World's Best Scientists 2026 revealed!

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Neuroscience

D-Index
128
Citations
72649
World Ranking
296
National Ranking
179

Medicine

D-Index
128
Citations
72652
World Ranking
2676
National Ranking
1495

Research.com Recognitions

  • 2004 - Sedgwick Memorial Medal, American Public Health Association
  • 2004 - Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology

Overview

Leon J. Thal was affiliated with the University of California, San Diego in the United States. Their academic work focused primarily on Medicine and Neuroscience, with notable contributions in Cognitive Neuroscience, Psychiatry and Mental Health, Physiology, Molecular Biology, and Radiology, Nuclear Medicine, and Imaging.

The research topics covered by Leon J. Thal included:

  • Dementia and Cognitive Impairment Research
  • Functional Brain Connectivity Studies
  • Alzheimer's Disease Research and Treatments
  • Neural Dynamics and Brain Function
  • Advanced Neuroimaging Techniques and Applications
  • Bayesian Modeling and Causal Inference
  • Biomedical Text Mining and Ontologies

Leon J. Thal's publication record showed frequent contributions to several journals including GeroScience, Scientific Reports, Communications Medicine, Nature Aging, and Alzheimer's Research & Therapy.

Recent publications included:

  • Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer's Pathophysiology, 2020, Scientific Reports
  • Deep learning-based polygenic risk analysis for Alzheimer's disease prediction, 2023, Communications Medicine
  • An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer's disease, 2022, Nature Aging
  • The trend of disruption in the functional brain network topology of Alzheimer's disease, 2022, Scientific Reports
  • A novel spatiotemporal graph convolutional network framework for functional connectivity biomarkers identification of Alzheimer's disease, 2024, Alzheimer's Research & Therapy

The scientist had frequent collaborations with several coauthors, prominently including Michael W. Weiner, Zaven S. Khachaturian, Andrew J. Saykin, Laurel Beckett, and John C. Morris.

Leon J. Thal was recognized by receiving notable awards such as the Sedgwick Memorial Medal from the American Public Health Association in 2004 and the Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases by the American Academy of Neurology in 2004.

Best Publications

  • Current concepts in mild cognitive impairment.

    Ronald C. Petersen;Rachelle Doody;Alexander Kurz;Richard C. Mohs

  • A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study

    Mary Sano;Christopher Ernesto;Ronald G. Thomas;Melville R. Klauber

  • Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial.

    Sally A. Shumaker;Claudine Legault;Stephen R. Rapp;Leon Thal

  • Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment

    Ronald C. Petersen;Ronald G. Thomas;Michael Grundman;David Bennett

  • Alzheimer's Disease Neuroimaging Initiative

    Susanne G. Mueller;Michael W. Weiner;Leon J. Thal;Ronald C. Petersen

  • EPIDERMAL GROWTH FACTOR AND FIBROBLAST GROWTH FACTOR-2 HAVE DIFFERENT EFFECTS ON NEURAL PROGENITORS IN THE ADULT RAT BRAIN

    H G Kuhn;J Winkler;J Winkler;G Kempermann;L J Thal;L J Thal

  • The Alzheimer's disease neuroimaging initiative

    Susanne G. Mueller;Michael W. Weiner;Michael W. Weiner;Leon J. Thal;Ronald C. Petersen

  • Ways toward an early diagnosis in Alzheimer’s disease: The Alzheimer’s Disease Neuroimaging Initiative (ADNI)

    Susanne G. Mueller;Susanne G. Mueller;Michael W. Weiner;Michael W. Weiner;Leon J. Thal;Ronald C. Petersen

  • Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer Disease: A Randomized Controlled Trial

    R. A. Mulnard;C. W. Cotman;C. Kawas;C. H. Van Dyck

  • Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials.

    Michael Grundman;Ronald C. Petersen;Steven H. Ferris;Ronald G. Thomas

  • Effects of Rofecoxib or Naproxen vs Placebo on Alzheimer Disease Progression: A Randomized Controlled Trial

    Paul S. Aisen;Kimberly A. Schafer;Michael Grundman;Eric Pfeiffer

  • Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

    Y. Iturria-Medina;R. C. Sotero;P. J. Toussaint;J. M. Mateos-Pérez

  • A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

    Mark H Tuszynski;Mark H Tuszynski;Leon Thal;Leon Thal;Mary Pay;David P Salmon

  • The Lewy body variant of Alzheimer's disease A clinical and pathologic entity

    L. Hansen;D. Salmon;D. Galasko;E. Masliah

  • Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord

    Philip J. Horner;Ann E. Power;Gerd Kempermann;Gerd Kempermann;H. Georg Kuhn

  • Comparisons of Verbal Fluency Tasks in the Detection of Dementia of the Alzheimer Type

    Andreas U. Monsch;Mark W. Bondi;Nelson Butters;David P. Salmon

  • A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study Group.

    K. L. Davis;Leon J. Thal;E. R. Gamzu;C. S. Davis

  • Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

    Peter Seubert;Tilman Oltersdorf;Michael G. Lee;Robin Barbour

  • Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease The CERAD experience, part XV

    R. J. Ellis;John M Olichney;L. J. Thal;S. S. Mirra

  • Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease

    D. E. Kang;T. Saitoh;X. Chen;Y. Xia

  • Development of cognitive instruments for use in clinical trials of antidementia drugs: additions to the Alzheimer's Disease Assessment Scale that broaden its scope. The Alzheimer's Disease Cooperative Study.

    R C Mohs;D Knopman;R C Petersen;S H Ferris

Frequent Co-Authors

David P. Salmon
David P. Salmon University of California, San Diego
Douglas Galasko
Douglas Galasko University of California, San Diego
Jody Corey-Bloom
Jody Corey-Bloom University of California, San Diego
Fred H. Gage
Fred H. Gage Salk Institute for Biological Studies
Eliezer Masliah
Eliezer Masliah National Institutes of Health
Robert Katzman
Robert Katzman University of California, San Diego
Philip J. Langlais
Philip J. Langlais San Diego State University
Mark W. Bondi
Mark W. Bondi University of California, San Diego
Steven H. Ferris
Steven H. Ferris New York University
Ronald J. Mandel
Ronald J. Mandel University of Florida

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