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David E. Housman

David E. Housman

Award Badge
Genetics
USA
2026

D-Index & Metrics

Genetics

D-Index
139
Citations
100094
World Ranking
185
National Ranking
95

Research.com Recognitions

  • 2026 - Research.com Genetics in United States Leader Award
  • 2025 - Research.com Genetics in United States Leader Award
  • 2024 - Research.com Genetics in United States Leader Award
  • 2023 - Research.com Genetics in United States Leader Award
  • 1997 - Member of the National Academy of Medicine (NAM)
  • 1994 - Fellow of the American Academy of Microbiology Genetics and Molecular Biology
  • 1994 - Member of the National Academy of Sciences
  • 1988 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

David E. Housman is affiliated with MIT in the United States and has contributed extensively to research in biochemistry, genetics, molecular biology, and neuroscience. Their work spans various specialized subfields, including molecular biology, cellular and molecular neuroscience, cancer research, immunology, and oncology.

The scientist's research topics cover diverse areas such as cancer, lipids, and metabolism; genetic neurodegenerative diseases; neurotransmitter receptor influence on behavior; mitochondrial function and pathology; peroxisome proliferator-activated receptors; cancer, hypoxia, and metabolism; and viral-associated cancers and disorders.

David E. Housman has coauthored publications with several frequent collaborators:

  • Christopher Ng
  • Jill R. Crittenden
  • Anne C. Smith
  • Ann M. Graybiel
  • Gino B. Ferraro

Their work has appeared in multiple scholarly venues, with a notable concentration in:

  • Proceedings of the National Academy of Sciences
  • Nature Cancer
  • Neurobiology of Disease
  • European Journal of Neuroscience
  • Neuron

Recent scientific publications include:

  • Fatty acid synthesis is required for breast cancer brain metastasis, 2021, Nature Cancer
  • Tenofovir prodrugs potently inhibit Epstein-Barr virus lytic DNA replication by targeting the viral DNA polymerase, 2020, Proceedings of the National Academy of Sciences
  • CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors, 2021, Neurobiology of Disease
  • Striatal transcriptome changes linked to drug-induced repetitive behaviors, 2021, European Journal of Neuroscience
  • CD4 T cells restricted to DRB1*15:01 recognize two Epstein-Barr virus glycoproteins capable of intracellular antigen presentation, 2024, Proceedings of the National Academy of Sciences

Over their career, David E. Housman has received several honors:

  • Member of the National Academy of Sciences, 1994
  • Member of the National Academy of Medicine (NAM), 1997
  • Fellow of the American Academy of Microbiology (Genetics and Molecular Biology), 1994
  • Fellow of the American Association for the Advancement of Science (AAAS), 1988

Best Publications

  • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

    Marcy E. MacDonald;Christine M. Ambrose;Mabel P. Duyao;Richard H. Myers

  • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

    M Shah;N Datson;L Srinidhi;VP Stanton

  • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

    S W Lowe;H E Ruley;T Jacks;D E Housman

  • Molecular basis of myotonic dystrophy: Expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member

    J. David Brook;Mila E. McCurrach;Helen G. Harley;Alan J. Buckler

  • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

    Thomas G. Graeber;Cynthia Osmanian;Tyler Jacks;David E. Housman

  • WT-1 is required for early kidney development

    Jordan A. Kreidberg;Hannu Sariola;Janet M. Loring;Masahiro Maeda

  • Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus.

    Katherine M. Call;Thomas M Glaser;Caryn Y. Ito;Alan J. Buckler

  • Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor

    Jeffrey L. Arriza;Jeffrey L. Arriza;Cary Weinberger;Gail Cerelli;Thomas M Glaser

  • p53 status and the efficacy of cancer therapy in vivo

    SW Lowe;S Bodis;A McClatchey;L Remington

  • The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene.

    Edwin N. Geissler;Melanie A. Ryan;David E. Housman

  • A family of cAMP-binding proteins that directly activate Rap1.

    Hiroaki Kawasaki;Gregory M. Springett;Naoki Mochizuki;Shinichiro Toki

  • High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones.

    Peter Lichter;Chieh-Ju Chang Tang;Katherine Call;Gary Hermanson

  • Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

    Joan S. Steffan;Laszlo Bodai;Judit Pallos;Marnix Poelman

  • Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

    Philippe Gros;James Croop;James Croop;David Housman

  • The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.

    Joan S. Steffan;Aleksey Kazantsev;Olivera Spasic-Boskovic;Marilee Greenwald

  • Isolation and expression of a complementary DNA that confers multidrug resistance.

    Philippe Gros;Yinon Ben Neriah;Yinon Ben Neriah;James M. Croop;David E. Housman

  • Bipolar affective disorders linked to DNA markers on chromosome 11.

    Janice A. Egeland;Daniela S. Gerhard;Daniela S. Gerhard;David L. Pauls;James N. Sussex

  • Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome.

    Jerry Pelletier;Jerry Pelletier;Wendy Bruening;Clifford E. Kashtan;S. Michael Mauer

  • Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset

    Nancy S. Wexler;Judith Lorimer;Julie Porter;Fidela Gomez

  • The candidate Wilms' tumour gene is involved in genitourinary development

    Kathryn Pritchard-Jones;Stewart Fleming;Duncan Davidson;Wendy Bickmore

Frequent Co-Authors

James F. Gusella
James F. Gusella Harvard University
Jerry Pelletier
Jerry Pelletier McGill University
Daniel A. Haber
Daniel A. Haber Harvard University
Thomas M Glaser
Thomas M Glaser University of California, Davis
Stylianos E. Antonarakis
Stylianos E. Antonarakis University of Geneva
Leslie M. Thompson
Leslie M. Thompson University of California, Irvine
Gerald Nestadt
Gerald Nestadt Johns Hopkins University School of Medicine
Ann E. Pulver
Ann E. Pulver Johns Hopkins University School of Medicine
Haig H. Kazazian
Haig H. Kazazian Johns Hopkins University School of Medicine

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