2026 J. David Spence: Medicine Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Medicine	99	8441	7932	327	311	635	49451

Overview

J. David Spence is affiliated with the University of Western Ontario in Canada, with a primary research focus within the field of Medicine.

Their work is concentrated particularly in several subfields, including:

Cardiology and Cardiovascular Medicine
Pulmonary and Respiratory Medicine
Surgery
Rheumatology
Public Health, Environmental and Occupational Health

Spence's main research topics encompass:

Cerebrovascular and Carotid Artery Diseases
Cardiovascular Health and Disease Prevention
Blood Pressure and Hypertension Studies
Folate and B Vitamins Research
Nutritional Studies and Diet
Lipoproteins and Cardiovascular Health
Acute Ischemic Stroke Management

The scientist has published extensively in various venues, with frequent publications in:

Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
Atherosclerosis
Stroke
Ultrasound in Medicine & Biology
Hypertension

Some recent papers authored by Spence include:

"Mechanisms of Stroke in COVID-19" (2020), published in Cerebrovascular Diseases
"Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment" (2021), published in Journal of the American College of Cardiology (note: this paper's primary author is David J.A. Jenkins, but it is included among related recent works)
"Interaction of serum vitamin B ₁₂ and folate with MTHFR genotypes on risk of ischemic stroke" (2020), published in Neurology (authored by Xianhui Qin)
"Deep Learning-Based Measurement of Total Plaque Area in B-Mode Ultrasound Images" (2021), published in IEEE Journal of Biomedical and Health Informatics (authored by Ran Zhou)
"A Voxel-Based Fully Convolution Network and Continuous Max-Flow for Carotid Vessel-Wall-Volume Segmentation From 3D Ultrasound Images" (2020), published in IEEE Transactions on Medical Imaging (authored by Ran Zhou)

Frequent co-authors collaborating with Spence include:

Mahmoud Reza Azarpazhooh
Yong Huo
Xiao Huang
Graeme J. Hankey
Xiaoshu Cheng

Best Publications

Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators.

H J Barnett;D W Taylor;M Eliasziw;A J Fox

5235
Citations
Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial.

James F. Toole;M. René Malinow;Lloyd E. Chambless;J. David Spence

1968
Citations
Atrial Fibrillation in Patients with Cryptogenic Stroke

David J. Gladstone;Melanie Spring;Paul Dorian;Val Panzov

1373
Citations
Pioglitazone after Ischemic Stroke or Transient Ischemic Attack

W. N. Kernan;C. M. Viscoli;K. L. Furie;L. H. Young

1202
Citations
Pharmacokinetic-Pharmacodynamic Consequences and Clinical Relevance of Cytochrome P450 3A4 Inhibition

G K Dresser;J D Spence;D G Bailey

1179
Citations
Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke

Lars Søndergaard;Scott E. Kasner;John F. Rhodes;Grethe Andersen

1061
Citations
Grapefruit juice–drug interactions

David G. Bailey;J. Malcolm;O. Arnold;J. David Spence

1009
Citations
Interaction of citrus juices with felodipine and nifedipine.

D. G. Bailey;J. D. Spence;C. Munoz;J. M. O. Arnold

821
Citations
Carotid Plaque Area A Tool for Targeting and Evaluating Vascular Preventive Therapy

J. David Spence;Michael Eliasziw;Maria DiCicco;Daniel G. Hackam

743
Citations
Carotid endarterectomy—an evidence-based review: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology

S. Chaturvedi;A. Bruno;T. Feasby;R. Holloway

704
Citations
Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals.

R Clarke;J Halsey;S Lewington;E Lonn

667
Citations
Low-dose and high-dose acetylsalicylic acid for patients undergoing carotid endarterectomy: a randomised controlled trial

D Wayne Taylor;Henry Jm Barnett;R Brian Haynes;Gary G Ferguson

652
Citations
Psychological stress and the progression of carotid artery disease.

Peter Barnett;J Spence;Stephen Manuck;J Jennings

541
Citations
Combining multiple approaches for the secondary prevention of vascular events after stroke: a quantitative modeling study.

Daniel G. Hackam;J. David Spence

525
Citations
Effects of intensive medical therapy on microemboli and cardiovascular risk in asymptomatic carotid stenosis.

J. David Spence;Victoria Coates;Hector Li;Arturo Tamayo

434
Citations
Geometry of the Carotid Bifurcation Predicts Its Exposure to Disturbed Flow

Sang-Wook Lee;Luca Antiga;J. David Spence;David A. Steinman

432
Citations
HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia

Elzbieta M Kurowska;J David Spence;John Jordan;Stephen Wetmore

415
Citations
Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: Meta-analyses of data on 50 000 individuals

Stein Emil Vollset;Robert Clarke;Sarah Lewington;Marta Ebbing

403
Citations
Socioeconomic status and stroke incidence, prevalence, mortality, and worldwide burden: an ecological analysis from the Global Burden of Disease Study 2017

Abolfazl Avan;Hadi Digaleh;Mario Di Napoli;Saverio Stranges

383
Citations
Effect of B-Vitamin Therapy on Progression of Diabetic Nephropathy: A Randomized Controlled Trial

Andrew A. House;Misha Eliasziw;Daniel C. Cattran;David N. Churchill

350
Citations

Frequent Co-Authors

Aaron Fenster University of Western Ontario

Robert A. Hegele University of Western Ontario

Vladimir Hachinski University of Western Ontario

Rob S. Beanlands University of Ottawa

Jean-Claude Tardif Montreal Heart Institute

Meir J. Stampfer Harvard University

David J.A. Jenkins University of Toronto

Stewart B. Harris University of Western Ontario

Anthony J.G. Hanley University of Toronto

Graeme J. Hankey University of Western Australia

External Links

Personal website of J. David Spence

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