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Biology and Biochemistry

D-Index
62
Citations
13470
World Ranking
10822
National Ranking
389

Overview

Philippe Delagrange is affiliated with the Centre national de la recherche scientifique (CNRS) in France. Their research spans neuroscience and biochemistry, genetics, and molecular biology, with a focus on endocrine and autonomic systems, cell biology, molecular biology, cellular and molecular neuroscience, and physiology.

Their work investigates several main topics including circadian rhythm and melatonin, microtubule and mitosis dynamics, receptor mechanisms and signaling, neuroscience and neuropharmacology research, Alzheimer's disease research and treatments, free radicals and antioxidants, and cellular transport and secretion.

Delagrange has published multiple papers in notable venues, including:

  • "Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease" (2021, Brain)
  • "Pharmacological evidence for transactivation within melatonin MT 2 and serotonin 5-HT 2C receptor heteromers in mouse brain" (2020, The FASEB Journal)
  • "GPR50-Ctail cleavage and nuclear translocation: a new signal transduction mode for G protein-coupled receptors" (2020, Cellular and Molecular Life Sciences)
  • "Quinazoline and phthalazine derivatives as novel melatonin receptor ligands analogues of agomelatine" (2020, European Journal of Medicinal Chemistry)
  • "Efficient axonal transport of endolysosomes relies on the balanced ratio of microtubule tyrosination and detyrosination" (2024, Journal of Cell Science)

Frequent coauthors collaborating with Delagrange include:

  • Ralf Jockers
  • Leticia Peris
  • Marie-Jo Moutin
  • David Sugden
  • Saı̈d Yous

Their publications are often found in venues such as the IUPHAR/BPS Guide to Pharmacology CITE, European Neuropsychopharmacology, bioRxiv (Cold Spring Harbor Laboratory), ChemMedChem, and Brain.

Best Publications

  • Identification of the melatonin-binding site MT3 as the quinone reductase 2.

    Olivier Nosjean;Myriam Ferro;Francis Cogé;Philippe Beauverger

  • International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors

    Margarita L. Dubocovich;Philippe Delagrange;Diana N. Krause;David Sugden

  • Update on melatonin receptors: IUPHAR Review 20.

    Ralf Jockers;Ralf Jockers;Ralf Jockers;Philippe Delagrange;Margarita L. Dubocovich;Regina P. Markus

  • The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization

    Angélique Levoye;Julie Dam;Mohammed A Ayoub;Jean-Luc Guillaume

  • Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?

    R Jockers;R Jockers;P Maurice;P Maurice;J A Boutin;P Delagrange

  • Melatonin Reduces Body Weight Gain in Sprague Dawley Rats with Diet-Induced Obesity

    Bénédicte Prunet-Marcassus;Mathieu Desbazeille;Arnaud Bros;Katie Louche

  • New selective ligands of human cloned melatonin MT1 and MT2 receptors.

    Valérie Audinot;François Mailliet;Chantal Lahaye-Brasseur;Anne Bonnaud

  • Molecular tools to study melatonin pathways and actions

    Jean A. Boutin;Valérie Audinot;Gilles Ferry;Philippe Delagrange

  • IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels

    Anthony J. Harmar;Rebecca A. Hills;Edward M. Rosser;Martin Jones

  • Preferential Formation of MT1/MT2 Melatonin Receptor Heterodimers with Distinct Ligand Interaction Properties Compared with MT2 Homodimers

    Mohammed A. Ayoub;Angélique Levoye;Philippe Delagrange;Ralf Jockers

  • Comparative pharmacological studies of melatonin receptors: MT1, MT2 and MT3/QR2. Tissue distribution of MT3/QR2 .

    Olivier Nosjean;Jean-Paul Nicolas;Frederique Klupsch;Philippe Delagrange

  • Synthesis and structure-activity relationships of novel naphthalenic and bioisosteric related amidic derivatives as melatonin receptor ligands.

    Depreux P;Lesieur D;Mansour Ha;Morgan P

  • Functional expression of MT2 (Mel1b) melatonin receptors in human PAZ6 adipocytes.

    L Brydon;L Petit;P Delagrange;A D Strosberg

  • NRH:quinone reductase 2: An enzyme of surprises and mysteries

    Fanny Vella;Gilles Ferry;Philippe Delagrange;Jean A. Boutin

  • Agomelatine: mechanism of action and pharmacological profile in relation to antidepressant properties.

    B Guardiola-Lemaitre;C De Bodinat;P Delagrange;M J Millan

  • Chronic social defeat stress model: behavioral features, antidepressant action, and interaction with biological risk factors

    E. Venzala;A. L. García-García;N. Elizalde;P. Delagrange

  • Characterization of the melatoninergic MT3 binding site on the NRH:quinone oxidoreductase 2 enzyme.

    François Mailliet;Gilles Ferry;Fanny Vella;Sylvie Berger

  • Melatonin analogues as agonists and antagonists in the circadian system and other brain areas

    Shui-Wang Ying;Benjamin Rusak;Philippe Delagrange;Elisabeth Mocaër

  • Synthesis and structure-affinity-activity relationships of novel benzofuran derivatives as MT(2) melatonin receptor selective ligands.

    Valérie Wallez;Sophie Durieux-Poissonnier;Philippe Chavatte;Jean A. Boutin

  • Convergence of Melatonin and Serotonin (5-HT) Signaling at MT2/5-HT2C Receptor Heteromers

    Maud Kamal;Maud Kamal;Maud Kamal;Florence Gbahou;Florence Gbahou;Florence Gbahou;Jean-Luc Guillaume;Jean-Luc Guillaume;Jean-Luc Guillaume;Avais M. Daulat;Avais M. Daulat;Avais M. Daulat

Frequent Co-Authors

Jean A. Boutin
Jean A. Boutin Institut de Recherches Internationales Servier
Gérald Guillaumet
Gérald Guillaumet University of Orléans
Michael Spedding
Michael Spedding DuPont (United States)
Peter J. Morgan
Peter J. Morgan University of Aberdeen
Thérèse M. Jay
Thérèse M. Jay Centre national de la recherche scientifique, CNRS
Sylvain Rault
Sylvain Rault Université de Caen Normandie
Vincent Prevot
Vincent Prevot University of Lille
Michel Hamon
Michel Hamon Université Paris Cité
Luc Pénicaud
Luc Pénicaud Federal University of Toulouse Midi-Pyrénées

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