World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
120
Citations
53793
World Ranking
379
National Ranking
192

Medicine

D-Index
120
Citations
54121
World Ranking
3747
National Ranking
2062

Research.com Recognitions

  • 2008 - William Allan Award, the American Society of Human Genetics
  • 2007 - Fellow of the American Academy of Arts and Sciences

Overview

Haig H. Kazazian was affiliated with Johns Hopkins University School of Medicine in the United States. Their research spanned multiple areas within biochemistry, genetics, molecular biology, and medicine, with notable emphasis on genetics and molecular biology.

The scientist contributed extensively to topics related to chromosomal and genetic variations, CRISPR and genetic engineering, virus-based gene therapy research, genomic variations and chromosomal abnormalities, hemophilia treatment and research, genomics and phylogenetic studies, and viral infectious diseases and gene expression in insects.

  • Chromosomal and Genetic Variations
  • CRISPR and Genetic Engineering
  • Virus-based gene therapy research
  • Genomic variations and chromosomal abnormalities
  • Hemophilia Treatment and Research
  • Genomics and Phylogenetic Studies
  • Viral Infectious Diseases and Gene Expression in Insects

Their frequent coauthors included Eva G. Álvarez, Adrian Baez-Ortega, Young Seok Ju, Yilong Li, and Ana Dueso-Barroso, each collaborating on multiple publications.

Publications were often featured in journals such as Nature Genetics, UNC Libraries, Nature Biotechnology, PLoS Genetics, and the Proceedings of the National Academy of Sciences. Nature Genetics was among the most frequent venues.

  • Nature Genetics
  • UNC Libraries
  • Nature Biotechnology
  • PLoS Genetics
  • Proceedings of the National Academy of Sciences

Key papers authored or coauthored by Haig H. Kazazian include:

  • "Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition" (2020, Nature Genetics)
  • "A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells" (2020, Nature Biotechnology)
  • "Striking heterogeneity of somatic L1 retrotransposition in single normal and cancerous gastrointestinal cells" (2020, Proceedings of the National Academy of Sciences)
  • "ZCCHC3 is a stress granule zinc knuckle protein that strongly suppresses LINE-1 retrotransposition" (2023, PLoS Genetics)
  • "Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition" (2023, Nature Genetics)

Their contributions to the field were recognized with awards including the William Allan Award from the American Society of Human Genetics in 2008 and election as a Fellow of the American Academy of Arts and Sciences in 2007.

Best Publications

  • Mobile elements: drivers of genome evolution.

    Haig H. Kazazian

  • Human L1 Retrotransposon Encodes a Conserved Endonuclease Required for Retrotransposition

    Qinghua Feng;John V. Moran;Haig H. Kazazian;Jef D. Boeke

  • High Frequency Retrotransposition in Cultured Mammalian Cells

    John V. Moran;Susan E. Holmes;Thierry P. Naas;Ralph J. DeBerardinis

  • Hot L1s account for the bulk of retrotransposition in the human population

    Brook Brouha;Joshua Schustak;Richard M. Badge;Richard M. Badge;Sheila Lutz-Prigge

  • Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster

    Stuart H. Orkin;Haig H. Kazazian;Stylianos E. Antonarakis;Sabra C. Goff

  • Inversions disrupting the factor VIII gene are a common cause of severe haemophilia A.

    Delia Lakich;Haig H. Kazazian;Stylianos E. Antonarakis;Stylianos E. Antonarakis;Jane Gitschier

  • Biology of Mammalian L1 Retrotransposons

    Eric M. Ostertag;Haig H. Kazazian

  • Haemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man.

    Haig H. Kazazian;Corinne Wong;Hagop Youssoufian;Hagop Youssoufian;Alan F. Scott

  • Human L1 retrotransposition: cis preference versus trans complementation.

    Wei Wei;Nicolas Gilbert;Siew Loon Ooi;Joseph F. Lawler

  • Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A

    L. Bi;A. M. Lawler;Stylianos Antonarakis;K. A. High

  • Reverse transcriptase encoded by a human transposable element.

    Stephen L. Mathias;Alan F. Scott;Haig H. Kazazian;Jef D. Boeke

  • Retrotransposons Revisited: The Restraint and Rehabilitation of Parasites

    John L. Goodier;Haig H. Kazazian

  • Exon Shuffling by L1 Retrotransposition

    John V. Moran;Ralph J. DeBerardinis;Haig H. Kazazian

  • Characterization of β-thalassaemia mutations using direct genomic sequencing of amplified single copy DNA

    Corinne Wong;Carol E. Dowling;Randall K. Saiki;Russell G. Higuchi

  • Active human retrotransposons: variation and disease.

    Dustin C. Hancks;Haig H. Kazazian

  • Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21

    Jean Louis Blouin;Beth A. Dombroski;Swapan K. Nath;Virginia K. Lasseter

  • The impact of L1 retrotransposons on the human genome.

    Haig H. Kazazian;John V. Moran

  • Roles for retrotransposon insertions in human disease

    Dustin C. Hancks;Haig H. Kazazian

  • Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina.

    G R Cutting;L Lu;B F O'Hara;L M Kasch

  • A cluster of cystic fibrosis mutations in the first nucleotide-binding fold of the cystic fibrosis conductance regulator protein.

    Garry R. Cutting;Laura M. Kasch;Beryl J. Rosenstein;Julian Zielenski

Frequent Co-Authors

Stylianos E. Antonarakis
Stylianos E. Antonarakis University of Geneva
John V. Moran
John V. Moran University of Michigan–Ann Arbor
Stuart H. Orkin
Stuart H. Orkin Harvard University
Gerald Nestadt
Gerald Nestadt Johns Hopkins University School of Medicine
Alan F. Scott
Alan F. Scott Johns Hopkins University
Ann E. Pulver
Ann E. Pulver Johns Hopkins University School of Medicine
Ralph J. DeBerardinis
Ralph J. DeBerardinis The University of Texas Southwestern Medical Center
John A. Phillips
John A. Phillips Vanderbilt University Medical Center
Jean-Louis Blouin
Jean-Louis Blouin University of Geneva

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