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2025
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2026

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Best Scientists

D-Index
254
Citations
262130
World Ranking
45
National Ranking
29

Neuroscience

D-Index
258
Citations
268906
World Ranking
6
National Ranking
4

Medicine

D-Index
257
Citations
268442
World Ranking
31
National Ranking
22

Research.com Recognitions

  • 2026 - Research.com Medicine in United States Leader Award
  • 2026 - Research.com Neuroscience in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Medicine in United States Leader Award
  • 2025 - Research.com Neuroscience in United States Leader Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • 2022 - Research.com Neuroscience in United States Leader Award
  • 2013 - Fellow, National Academy of Inventors
  • 2008 - Keio Medical Science Prize, Keio University, Tokyo, Japan
  • 2005 - Fellow of the American Academy of Arts and Sciences
  • 2003 - Member of the National Academy of Sciences
  • 2001 - Metlife Foundation Award for Medical Research in Alzheimer's Disease
  • 2001 - Member of the National Academy of Medicine (NAM)
  • 1998 - Robert J. and Claire Pasarow Foundation Medical Research Award
  • 1996 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Fred H. Gage is affiliated with the Salk Institute for Biological Studies in the United States. Their research spans several interconnected fields including biochemistry, genetics and molecular biology, neuroscience, and medicine. Within these broader domains, their work focuses more specifically on molecular biology, cellular and molecular neuroscience, genetics, neurology, and developmental neuroscience.

The main topics of their research include:

  • Neurogenesis and neuroplasticity mechanisms
  • Neuroinflammation and neurodegeneration mechanisms
  • Genetics and neurodevelopmental disorders
  • Bipolar disorder and treatment
  • Pluripotent stem cells research
  • Neuroscience and neuropharmacology research
  • CRISPR and genetic engineering

Fred H. Gage has contributed research published in various venues, with the most frequent publication platforms being bioRxiv (Cold Spring Harbor Laboratory), Molecular Psychiatry, Science, Biological Psychiatry, and Proceedings of the National Academy of Sciences.

Their coauthors frequently include:

  • Sara B. Linker
  • Simon T. Schafer
  • Shani Stern
  • Yanmei Dou
  • Maria C. Marchetto

Some recent research papers include:

  • "The role of retrotransposable elements in ageing and age-associated diseases," 2021, published in Nature
  • "A nomenclature consensus for nervous system organoids and assembloids," 2022, published in Nature
  • "Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients," 2021, published in Cell Stem Cell
  • "An in vivo neuroimmune organoid model to study human microglia phenotypes," 2023, published in Cell
  • "Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis," 2020, published in Cell Stem Cell

The scientist has been recognized with several awards throughout their career, including:

  • Fellow, National Academy of Inventors (2013)
  • Keio Medical Science Prize, Keio University, Tokyo, Japan (2008)
  • Fellow of the American Academy of Arts and Sciences (2005)
  • Member of the National Academy of Sciences (2003)
  • Metlife Foundation Award for Medical Research in Alzheimer's Disease (2001)
  • Member of the National Academy of Medicine (NAM) (2001)
  • Robert J. and Claire Pasarow Foundation Medical Research Award (1998)
  • Fellow of the American Association for the Advancement of Science (AAAS) (1996)

Best Publications

  • Neurogenesis in the adult human hippocampus

    Peter S. Eriksson;Ekaterina Perfilieva;Thomas Björk-Eriksson;Ann Marie Alborn

  • Mammalian neural stem cells.

    Fred H. Gage

  • In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

    Luigi Naldini;Ulrike Blömer;Philippe Gallay;Daniel Ory

  • Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus.

    Henriette van Praag;Gerd Kempermann;Gerd Kempermann;Fred H. Gage

  • More hippocampal neurons in adult mice living in an enriched environment

    Kempermann G;Kuhn Hg;Gage Fh

  • Mechanisms underlying inflammation in neurodegeneration.

    Christopher K. Glass;Kaoru Saijo;Beate Winner;Maria Carolina Marchetto

  • Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation

    HG Kuhn;H Dickinson-Anson;FH Gage

  • Running enhances neurogenesis, learning, and long-term potentiation in mice

    H M van Praag;B R Christie;T J Sejnowski;F H Gage

  • Mechanisms and functional implications of adult neurogenesis.

    Chunmei Zhao;Wei Deng;Fred H. Gage

  • Functional neurogenesis in the adult hippocampus

    Henriette van Praag;Alejandro F. Schinder;Brian R. Christie;Brian R. Christie;Nicolas Toni

  • Neural consequences of environmental enrichment.

    Henriette van Praag;Gerd Kempermann;Fred H. Gage

  • Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice

    Henriette van Praag;Tiffany Shubert;Chunmei Zhao;Fred H. Gage

  • New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

    Wei Deng;James B. Aimone;Fred H. Gage

  • Direct isolation of human central nervous system stem cells

    Nobuko Uchida;David W. Buck;Dongping He;Michael J. Reitsma

  • Vascular niche for adult hippocampal neurogenesis.

    Theo D. Palmer;Andrew R. Willhoite;Fred H. Gage

  • Reactive astrocytes: cellular and molecular cues to biological function

    J.L. Ridet;A. Privat;S.K. Malhotra;F.H. Gage

  • Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector

    Luigi Naldini;Ulrike Blomer;Fred H. Gage;Didier Trono

  • Astroglia induce neurogenesis from adult neural stem cells

    Hongjun Song;Charles F. Stevens;Fred H. Gage

  • Wnt signalling regulates adult hippocampal neurogenesis

    Dieter Chichung Lie;Sophia A. Colamarino;Hong Jun Song;Hong Jun Song;Laurent Désiré

  • A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation

    C. D. Clelland;M. Choi;C. Romberg;G. D. Clemenson

Frequent Co-Authors

Anders Björklund
Anders Björklund Lund University
Alysson R. Muotri
Alysson R. Muotri University of California, San Diego
Gerd Kempermann
Gerd Kempermann German Center for Neurodegenerative Diseases
Mark H. Tuszynski
Mark H. Tuszynski University of California, San Diego
György Buzsáki
György Buzsáki New York University
Kristen J. Brennand
Kristen J. Brennand Icahn School of Medicine at Mount Sinai
Kinichi Nakashima
Kinichi Nakashima Kyushu University
Inder M. Verma
Inder M. Verma Salk Institute for Biological Studies
Sebastian Jessberger
Sebastian Jessberger University of Zurich
Leon J. Thal
Leon J. Thal University of California, San Diego

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