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Jean-Charles Fruchart

Jean-Charles Fruchart

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Medicine
France
2023

D-Index & Metrics

Medicine

D-Index
147
Citations
80827
World Ranking
1285
National Ranking
29

Research.com Recognitions

  • 2023 - Research.com Medicine in France Leader Award

Overview

Jean-Charles Fruchart is affiliated with the Institut Pasteur in France and has contributed extensively to research in medicine, particularly focusing on the areas of metabolism and cardiovascular health. Their work spans several subfields including molecular biology, endocrinology, diabetes and metabolism, surgery, epidemiology, and cardiology.

The primary topics of Jean-Charles Fruchart's research involve peroxisome proliferator-activated receptors, liver disease diagnosis and treatment, diabetes treatment and management, as well as diabetes-related cardiovascular risks and lipoproteins. Their investigations also cover fatty acid research and health, cholesterol and lipid metabolism, and endoplasmic reticulum stress and its role in disease.

Key recent publications by Jean-Charles Fruchart include:

  • Lessons from PROMINENT and prospects for pemafibrate, 2024, Cardiovascular Diabetology
  • Selective PPARα Modulator Pemafibrate and Sodium-Glucose Cotransporter 2 Inhibitor Tofogliflozin Combination Treatment Improved Histopathology in Experimental Mice Model of Non-Alcoholic Steatohepatitis, 2022, Cells
  • Selective Peroxisome Proliferator-Activated Receptor Alpha Modulators (SPPARMα) in the Metabolic Syndrome: Is Pemafibrate Light at the End of the Tunnel?, 2021, Current Atherosclerosis Reports
  • Selective Peroxisome Proliferator-Activated Receptor Alpha Modulators (SPPARMα): New Opportunities to Reduce Residual Cardiovascular Risk in Chronic Kidney Disease?, 2020, Current Atherosclerosis Reports

Another notable paper co-authored by Jean-Charles Fruchart is Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk, published in 2022 in the New England Journal of Medicine.

Jean-Charles Fruchart collaborates frequently with several researchers, including Tatsuhiko Kodama, Jamila Fruchart-Najib, Michel P. Hermans, Koutaro Yokote, and Peter Libby. These collaborations reflect a consistent engagement within a network of experts focused on related biomedical topics.

The scientist's research outputs are published across journals frequently including Current Atherosclerosis Reports, New England Journal of Medicine, Cells, and Cardiovascular Diabetology. This range illustrates a focus on cardiovascular and metabolic disorders at both clinical and molecular levels.

Best Publications

  • Mechanism of Action of Fibrates on Lipid and Lipoprotein Metabolism

    Bart Staels;Jean Dallongeville;Johan Auwerx;Kristina Schoonjans

  • HDL Cholesterol, Very Low Levels of LDL Cholesterol, and Cardiovascular Events

    Philip Barter;Antonio M. Gotto;John C. LaRosa;Jaman Maroni

  • The organization, promoter analysis, and expression of the human PPARgamma gene.

    Lluis Fajas;Didier Auboeuf;Eric Raspé;Kristina Schoonjans

  • Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators

    Bart Staels;Wolfgang Koenig;Aïda Habib;Régine Merval

  • PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway.

    Chinetti G;Lestavel S;Bocher;Remaley At

  • Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

    Philippe Delerive;Karolien De Bosscher;Sandrine Besnard;Wim Vanden Berghe

  • An Apolipoprotein Influencing Triglycerides in Humans and Mice Revealed by Comparative Sequencing

    Len A. Pennacchio;Michael Olivier;Jaroslav A. Hubacek;Jonathan C. Cohen

  • Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages.

    Giulia Chinetti;Sabine Griglio;Micheline Antonucci;Inés Pineda Torra

  • Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity

    Robert Ross;Ian J. Neeland;Shizuya Yamashita;Iris Shai

  • Sorting out the roles of PPARα in energy metabolism and vascular homeostasis

    Philippe Lefebvre;Giulia Chinetti;Jean-Charles Fruchart;Bart Staels

  • Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement

    Ian J. Neeland;Robert Ross;Jean Pierre Després;Yuji Matsuzawa

  • Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity

    Michèle Guerre-Millo;Philippe Gervois;Eric Raspé;Lise Madsen

  • Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice.

    Anne-Marie Lefebvre;Inhua Chen;Pierre Desreumaux;Jamila Najib

  • Therapeutic Roles of Peroxisome Proliferator–Activated Receptor Agonists

    Bart Staels;Jean Charles Fruchart

  • Peroxisome proliferator-activated receptors in inflammation control.

    P Delerive;JC Fruchart;B Staels

  • Measurement of Arterial Wall Thickness as a Surrogate Marker for Atherosclerosis

    Eric de Groot;G. Kees Hovingh;Albert Wiegman;Patrick Duriez

  • Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway

    Philippe Delerive;Françoise Martin-Nizard;Giulia Chinetti;François Trottein

  • Effect of lowering LDL cholesterol substantially below currently recommended levels in patients with coronary heart disease and diabetes: the Treating to New Targets (TNT) study.

    James Shepherd;Philip Barter;Rafael Carmena;Prakash Deedwania

  • Intensive Lipid Lowering With Atorvastatin in Patients With Stable Coronary Disease

    J.C. LaRosa;S.M. Grundy;D.D. Waters

  • Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation

    Virginie Bocher;Giulia Chinetti;Jean-Charles Fruchart;Bart Staels

Frequent Co-Authors

Bart Staels
Bart Staels University of Lille
Catherine Fievet
Catherine Fievet Institut Pasteur
Jean Dallongeville
Jean Dallongeville Institut Pasteur
Johan Auwerx
Johan Auwerx École Polytechnique Fédérale de Lausanne
Gérard Torpier
Gérard Torpier Institut Pasteur
Folkert Kuipers
Folkert Kuipers University Medical Center Groningen
Len A. Pennacchio
Len A. Pennacchio Lawrence Berkeley National Laboratory
Bertrand Cariou
Bertrand Cariou University of Nantes
Roméo Cecchelli
Roméo Cecchelli Artois University
Dominique Arveiler
Dominique Arveiler University of Strasbourg

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