Ronald J. Mandel

Overview

Best Publications

• A Third-Generation Lentivirus Vector with a Conditional Packaging System

  Tom Dull;Romain Zufferey;Michael Kelly;R. J. Mandel

  3866
  Citations

• Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo.

  Romain Zufferey;Dea Nagy;Ron J. Mandel;Luigi Naldini

  2491
  Citations

• Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery

  Romain Zufferey;Thomas Dull;Ronald J. Mandel;Anatoly Bukovsky

  2398
  Citations

• Nucleus basalis and thalamic control of neocortical activity in the freely moving rat

  G Buzsaki;RG Bickford;G Ponomareff;LJ Thal

  1123
  Citations

• Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system.

  Corinna Burger;Oleg S. Gorbatyuk;Margaret J. Velardo;Carmen S. Peden

  1081
  Citations

• Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

  Deniz Kirik;Carl Rosenblad;Corinna Burger;Cecilia Lundberg

  868
  Citations

• Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system.

  Deniz Kirik;Carl Rosenblad;Anders Björklund;Ronald J. Mandel

  629
  Citations

• Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson’s disease in rats

  R. J. Mandel;S. K. Spratt;R. O. Snyder;S. E. Leff

  508
  Citations

• Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model.

  Anders Björklund;Deniz Kirik;C Rosenblad;B Georgievska

  506
  Citations

• Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease.

  Deniz Kirik;Lucy E. Annett;Corinna Burger;Nicholas Muzyczka

  475
  Citations

• Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data

  Hon-Chung Fung;Hon-Chung Fung;Hon-Chung Fung;Sonja Scholz;Mar Matarin;Javier Simón-Sánchez;Javier Simón-Sánchez

  456
  Citations

• The phosphorylation state of Ser-129 in human α-synuclein determines neurodegeneration in a rat model of Parkinson disease

  Oleg S. Gorbatyuk;Shoudong Li;Layla F. Sullivan;Weijun Chen

  372
  Citations

• Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease

  Andisheh Eslamboli;Biljana Georgievska;Rosalind M. Ridley;Harry F. Baker

  349
  Citations

• Characterization of Intrastriatal Recombinant Adeno-Associated Virus-Mediated Gene Transfer of Human Tyrosine Hydroxylase and Human GTP-Cyclohydrolase I in a Rat Model of Parkinson’s Disease

  R. J. Mandel;K. G. Rendahl;S. K. Spratt;R. O. Snyder

  340
  Citations

• Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice.

  Edgardo Rodriguez-Lebron;Eileen M. Denovan-Wright;Kevin Nash;Alfred S. Lewin

  325
  Citations

• Regional differences in the regulation of dopamine and noradrenaline release in medial frontal cortex, nucleus accumbens and caudate-putamen: a microdialysis study in the rat.

  M. Angela Cenci;Peter Kalén;Ronald J. Mandel;Anders Björklund

  321
  Citations

• Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain.

  Andisheh Eslamboli;Marina Romero-Ramos;Corinna Burger;Tomas Bjorklund

  273
  Citations

• Analysis of the PINK1 Gene in a Large Cohort of Cases With Parkinson Disease

  Ekaterina Rogaeva;Janel Johnson;Anthony E. Lang;Cindy Gulick

  258
  Citations

• Circulating Anti-Wild-Type Adeno-Associated Virus Type 2 (AAV2) Antibodies Inhibit Recombinant AAV2 (rAAV2)-Mediated, but Not rAAV5-Mediated, Gene Transfer in the Brain

  Carmen S. Peden;Corinna Burger;Nicholas Muzyczka;Ronald J. Mandel

  249
  Citations

• In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration

  Oleg S Gorbatyuk;Shoudong Li;Kevin Nash;Marina Gorbatyuk

  241
  Citations

• Immune Responses to Adenovirus and Adeno-Associated Vectors Used for Gene Therapy of Brain Diseases: The Role of Immunological Synapses in Understanding the Cell Biology of Neuroimmune Interactions

  Pedro R. Lowenstein;Ronald J. Mandel;Wei Dong Xiong;Kurt Kroeger

  223
  Citations

• Regulation of gene expression in vivo following transduction by two separate rAAV vectors

  K. G. Rendahl;S. E. Leff;G. R. Otten;S. K. Spratt

  202
  Citations

• Suppression of insult-induced neurogenesis in adult rat brain by brain-derived neurotrophic factor.

  Elin Larsson;Ronald J Mandel;Ronald L Klein;Nicholas Muzyczka

  185
  Citations