Vaz, and Arwen W. Gao, reflecting collaborative research efforts.

They have published extensively in various scientific venues. The most frequent publication venues are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Scientific Reports
  • iScience
  • EMBO Molecular Medicine

Recent notable papers by the scientist include:

  • "Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease" (2020), Mechanisms of Ageing and Development
  • "Mitochondria-associated programmed cell death as a therapeutic target for age-related disease" (2023), Experimental & Molecular Medicine
  • "NAD + homeostasis in human health and disease" (2021), EMBO Molecular Medicine
  • "Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation" (2020), Circulation Research
  • "Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans" (2020), American Journal of Clinical Nutrition

Best Publications

  • Sirtuins as regulators of metabolism and healthspan

    Riekelt H. Houtkooper;Eija Pirinen;Eija Pirinen;Johan Auwerx

  • Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

    Silvie Timmers;Ellen Konings;Lena Bilet;Riekelt H. Houtkooper

  • The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet induced obesity

    Carles Cantó;Riekelt H. Houtkooper;Eija Pirinen;Eija Pirinen;Dou Y. Youn

  • The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

    Laurent Mouchiroud;Riekelt H. Houtkooper;Norman Moullan;Elena Katsyuba

  • Mitonuclear protein imbalance as a conserved longevity mechanism

    Riekelt H. Houtkooper;Laurent Mouchiroud;Dongryeol Ryu;Norman Moullan

  • The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways.

    Riekelt H. Houtkooper;Carles Cantó;Ronald J. Wanders;Johan Auwerx

  • PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

    Péter Bai;Péter Bai;Carles Cantó;Hugues Oudart;Attila Brunyánszki

  • The metabolic footprint of aging in mice

    Riekelt H. Houtkooper;Carmen Argmann;Sander M. Houten;Carles Cantó

  • Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease.

    Reuben L Smith;Maarten R Soeters;Rob C I Wüst;Riekelt H Houtkooper

  • Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research.

    Norman Moullan;Laurent Mouchiroud;Xu Wang;Dongryeol Ryu

  • Cardiolipin, the heart of mitochondrial metabolism.

    R. H. Houtkooper;F. M. Vaz

  • Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

    Michalina Janiszewska;Mario L. Suvà;Nicolo Riggi;Riekelt H. Houtkooper;Riekelt H. Houtkooper

  • Pharmacological approaches to restore mitochondrial function

    Pénélope A. Andreux;Riekelt H. Houtkooper;Johan Auwerx

  • Cardiolipin provides an essential activating platform for caspase-8 on mitochondria.

    Francois Gonzalvez;Zachary T. Schug;Riekelt H. Houtkooper;Elaine D. MacKenzie

  • Microbial stimulation of different Toll-like receptor signalling pathways induces diverse metabolic programmes in human monocytes

    Ekta Lachmandas;Lily Boutens;Lily Boutens;Jacqueline M. Ratter;Jacqueline M. Ratter;Anneke Hijmans

  • Laminar Shear Stress Inhibits Endothelial Cell Metabolism via KLF2-Mediated Repression of PFKFB3

    Anuradha Doddaballapur;Katharina M. Michalik;Yosif Manavski;Tina Lucas

  • Cardiac and Skeletal Muscle Defects in a Mouse Model of Human Barth Syndrome

    Devrim Acehan;Frederic Vaz;Riekelt H. Houtkooper;Jeanne James

  • Disorders of mitochondrial long-chain fatty acid oxidation and the carnitine shuttle

    Suzan J. G. Knottnerus;Suzan J. G. Knottnerus;Jeannette C. Bleeker;Jeannette C. Bleeker;Rob C. I. Wüst;Sacha Ferdinandusse

  • Metabolic Networks of Longevity

    Riekelt H. Houtkooper;Robert W. Williams;Johan Auwerx

  • Mutations in LPIN1 Cause Recurrent Acute Myoglobinuria in Childhood

    Avraham Zeharia;Avraham Zeharia;Avraham Shaag;Riekelt H. Houtkooper;Tareq Hindi

Frequent Co-Authors

Frédéric M. Vaz
Frédéric M. Vaz University of Amsterdam
Johan Auwerx
Johan Auwerx École Polytechnique Fédérale de Lausanne
Ronald J.A. Wanders
Ronald J.A. Wanders University of Amsterdam
Carles Cantó
Carles Cantó Nestlé (Switzerland)
Sacha Ferdinandusse
Sacha Ferdinandusse University of Amsterdam
Patrick Schrauwen
Patrick Schrauwen Maastricht University
Frits A. Wijburg
Frits A. Wijburg University of Amsterdam
Sander M. Houten
Sander M. Houten Icahn School of Medicine at Mount Sinai
Hans R. Waterham
Hans R. Waterham University of Amsterdam
Lodewijk IJlst
Lodewijk IJlst University of Amsterdam

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