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Genetics

D-Index
64
Citations
54255
World Ranking
2728
National Ranking
1196

Research.com Recognitions

  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

John V. Moran is a researcher affiliated with the University of Michigan-Ann Arbor in the United States. Their work contributes primarily to the fields of Biochemistry, Genetics, and Molecular Biology, with additional research in Agricultural and Biological Sciences.

Their scientific focus includes several subfields such as Molecular Biology, Genetics, Plant Science, Cancer Research, and Immunology. Moran's research topics cover areas like Chromosomal and Genetic Variations, CRISPR and Genetic Engineering, Genomic Variations and Chromosomal Abnormalities, Genomics and Rare Diseases, Cancer Genomics and Diagnostics, RNA and Protein Synthesis Mechanisms, and Genomics and Phylogenetic Studies.

Frequent co-authors collaborating with Moran include Yanmei Dou, Jeffrey M. Kidd, Alexej Abyzov, John B. Moldovan, and Maxwell A. Sherman.

The scientist's recent publications demonstrate a range of investigations in genomic sciences and neuroscience. Notable papers include:

  • The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing (2021, Nature Neuroscience)
  • Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability (2022, Science)
  • Long-read assembly of a Great Dane genome highlights the contribution of GC-rich sequence and mobile elements to canine genomes (2021, Proceedings of the National Academy of Sciences)
  • Comprehensive identification of somatic nucleotide variants in human brain tissue (2021, Genome Biology)
  • Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia (2021, Nature Neuroscience)

Moran's work appears regularly in several key publication venues, with multiple publications in bioRxiv (Cold Spring Harbor Laboratory), Nature Neuroscience, Nature Communications, Nucleic Acids Research, and Science.

In recognition of their contributions to science, Moran was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2012.

Best Publications

  • Initial sequencing and analysis of the human genome.

    Eric S. Lander;Lauren M. Linton;Bruce Birren;Chad Nusbaum

  • Human L1 Retrotransposon Encodes a Conserved Endonuclease Required for Retrotransposition

    Qinghua Feng;John V. Moran;Haig H. Kazazian;Jef D. Boeke

  • High Frequency Retrotransposition in Cultured Mammalian Cells

    John V. Moran;Susan E. Holmes;Thierry P. Naas;Ralph J. DeBerardinis

  • Hot L1s account for the bulk of retrotransposition in the human population

    Brook Brouha;Joshua Schustak;Richard M. Badge;Richard M. Badge;Sheila Lutz-Prigge

  • Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition

    Alysson R. Muotri;Vi T. Chu;Maria C. N. Marchetto;Wei Deng

  • L1 Retrotransposition in Human Neural Progenitor Cells

    Nicole G. Coufal;José L. Garcia-Perez;José L. Garcia-Perez;Grace E. Peng;Gene W. Yeo;Gene W. Yeo

  • Human L1 retrotransposition: cis preference versus trans complementation.

    Wei Wei;Nicolas Gilbert;Siew Loon Ooi;Joseph F. Lawler

  • LINE-1 Retrotransposition Activity in Human Genomes

    Christine R. Beck;Pamela Collier;Catriona Macfarlane;Maika Malig

  • Exon Shuffling by L1 Retrotransposition

    John V. Moran;Ralph J. DeBerardinis;Haig H. Kazazian

  • Dynamic interactions between transposable elements and their hosts

    Henry L. Levin;John V. Moran

  • The impact of L1 retrotransposons on the human genome.

    Haig H. Kazazian;John V. Moran

  • LINE-1 Elements in Structural Variation and Disease

    Christine R. Beck;José Luis Garcia-Perez;Richard M. Badge;John V. Moran

  • Mobile elements and mammalian genome evolution

    Prescott L Deininger;John V Moran;Mark A Batzer;Haig H Kazazian

  • Many human L1 elements are capable of retrotransposition.

    Donna M. Sassaman;Beth A. Dombroski;John V. Moran;Michelle L. Kimberland

  • Genomic Deletions Created upon LINE-1 Retrotransposition

    Nicolas Gilbert;Sheila Lutz-Prigge;John V. Moran

  • DNA repair mediated by endonuclease-independent LINE-1 retrotransposition

    Tammy A. Morrish;Nicolas Gilbert;Jeremy S. Myers;Bethaney J. Vincent

  • Research capacity. Enabling the genomic revolution in Africa

    Charles Rotimi;Akin Abayomi;Alash'le Abimiku;Victoria May Adabayeri

  • Mobile DNA in Health and Disease.

    Haig H. Kazazian;John V. Moran

  • Cellular inhibitors of long interspersed element 1 and Alu retrotransposition.

    Hal P. Bogerd;Heather L. Wiegand;Amy E. Hulme;José L. Garcia-Perez

  • Cis-preferential LINE-1 reverse transcriptase activity in ribonucleoprotein particles.

    Deanna A Kulpa;John V Moran

Frequent Co-Authors

Jose L. Garcia-Perez
Jose L. Garcia-Perez University of Granada
Haig H. Kazazian
Haig H. Kazazian Johns Hopkins University School of Medicine
Jeffrey M. Kidd
Jeffrey M. Kidd University of Michigan–Ann Arbor
Mark A. Batzer
Mark A. Batzer Louisiana State University
Flora M. Vaccarino
Flora M. Vaccarino Yale University
Fred H. Gage
Fred H. Gage Salk Institute for Biological Studies
Ralph J. DeBerardinis
Ralph J. DeBerardinis The University of Texas Southwestern Medical Center
Jonathan Pevsner
Jonathan Pevsner National Institute of Mental Health
Joseph G. Gleeson
Joseph G. Gleeson University of California, San Diego
Alexej Abyzov
Alexej Abyzov Mayo Clinic

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