World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
15749
World Ranking
6415
National Ranking
187

Overview

Jean A. Boutin is affiliated with the Institut de Recherches Internationales Servier in France. Their research focuses primarily on biochemistry, genetics, molecular biology, neuroscience, and medicine, with a substantial contribution across 49 publications in biochemistry, genetics and molecular biology, 42 in neuroscience, and 28 in medicine.

The scientist has a strong emphasis on subfields such as molecular biology, endocrine and autonomic systems, cellular and molecular neuroscience, organic chemistry, and physiology. Their work covers diverse research topics including circadian rhythm and melatonin, receptor mechanisms and signaling, photoreceptor and optogenetics research, genomics, phytochemicals, oxidative stress, free radicals and antioxidants, neuroendocrine regulation and behavior, as well as monoclonal and polyclonal antibodies research.

Jean A. Boutin has published numerous papers, some of the recent contributions include:

  • Melatonin: Facts, Extrapolations and Clinical Trials, 2023, Biomolecules
  • Melatonin receptor ligands: A pharmaco-chemical perspective, 2020, Journal of Pineal Research
  • Melatonin controversies, an update, 2020, Journal of Pineal Research
  • Unraveling Plant Natural Chemical Diversity for Drug Discovery Purposes, 2020, Frontiers in Pharmacology

Frequent co-authors in Boutin's research include Gilles Ferry, Céline Legros, Elżbieta Janda, Jérôme Leprince, and Karine Reybier. The scientist has also contributed to multiple publications in notable venues such as Methods in Molecular Biology, Journal of Pineal Research, Receptors, Molecules, and Frontiers in Pharmacology, with the highest number of papers appearing in Methods in Molecular Biology (12 publications).

The scope and interdisciplinary nature of their work encompasses aspects of chemical biology related to melatonin and its receptors, drug discovery, and cellular signaling pathways.

Best Publications

  • Identification of the melatonin-binding site MT3 as the quinone reductase 2.

    Olivier Nosjean;Myriam Ferro;Francis Cogé;Philippe Beauverger

  • Peroxisome Proliferator-activated Receptor γ (PPARγ) as a Molecular Target for the Soy Phytoestrogen Genistein

    Zhi-Chao Dang;Valérie Audinot;Socrates E. Papapoulos;Jean A. Boutin

  • Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?

    R Jockers;R Jockers;P Maurice;P Maurice;J A Boutin;P Delagrange

  • New selective ligands of human cloned melatonin MT1 and MT2 receptors.

    Valérie Audinot;François Mailliet;Chantal Lahaye-Brasseur;Anne Bonnaud

  • Molecular tools to study melatonin pathways and actions

    Jean A. Boutin;Valérie Audinot;Gilles Ferry;Philippe Delagrange

  • Comment on "Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake"

    N. Chartrel;R. Alvear-Perez;J. Leprince;X. Iturrioz

  • Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states.

    Mark J. Millan;Adrian Newman‐Tancredi;Valérie Audinot;Didier Cussac

  • Comparative pharmacological studies of melatonin receptors: MT1, MT2 and MT3/QR2. Tissue distribution of MT3/QR2 .

    Olivier Nosjean;Jean-Paul Nicolas;Frederique Klupsch;Philippe Delagrange

  • Structure and expression of the human histamine H4-receptor gene.

    Francis Cogé;Sophie-Pénélope Guénin;Hervé Rique;Jean A. Boutin

  • Autotaxin Is Released from Adipocytes, Catalyzes Lysophosphatidic Acid Synthesis, and Activates Preadipocyte Proliferation UP-REGULATED EXPRESSION WITH ADIPOCYTE DIFFERENTIATION AND OBESITY

    Gilles Ferry;Edwige Tellier;Anne Try;Sandra Grés

  • Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis

    Surajit Ganguly;Jonathan A. Gastel;Joan L. Weller;Christian Schwartz

  • NRH:quinone reductase 2: An enzyme of surprises and mysteries

    Fanny Vella;Gilles Ferry;Philippe Delagrange;Jean A. Boutin

  • Unraveling Plant Natural Chemical Diversity for Drug Discovery Purposes

    Emmanuelle Lautié;Olivier Russo;Pierre Ducrot;Jean A. Boutin

  • Genomic organization and characterization of splice variants of the human histamine H3 receptor.

    Francis Cogé;Sophie-Pénélope Guénin;Valérie Audinot;Anne Renouard-Try

  • New .alpha.-amino phosphonic acid derivatives of vinblastine: chemistry and antitumor activity

    Gilbert Lavielle;Patrick Hautefaye;Corinne Schaeffer;Jean A. Boutin

  • Natural ligands of PPARgamma: are prostaglandin J(2) derivatives really playing the part?

    Olivier Nosjean;Jean A Boutin

  • Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization.

    Adeline Giganti;Marianne Rodriguez;Benjamin Fould;Natacha Moulharat

  • Characterization of the melatoninergic MT3 binding site on the NRH:quinone oxidoreductase 2 enzyme.

    François Mailliet;Gilles Ferry;Fanny Vella;Sylvie Berger

  • S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool.

    Gilles Ferry;Natacha Moulharat;Jean-Philippe Pradère;Patrice Desos

  • The role of the matrix metalloproteinases during in vitro vessel formation.

    Burbridge Mf;Cogé F;Galizzi Jp;Boutin Ja

Frequent Co-Authors

Philippe Delagrange
Philippe Delagrange Centre national de la recherche scientifique, CNRS
Mark J. Millan
Mark J. Millan University of Glasgow
Jean-Daniel Brion
Jean-Daniel Brion Centre national de la recherche scientifique, CNRS
Hubert Vaudry
Hubert Vaudry University of Rouen
Gérald Guillaumet
Gérald Guillaumet University of Orléans
Jean-Louis Nahon
Jean-Louis Nahon Centre national de la recherche scientifique, CNRS
Ming-Wei Wang
Ming-Wei Wang Chinese Academy of Sciences
Jérôme Leprince
Jérôme Leprince University of Rouen

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