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Biology and Biochemistry

D-Index
71
Citations
19555
World Ranking
6586
National Ranking
3069

Overview

Charles Brenner is affiliated with the City Of Hope National Medical Center in the United States. Their research focuses primarily on the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with contributions also spanning subfields such as Physiology, Molecular Biology, Geriatrics and Gerontology, Epidemiology, and Oncology.

The scientist has contributed to several key topics within the biomedical sciences, including:

  • Sirtuins and Resveratrol in Medicine
  • Calcium signaling and nucleotide metabolism
  • Adipose Tissue and Metabolism
  • Genetics, Aging, and Longevity in Model Organisms
  • Autophagy in Disease and Therapy
  • Mitochondrial Function and Pathology
  • PARP inhibition in cancer therapy

Charles Brenner's publication record includes multiple papers in top-tier journals. Recent notable papers include:

  • "Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages," 2020, Nature Metabolism
  • "Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy," 2020, Cell Metabolism
  • "Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity," 2020, Journal of Biological Chemistry
  • "NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging," 2020, Molecular Cell
  • "Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study," 2023, Science Advances

The scientist frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Metabolism, Journal of Biological Chemistry, Cell Metabolism, and Science. Their most common publication venue is bioRxiv with 10 publications, followed by Nature Metabolism with 6.

Collaborative work is a significant part of their scholarly output. Frequent coauthors include:

  • Mark S. Schmidt
  • Eija Pirinen
  • Collin D. Heer
  • Antti Hakkarainen
  • Nina Lundbom

Best Publications

  • p53 Activation by Knockdown Technologies

    Mara E Robu;Jon D Larson;Aidas Nasevicius;Aidas Nasevicius;Soraya Beiraghi

  • NAD+ metabolism in health and disease.

    Peter Belenky;Katrina L. Bogan;Charles Brenner

  • Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans

    Pawel Bieganowski;Charles Brenner

  • Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition

    Katrina L. Bogan;Charles Brenner

  • Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

    Samuel A. J. Trammell;Mark S. Schmidt;Benjamin J. Weidemann;Philip Redpath

  • Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast.

    Ainslie B. Parsons;Andres Lopez;Inmar E. Givoni;David E. Williams

  • The nitrilase superfamily: classification, structure and function

    Helen C Pace;Charles Brenner

  • Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+

    Peter Belenky;Frances G. Racette;Katrina L. Bogan;Julie M. McClure

  • GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction

    Ikuko Miyajima;Masato Nakafuku;Naoki Nakayama;Charles Brenner

  • Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.

    Yasir S. Elhassan;Yasir S. Elhassan;Katarina Kluckova;Rachel S. Fletcher;Mark S. Schmidt

  • Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases.

    Charles Brenner

  • NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

    Joanna Ratajczak;Magali Joffraud;Samuel A. J. Trammell;Rosa Ras

  • Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice

    Samuel A.J. Trammell;Benjamin J. Weidemann;Ankita Chadda;Matthew S. Yorek

  • Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging.

    Shogo Sato;Guiomar Solanas;Francisca Oliveira Peixoto;Leonardo Bee

  • Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice

    Sarah J. Mitchell;Michel Bernier;Miguel A. Aon;Sonia Cortassa

  • Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy

    Nicolas Diguet;Samuel A.J. Trammell;Cynthia Tannous;Cynthia Tannous;Robin Deloux;Robin Deloux

  • Catalysis in the nitrilase superfamily.

    Charles Brenner

  • Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages.

    Anthony J. Covarrubias;Anthony J. Covarrubias;Abhijit Kale;Rosalba Perrone;Jose Alberto Lopez-Dominguez

  • Structural and enzymatic characterization of a purified prohormone-processing enzyme: secreted, soluble Kex2 protease.

    Charles Brenner;Robert S. Fuller

  • Arabidopsis VTC2 Encodes a GDP-l-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants

    Carole L. Linster;Tara A. Gomez;Kathryn C. Christensen;Lital N. Adler

Frequent Co-Authors

Eric Verdin
Eric Verdin Buck Institute for Research on Aging
Robert S. Fuller
Robert S. Fuller University of Michigan–Ann Arbor
Hiroshi Okamoto
Hiroshi Okamoto University of Tokyo
Kay Huebner
Kay Huebner The Ohio State University
Melanie Ott
Melanie Ott Gladstone Institutes
Haruhiro Higashida
Haruhiro Higashida Kanazawa University
Judith Campisi
Judith Campisi Buck Institute for Research on Aging
Stanley Perlman
Stanley Perlman University of Iowa
Stephen R. Quake
Stephen R. Quake Stanford University
Carlo M. Croce
Carlo M. Croce The Ohio State University

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