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Medicine

D-Index
75
Citations
19494
World Ranking
19158
National Ranking
9553

Overview

Margarita L. Dubocovich is affiliated with the University at Buffalo, State University of New York in the United States. Their research focuses primarily on neuroscience, with significant contributions centered on endocrine and autonomic systems, physiology, and cognitive neuroscience.

The main topics of their work include:

  • Circadian rhythm and melatonin
  • Sleep and wakefulness research
  • Receptor mechanisms and signaling
  • Neurobiology and insect physiology research
  • Dietary effects on health
  • Free radicals and antioxidants
  • Spaceflight effects on biology

Dubocovich has published in multiple venues, with frequent appearances in:

  • IUPHAR/BPS Guide to Pharmacology CITE
  • Journal of Pineal Research
  • The FASEB Journal
  • Nature
  • Journal of Pharmacology and Experimental Therapeutics

Some recent papers authored or co-authored by Dubocovich include:

  • "Virtual discovery of melatonin receptor ligands to modulate circadian rhythms," 2020, Nature
  • "Impact of endogenous melatonin on rhythmic behaviors, reproduction, and survival revealed in melatonin-proficient C57BL/6J congenic mice," 2021, Journal of Pineal Research
  • "Melatonin multifaceted pharmacological actions on melatonin receptors converging to abrogate COVID-19," 2021, Journal of Pineal Research
  • "Pharmacological Actions of Carbamate Insecticides at Mammalian Melatonin Receptors," 2020, Journal of Pharmacology and Experimental Therapeutics
  • "Low Doses of Ketamine and Melatonin in Combination Produce Additive Antidepressant-like Effects in Mice," 2021, International Journal of Molecular Sciences

Frequent co-authors in Dubocovich's work include:

  • Grant C. Glatfelter
  • Anthony Jones
  • Daniel P. Cardinali
  • Philippe Delagrange
  • Ralf Jockers

The body of research spans molecular biology and cellular and molecular neuroscience in addition to broader neuroscience topics. The investigation of melatonin's role in circadian rhythm regulation and receptor pharmacology appears central to their work, also extending to pharmacological interactions relevant to health and disease contexts, such as COVID-19 and antidepressant effects.

Best Publications

  • Functional MT1 and MT2 melatonin receptors in mammals.

    Margarita L. Dubocovich;Magdalena Markowska

  • International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors

    Margarita L. Dubocovich;Philippe Delagrange;Diana N. Krause;David Sugden

  • Melatonin is a potent modulator of dopamine release in the retina

    Margarita L. Dubocovich

  • Melatonin receptors: Are there multiple subtypes?

    Margarita L. Dubocovich

  • MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective

    Jiabei Liu;Shannon J. Clough;Anthony J. Hutchinson;Ekue B. Adamah-Biassi

  • Melatonin-Depleted Blood from Premenopausal Women Exposed to Light at Night Stimulates Growth of Human Breast Cancer Xenografts in Nude Rats

    David E. Blask;George C. Brainard;Robert T. Dauchy;John P. Hanifin

  • Molecular pharmacology, regulation and function of mammalian melatonin receptors.

    Margarita L Dubocovich;Moises A Rivera-Bermudez;Matthew J Gerdin;Monica I Masana

  • Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms

    Margarita L. Dubocovich;Kenneth Yun;Walid M. Al-ghoul;Susan Benloucif

  • Update on melatonin receptors: IUPHAR Review 20.

    Ralf Jockers;Ralf Jockers;Ralf Jockers;Philippe Delagrange;Margarita L. Dubocovich;Regina P. Markus

  • High-affinity [3H]imipramine binding in rat hypothalamus: association with uptake of serotonin but not of norepinephrine.

    SZ Langer;C Moret;R Raisman;ML Dubocovich

  • Melatonin receptors: Role on sleep and circadian rhythm regulation

    Margarita L. Dubocovich

  • Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor

    Margarita L. Dubocovich;Monica I. Masana;Stanca Iacob;Daniel M. Sauri

  • The Impact of School Daily Schedule on Adolescent Sleep

    Martha Hansen;Imke Janssen;Adam Schiff;Phyllis C. Zee

  • Pharmacology and function of melatonin receptors.

    Margarita L. Dubocovich

  • Activation of MT2 melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock

    Amanda E. Hunt;Walid M. Al-Ghoul;Martha U. Gillette;Margarita L. Dubocovich

  • Use of 2-[125I]iodomelatonin to characterize melatonin binding sites in chicken retina

    Margarita L. Dubocovich;Joseph S. Takahashi

  • Melatonin mediates two distinct responses in vascular smooth muscle

    Suzanne Doolen;Diana N Krause;Margarita L Dubocovich;Sue P Duckles

  • Luzindole (N-0774) : a novel melatonin receptor antagonist

    M L Dubocovich

  • Negative feedback regulation of noradrenaline release by nerve stimulation in the perfused cat's spleen: differences in potency of phenoxybenzamine in blocking the pre- and post-synaptic adrenergic receptors

    Margarita L. Dubocovich;S. Z. Langer

  • Phase-dependent treatment of delayed sleep phase syndrome with melatonin.

    Kavita Mundey;Susan Benloucif;Krisztina Harsanyi;Margarita L. Dubocovich

Frequent Co-Authors

Regina P. Markus
Regina P. Markus Universidade de São Paulo
Joseph S. Takahashi
Joseph S. Takahashi The University of Texas Southwestern Medical Center
Phyllis C. Zee
Phyllis C. Zee Northwestern University
Bryan L. Roth
Bryan L. Roth University of North Carolina at Chapel Hill
Richard J. Miller
Richard J. Miller Northwestern University
Philippe Delagrange
Philippe Delagrange Centre national de la recherche scientifique, CNRS
Brian K. Shoichet
Brian K. Shoichet University of California, San Francisco
Nancy R. Zahniser
Nancy R. Zahniser University of Colorado Denver
Martha U. Gillette
Martha U. Gillette University of Illinois at Urbana-Champaign

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