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Chemistry

D-Index
57
Citations
9136
World Ranking
11351
National Ranking
433

Overview

Jean-Daniel Brion is affiliated with the Centre national de la recherche scientifique (CNRS) in France. Their research primarily pertains to the field of medicine, with particular contributions across various subfields including molecular biology, infectious diseases, organic chemistry, physiology, and oncology.

The scientist's main topics of work encompass biochemical and molecular research, HIV/AIDS drug development and treatment, synthesis and biological activity, tuberous sclerosis complex research, polyomavirus and related diseases, as well as epilepsy research and treatment.

Jean-Daniel Brion has published scholarly articles in notable venues such as:

  • European Journal of Medicinal Chemistry
  • Epilepsia

Their recent papers include:

  • Identification of a new series of flavopiridol-like structures as kinase inhibitors with high cytotoxic potency, 2020, European Journal of Medicinal Chemistry
  • GluN2C selective inhibition is a target to develop new antiepileptic compounds, 2022, Epilepsia

Frequent coauthors in their research encompass:

  • Samir Messaoudi
  • Mouâd Alami
  • Nada Ibrahim
  • Pascal Bonnet
  • Jean-François Peyrat

The diversity of their research topics and publication venues suggests a multidisciplinary approach within medical sciences, focusing on both molecular mechanisms and clinical applications related to neurological and infectious diseases, among others.

Best Publications

  • Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent.

    Samir Messaoudi;Bret Tréguier;Abdallah Hamze;Olivier Provot

  • Transition-Metal-Catalyzed Direct C–H Alkenylation, Alkynylation, Benzylation, and Alkylation of (Hetero)arenes

    Samir Messaoudi;Jean-Daniel Brion;Mouâd Alami

  • Palladium(II)-Catalyzed Oxidative Arylation of Quinoxalin-2(1H)-ones with Arylboronic Acids

    Amandine Carrër;Jean-Daniel Brion;Samir Messaoudi;Mouad Alami

  • New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90.

    Gaëlle Le Bras;Christine Radanyi;Jean-François Peyrat;Jean-Daniel Brion

  • Discovery of Isoerianin Analogues as Promising Anticancer Agents

    Samir Messaoudi;Abdallah Hamze;Olivier Provot;Bret Tréguier

  • Recent Advances in Hsp90 Inhibitors as Antitumor Agents

    Samir Messaoudi;Jean F. Peyrat;Jean D. Brion;Mouâd Alami

  • DMSO–PdI2 as a powerful oxidizing couple of alkynes into benzils: one-pot synthesis of nitrogen-containing five- or six-membered heterocycles

    Céline Mousset;Olivier Provot;Abdallah Hamze;Jérôme Bignon

  • Synthesis and antitumor activity of benzils related to combretastatin A-4

    Céline Mousset;Anne Giraud;Olivier Provot;Abdallah Hamze

  • Expeditious synthesis of 1,1-diarylethylenes related to isocombretastatin A-4 (isoCA-4) via palladium-catalyzed arylation of N-tosylhydrazones with aryl triflates

    Bret Tréguier;Abdallah Hamze;Olivier Provot;Jean-Daniel Brion

  • Pd-catalyzed reaction of sterically hindered hydrazones with aryl halides: synthesis of tetra-substituted olefins related to iso-combretastatin A4.

    Etienne Brachet;Abdallah Hamze;Jean-François Peyrat;Jean-Daniel Brion

  • Microwave-assisted Pd(OH)2-catalyzed direct C−H arylation of free-(NH2) adenines with aryl halides

    Sophian Sahnoun;Samir Messaoudi;Jean Francois Peyrat;Jean-Daniel Brion

  • Copper-catalyzed reductive coupling of tosylhydrazones with amines: A convenient route to α-branched amines

    Abdallah Hamze;Bret Tréguier;Jean-Daniel Brion;Mouâd Alami

  • Synthesis, biological evaluation of 1,1-diarylethylenes as a novel class of antimitotic agents.

    Abdallah Hamze;Anne Giraud;Samir Messaoudi;Olivier Provot

  • Synthesis and biological activity of simplified denoviose-coumarins related to novobiocin as potent inhibitors of heat-shock protein 90 (hsp90).

    Christine Radanyi;Gaëlle Le Bras;Samir Messaoudi;Céline Bouclier

  • Palladium-catalyzed decarboxylative coupling of quinolinone-3-carboxylic acids and related heterocyclic carboxylic acids with (hetero)aryl halides.

    Samir Messaoudi;Jean-Daniel Brion;Mouad Alami

  • p-Toluenesulfonic acid-promoted selective functionalization of unsymmetrical arylalkynes: a regioselective access to various arylketones and heterocycles

    Maud Jacubert;Olivier Provot;Jean-François Peyrat;Abdallah Hamze

  • Platinum oxide catalyzed silylation of aryl halides with triethylsilane: an efficient synthetic route to functionalized aryltriethylsilanes.

    Abdallah Hamze;Olivier Provot;Mouâd Alami;Jean-Daniel Brion

  • Assisted Tandem Palladium(II)/Palladium(0)-Catalyzed C- and N-Arylations of Quinoxalin-2(1 H)-ones in Water

    Amandine Carrër;Jean-Daniel Brion;Mouad Alami;Samir Messaoudi

  • Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors.

    Ilhem Khelifi;Timothée Naret;Dolor Renko;Abdallah Hamze

  • An Expeditious Copper‐Catalyzed Access to 3‐Aminoquinolinones, 3‐Aminocoumarins and Anilines using Sodium Azide

    Samir Messaoudi;Jean-Daniel Brion;Mouâd Alami

  • A General Copper Powder-Catalyzed Ullmann-Type Reaction of 3-Halo-4(1H)-quinolones With Various Nitrogen-Containing Nucleophiles

    Davide Audisio;Samir Messaoudi;Jean-François Peyrat;Jean-Daniel Brion

Frequent Co-Authors

Mouad Alami
Mouad Alami Centre national de la recherche scientifique, CNRS
Samir Messaoudi
Samir Messaoudi University of Paris-Saclay
Mark J. Millan
Mark J. Millan University of Glasgow
Pietro Ghezzi
Pietro Ghezzi Brighton and Sussex Medical School
Jean A. Boutin
Jean A. Boutin Institut de Recherches Internationales Servier
Jack-Michel Renoir
Jack-Michel Renoir Institut Gustave Roussy
Thierry Prangé
Thierry Prangé Université Paris Cité
Montserrat Gómez
Montserrat Gómez Paul Sabatier University
Jean Feuillard
Jean Feuillard University of Limoges
Patrick Couvreur
Patrick Couvreur University of Paris-Saclay

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