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Genetics

D-Index
74
Citations
17334
World Ranking
1978
National Ranking
903

Overview

John K. Cowell is affiliated with Augusta University in the United States. Their research focuses primarily on medical and molecular biology fields, with significant contributions in hematology, immunology, rheumatology, and genetics. Over their career, they have published extensively on topics including eosinophilic disorders and syndromes, chronic myeloid leukemia treatments, fibroblast growth factor research, acute myeloid leukemia research, immune cells in cancer, myeloproliferative neoplasms diagnosis and treatment, and immune cell function and interaction.

Their recent published papers illustrate a focus on hematological malignancies, leukemia progression, and mechanisms of immune evasion. Notable papers include:

  • "IRAK1-regulated IFN-γ signaling induces MDSC to facilitate immune evasion in FGFR1-driven hematological malignancies" (2021, Molecular Cancer)
  • "Downregulation of PUMA underlies resistance to FGFR1 inhibitors in the stem cell leukemia/lymphoma syndrome" (2020, Cell Death and Disease)
  • "Targeting the WASF3 complex to suppress metastasis" (2022, Pharmacological Research)
  • "RHOA-regulated IGFBP2 promotes invasion and drives progression of BCR-ABL1 chronic myeloid leukemia" (2022, Haematologica)
  • "Single-cell analysis defines highly specific leukemia-induced neutrophils and links MMP8 expression to recruitment of tumor associated neutrophils during FGFR1 driven leukemogenesis" (2024, Experimental Hematology and Oncology)

Publications by John K. Cowell have appeared frequently in venues such as Cancer Research, Clinical Lymphoma Myeloma & Leukemia, Molecular Cancer, Cell Death and Disease, and Pharmacological Research. The most frequent publication venues include:

  • Cancer Research
  • Clinical Lymphoma Myeloma & Leukemia
  • Molecular Cancer
  • Cell Death and Disease
  • Pharmacological Research

John K. Cowell collaborates regularly with several researchers, highlighting ongoing partnerships in their field. Frequent coauthors include:

  • Tianxiang Hu
  • Xuexiu Fang
  • Atsuko Matsunaga
  • Baohuan Cai
  • Yating Chong

The main fields of study reflect a multi-disciplinary approach bridging clinical medicine and molecular biology. Contributions to medicine and biochemistry, genetics, and molecular biology are evident. Their work engages with subfields such as molecular biology, hematology, immunology, rheumatology, and genetics, providing insights into mechanisms of blood cancers and immune system interactions.

The research topics addressed cover a range of hematological conditions and molecular pathways, with a notable focus on:

  • Eosinophilic Disorders and Syndromes
  • Chronic Myeloid Leukemia Treatments
  • Fibroblast Growth Factor Research
  • Acute Myeloid Leukemia Research
  • Immune cells in cancer
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Immune Cell Function and Interaction

Best Publications

  • Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series

    Meizan Lai;Maartje G M Huijbers;Eric Lancaster;Francesc Graus

  • Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues

    J. Scott;John Kenneth Cowell;M. E. Robertson;L. M. Priestley

  • Double minutes and homogeneously staining regions: gene amplification in mammalian cells

    John K. Cowell

  • Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

    Maria Ouzounova;Eunmi Lee;Raziye Piranlioglu;Abdeljabar El Andaloussi

  • The TACC domain identifies a family of centrosomal proteins that can interact with microtubules

    Fanni Gergely;Christina Karlsson;Christina Karlsson;Ivan Still;John Cowell

  • Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA

    Seiji Kondo;Yasuko Kondo;Guiying Li;Robert H Silverman

  • Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01.

    Andrew B. Lassman;Michael R. Rossi;Jeffrey R. Razier;Lauren E. Abrey

  • Antisense telomerase treatment: induction of two distinct pathways, apoptosis and differentiation

    Seiji Kondo;Yoshikazu Tanaka;Yasuko Kondo;Masahiro Hitomi

  • Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model

    F E Cotter;P Johnson;P Hall;C Pocock

  • A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors.

    Olga B. Chernova;Robert P.T. Somerville;John K. Cowell

  • Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis.

    Yasuko Kondo;Seiji Kondo;Yoshikazu Tanaka;Talat Haqqi

  • Expression of oligodendrocyte progenitor cell antigens by gliomas: Implications for the histogenesis of brain tumors

    Yigal Shoshan;Akiko Nishiyama;Akiko Nishiyama;Ansi Chang;Sverre Mörk

  • Evaluating human cancer cell metastasis in zebrafish

    Yong Teng;Xiayang Xie;Steven Walker;David T White

  • Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability.

    Yurij Ionov;Norma Nowak;Manuel Perucho;Sanford Markowitz

  • The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines.

    Ivan H. Still;Pauline Vince;John Kenneth Cowell

  • Tumour suppressor genes

    J. K. Cowell

  • The involvement of JAK-STAT3 in cell motility, invasion, and metastasis.

    Yong Teng;James L Ross;John K Cowell

  • Oncogenic point mutations in exon 20 of the RB1 gene in families showing incomplete penetrance and mild expression of the retinoblastoma phenotype.

    Zerrin Onadim;Annette Hogg;Paul N. Baird;John K. Cowell

  • Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon.

    Ivan H Still;Mark Hamilton;Pauline Vince;Alan Wolfman

  • A role for p300/CREB binding protein genes in promoting cancer progression in colon cancer cell lines with microsatellite instability.

    Yurij Ionov;Sei Ichi Matsui;John K. Cowell

Frequent Co-Authors

Norma J. Nowak
Norma J. Nowak University at Buffalo, State University of New York
Paul N. Baird
Paul N. Baird University of Melbourne
Gene H. Barnett
Gene H. Barnett Cleveland Clinic
Antonio Baldini
Antonio Baldini University of Naples Federico II
William S. Dynan
William S. Dynan Emory University
Akiko Nishiyama
Akiko Nishiyama University of Connecticut
Muthusamy Thangaraju
Muthusamy Thangaraju Augusta University
Ali S. Arbab
Ali S. Arbab Augusta University
Robert H. Silverman
Robert H. Silverman Kent State University
Bruce A. Roe
Bruce A. Roe University of Oklahoma

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