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D-Index & Metrics

Biology and Biochemistry

D-Index
100
Citations
33710
World Ranking
1533
National Ranking
862

Medicine

D-Index
101
Citations
34081
World Ranking
8045
National Ranking
4177

Overview

Donald B. Kohn is affiliated with the University of California, Los Angeles in the United States. Their research focuses primarily on medicine and biochemistry, genetics, and molecular biology, with a strong emphasis on genetics, molecular biology, immunology, oncology, and epidemiology as subfields of study.

The main research topics associated with their work include virus-based gene therapy research, CAR-T cell therapy research, immunodeficiency and autoimmune disorders, CRISPR and genetic engineering, RNA interference and gene delivery, hematopoietic stem cell transplantation, and cytomegalovirus and herpesvirus research.

Their recent notable papers are:

  • Lentiviral gene therapy for X-linked chronic granulomatous disease, 2020, published in Nature Medicine
  • Autologous Ex Vivo Lentiviral Gene Therapy for Adenosine Deaminase Deficiency, 2021, published in New England Journal of Medicine
  • Successes and challenges in clinical gene therapy, 2023, published in Gene Therapy

Frequent co-authors of Donald B. Kohn include:

  • Christopher C. Dvorak
  • Sung-Yun Pai
  • Jennifer M. Puck
  • Élie Haddad
  • Luigi D. Notarangelo

Throughout their career, Donald B. Kohn has published extensively in several scientific journals. The most frequent publication venues include Blood, Transplantation and Cellular Therapy, Journal of Allergy and Clinical Immunology, Molecular Therapy - Methods & Clinical Development, and bioRxiv (Cold Spring Harbor Laboratory).

Best Publications

  • Gene therapy comes of age.

    Cynthia E. Dunbar;Katherine A. High;J. Keith Joung;Donald B. Kohn

  • Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

    Nathalia Holt;Jianbin Wang;Kenneth Kim;Geoffrey Friedman

  • Transplantation Outcomes for Severe Combined Immunodeficiency, 2000–2009

    Sung Yun Pai;Brent R. Logan;Linda M. Griffith;Rebecca H. Buckley

  • Newborn Screening for Severe Combined Immunodeficiency in 11 Screening Programs in the United States

    Antonia Kwan;Roshini S. Abraham;Robert Currier;Amy Brower

  • Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency.

    D B Kohn;K I Weinberg;J A Nolta;L N Heiss

  • Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo.

    Pia-Maria Challita;Donald B. Kohn

  • Stable transduction of quiescent CD34+CD38− human hematopoietic cells by HIV-1-based lentiviral vectors

    Scott S. Case;Mary A. Price;Craig T. Jordan;Xiao Jin Yu

  • Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells.

    Mark A. DeWitt;Wendy Magis;Nicolas L. Bray;Tianjiao Wang

  • Occurrence of leukaemia following gene therapy of X-linked SCID.

    Donald B. Kohn;Michel Sadelain;Joseph C. Glorioso

  • A Modified γ-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency

    Salima Hacein-Bey-Abina;Sung Yun Pai;H. Bobby Gaspar;Myriam Armant

  • Analyzing CRISPR genome-editing experiments with CRISPResso

    Pinello L;Canver Mc;Hoban;Orkin Sh

  • A Single CRISPR-Cas9 Deletion Strategy that Targets the Majority of DMD Patients Restores Dystrophin Function in hiPSC-Derived Muscle Cells

    Courtney S. Young;Michael R. Hicks;Natalia V. Ermolova;Haruko Nakano

  • Immune response to green fluorescent protein: implications for gene therapy

    R. Stripecke;R. Stripecke;M. Del Carmen Villacres;D. C. Skelton;Noriko Satake

  • T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates

    Kohn Db;Hershfield Ms;Carbonaro D;Shigeoka A

  • Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells

    Megan D. Hoban;Gregory J. Cost;Matthew C. Mendel;Zulema Romero

  • A Clinical Trial of Retroviral-Mediated Transfer of arev-Responsive Element Decoy Gene Into CD34+Cells From the Bone Marrow of Human Immunodeficiency Virus-1–Infected Children

    Donald B. Kohn;Gerhard Bauer;C. Robert Rice;J. C. Rothschild

  • Establishing diagnostic criteria for severe combined immunodeficiency disease (SCID), leaky SCID, and Omenn syndrome: The Primary Immune Deficiency Treatment Consortium experience

    William T. Shearer;Elizabeth Dunn;Luigi D. Notarangelo;Christopher C. Dvorak

  • Genetic therapies against HIV

    John J Rossi;Carl H June;Donald B Kohn

  • Multiple modifications in cis elements of the long terminal repeat of retroviral vectors lead to increased expression and decreased DNA methylation in embryonic carcinoma cells.

    P.-M. Challita;D. Skelton;A. El-Khoueiry;Xiao-Jin Yu

  • Sustained Human Hematopoiesis in Immunodeficient Mice by Cotransplantation of Marrow Stroma Expressing Human Interleukin-3: Analysis of Gene Transduction of Long-Lived Progenitors

    Jan A. Nolta;Mary Beth Hanley;Donald B. Kohn

Frequent Co-Authors

Kenneth I. Weinberg
Kenneth I. Weinberg Stanford University
Robertson Parkman
Robertson Parkman University of Southern California
Jan A. Nolta
Jan A. Nolta University of California, Davis
Fabio Candotti
Fabio Candotti National Institutes of Health
Jennifer M. Puck
Jennifer M. Puck University of California, San Francisco
Morton J. Cowan
Morton J. Cowan University of California, San Francisco
Sung-Yun Pai
Sung-Yun Pai National Institutes of Health
Luigi D. Notarangelo
Luigi D. Notarangelo National Institutes of Health
Rebecca H. Buckley
Rebecca H. Buckley Duke University
Brent R. Logan
Brent R. Logan Medical College of Wisconsin

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