D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 64 Citations 14,316 181 World Ranking 6262 National Ranking 2954

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • DNA

Charles Brenner mostly deals with Biochemistry, NAD+ kinase, Nicotinamide riboside, Enzyme and Nicotinamide. His is doing research in Histidine, FHIT, Gene, Binding site and Biosynthesis, both of which are found in Biochemistry. His studies deal with areas such as Calorie restriction, Niacinamide and Niacin as well as NAD+ kinase.

His Nicotinamide riboside research includes elements of Peripheral neuropathy, Diabetes mellitus, Insulin resistance, Diabetic neuropathy and Type 2 diabetes. His Nicotinamide research includes themes of Nicotinamide adenine dinucleotide and Cofactor. His research investigates the connection between Cofactor and topics such as Metabolism that intersect with issues in Riboside, Vitamin, Metabolome and Nicotinic agonist.

His most cited work include:

  • p53 Activation by Knockdown Technologies (863 citations)
  • NAD+ metabolism in health and disease. (674 citations)
  • Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans (444 citations)

What are the main themes of his work throughout his whole career to date?

Charles Brenner spends much of his time researching Biochemistry, NAD+ kinase, Nicotinamide riboside, Enzyme and Nicotinamide. In his study, Active site and Adenosine is strongly linked to Stereochemistry, which falls under the umbrella field of Biochemistry. He has researched NAD+ kinase in several fields, including Metabolome, Cofactor, Metabolism and Cell biology.

His Nicotinamide riboside study incorporates themes from Vitamin, Endocrinology, Internal medicine, Riboside and Pharmacology. His research is interdisciplinary, bridging the disciplines of Binding site and Enzyme. Charles Brenner studies Nicotinamide, namely Nicotinamidase.

He most often published in these fields:

  • Biochemistry (53.30%)
  • NAD+ kinase (46.70%)
  • Nicotinamide riboside (35.03%)

What were the highlights of his more recent work (between 2017-2021)?

  • NAD+ kinase (46.70%)
  • Nicotinamide riboside (35.03%)
  • Nicotinamide adenine dinucleotide (17.26%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in NAD+ kinase, Nicotinamide riboside, Nicotinamide adenine dinucleotide, Cell biology and Endocrinology. His NAD+ kinase research incorporates elements of Proinflammatory cytokine, Metabolome, Molecular biology and Nicotinamide. His work deals with themes such as Retinal degeneration, DNA damage, Vitamin, Pharmacology and Metabolism, which intersect with Nicotinamide riboside.

His Nicotinamide adenine dinucleotide research is classified as research in Biochemistry. His biological study focuses on Signal transduction. His biological study spans a wide range of topics, including Repressor, Nicotinamide mononucleotide and Enzyme.

Between 2017 and 2021, his most popular works were:

  • Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice. (103 citations)
  • Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. (76 citations)
  • A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects (76 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • DNA

His primary scientific interests are in NAD+ kinase, Nicotinamide riboside, Nicotinamide adenine dinucleotide, Cell biology and Internal medicine. His work focuses on many connections between NAD+ kinase and other disciplines, such as Metabolome, that overlap with his field of interest in Metabolism and Nicotinamide. His Nicotinamide riboside research is multidisciplinary, relying on both Autophagy, Biogenesis, Clinical trial, DNA damage and Vitamin.

DNA damage is a subfield of Biochemistry that Charles Brenner investigates. The study incorporates disciplines such as Inflammation, White adipose tissue, Nicotinamide mononucleotide and Enzyme in addition to Cell biology. His work in Internal medicine covers topics such as Mitochondrion which are related to areas like Niacin.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

p53 Activation by Knockdown Technologies

Mara E Robu;Jon D Larson;Aidas Nasevicius;Aidas Nasevicius;Soraya Beiraghi.
PLOS Genetics (2005)

1135 Citations

NAD+ metabolism in health and disease.

Peter Belenky;Katrina L. Bogan;Charles Brenner.
Trends in Biochemical Sciences (2007)

901 Citations

Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans

Pawel Bieganowski;Charles Brenner.
Cell (2004)

543 Citations

Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast.

Ainslie B. Parsons;Andres Lopez;Inmar E. Givoni;David E. Williams.
Cell (2006)

520 Citations

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition

Katrina L. Bogan;Charles Brenner.
Annual Review of Nutrition (2008)

483 Citations

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

Samuel A. J. Trammell;Mark S. Schmidt;Benjamin J. Weidemann;Philip Redpath.
Nature Communications (2016)

443 Citations

GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction

Ikuko Miyajima;Masato Nakafuku;Naoki Nakayama;Charles Brenner.
Cell (1987)

410 Citations

The nitrilase superfamily: classification, structure and function

Helen C Pace;Charles Brenner.
Genome Biology (2001)

401 Citations

Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+

Peter Belenky;Frances G. Racette;Katrina L. Bogan;Julie M. McClure.
Cell (2007)

392 Citations

Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases.

Charles Brenner.
Biochemistry (2002)

310 Citations

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