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Biology and Biochemistry

D-Index
68
Citations
11705
World Ranking
8004
National Ranking
278

Overview

Murray W. Huff is affiliated with the University of Western Ontario in Canada. Their research primarily intersects the fields of medicine and biochemistry, genetics, and molecular biology, with a focus on understanding mechanisms related to lipid metabolism and cardiovascular health.

Their work addresses several main topics, including:

  • Cholesterol and Lipid Metabolism
  • Bioactive Compounds in Plants
  • Phytochemicals and Antioxidant Activities
  • Bioactive natural compounds
  • Atherosclerosis and Cardiovascular Diseases
  • Lipid metabolism and disorders
  • Nitric Oxide and Endothelin Effects

Huff's scholarly output includes contributions to surgery, molecular biology, cardiology and cardiovascular medicine, plant science, and biochemistry as subfields of study.

Their recent publications include:

  • The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK, 2020, Journal of Lipid Research
  • Activity of Inwardly Rectifying K + Channels in Cerebral Arteries is Diminished in Dyslipidemia Without Overt Effects on Cerebral Blood Flow, 2021, The FASEB Journal
  • From Cells-to-Organism: Impact of Dyslipidemia on Inwardly Rectifying K + Channels and Cerebral Vascular Function, 2020, The FASEB Journal

Frequent coauthors in their research include:

  • Katey J. Rayner
  • Paulina M. Kowalewska
  • María Sancho
  • Sergio Fabris
  • Robert Gros

Their research has been published notably in the following venues:

  • The FASEB Journal
  • Journal of Lipid Research

Best Publications

  • Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia

    Christopher T Johansen;Jian Wang;Matthew B Lanktree;Henian Cao

  • Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP

    Lisa J. Wilcox;Nica M. Borradaile;Linda E. de Dreu;Murray W. Huff

  • Naringenin Prevents Dyslipidemia, Apolipoprotein B Overproduction, and Hyperinsulinemia in LDL Receptor–Null Mice With Diet-Induced Insulin Resistance

    Erin E. Mulvihill;Emma M. Allister;Emma M. Allister;Brian G. Sutherland;Dawn E. Telford

  • Effects of dietary protein on turnover, oxidation, and absorption of cholesterol, and on steroid excretion in rabbits.

    M W Huff;K K Carroll

  • Citrus flavonoids and lipid metabolism.

    Julia M. Assini;Erin E. Mulvihill;Murray W. Huff

  • Hypocholesterolemic effect of substituting soybean protein for animal protein in the diet of healthy young women.

    K K Carroll;P M Giovannetti;M W Huff;O Moase

  • Antiatherogenic properties of flavonoids: Implications for cardiovascular health

    Erin E. Mulvihill;Murray W. Huff;Murray W. Huff

  • Citrus Flavonoids as Regulators of Lipoprotein Metabolism and Atherosclerosis

    Erin E. Mulvihill;Amy C. Burke;Murray W. Huff

  • Polygenic Versus Monogenic Causes of Hypercholesterolemia Ascertained Clinically.

    Jian Wang;Jacqueline S. Dron;Matthew R. Ban;John F. Robinson

  • Antiatherogenic Properties of Naringenin, a Citrus Flavonoid

    Lisa J. Wilcox;Nica M. Borradaile;Murray W. Huff

  • Inhibition of Net HepG2 Cell Apolipoprotein B Secretion by the Citrus Flavonoid Naringenin Involves Activation of Phosphatidylinositol 3-Kinase, Independent of Insulin Receptor Substrate-1 Phosphorylation

    Nica M. Borradaile;Linda E. de Dreu;Murray W. Huff

  • Naringenin Decreases Progression of Atherosclerosis by Improving Dyslipidemia in High-Fat–Fed Low-Density Lipoprotein Receptor–Null Mice

    Erin E. Mulvihill;Julia M. Assini;Brian G. Sutherland;Alessandra S. DiMattia

  • Effects of dietary proteins and amino acid mixtures on plasma cholesterol levels in rabbits.

    Murray W. Huff;Kenneth K. Carroll

  • Soya phytoestrogens, genistein and daidzein, decrease apolipoprotein B secretion from HepG2 cells through multiple mechanisms

    Nica M Borradaile;Nica M Borradaile;Linda E de Dreu;Lisa J Wilcox;Lisa J Wilcox;Jane Y Edwards;Jane Y Edwards

  • Flaxseed: A potential treatment for lupus nephritis

    William F. Clark;William F. Clark;Anwar Parbtani;Anwar Parbtani;Murray W. Huff;Murray W. Huff;Evelyn Spanner;Evelyn Spanner

  • Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux.

    Carmen A. Argmann;Carmen A. Argmann;Jane Y. Edwards;Cynthia G. Sawyez;Caroline H. O'Neil

  • Naringenin prevents cholesterol-induced systemic inflammation, metabolic dysregulation and atherosclerosis in Ldlr-/- mice.

    Julia M. Assini;Erin E. Mulvihill;Brian G. Sutherland;Dawn E. Telford

  • Inhibition of Microsomal Triglyceride Transfer Protein Expression and Apolipoprotein B100 Secretion by the Citrus Flavonoid Naringenin and by Insulin Involves Activation of the Mitogen-Activated Protein Kinase Pathway in Hepatocytes

    Emma M. Allister;Nica M. Borradaile;Jane Y. Edwards;Murray W. Huff

  • Polygenic determinants of severe hypertriglyceridemia

    Jian Wang;Matthew R. Ban;Guang Yong Zou;Henian Cao

  • 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and hepatic apolipoprotein B secretion

    Murray W. Huff;John R. Burnett

Frequent Co-Authors

Robert A. Hegele
Robert A. Hegele University of Western Ontario
Philip W. Connelly
Philip W. Connelly University of Toronto
Sonia S. Anand
Sonia S. Anand McMaster University
Salim Yusuf
Salim Yusuf McMaster University
Paul J. Nestel
Paul J. Nestel Baker IDI Heart and Diabetes Institute
Anthony J.G. Hanley
Anthony J.G. Hanley University of Toronto
Sekar Kathiresan
Sekar Kathiresan Harvard University
Gregory R. Steinberg
Gregory R. Steinberg McMaster University
Benjamin F. Voight
Benjamin F. Voight University of Pennsylvania
Alexei Kharitonenkov
Alexei Kharitonenkov Indiana University

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