World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
69
Citations
12292
World Ranking
7586
National Ranking
3447

Overview

Brian S. J. Blagg is affiliated with the University of Notre Dame in the United States. Their research primarily falls within the broad field of Biochemistry, Genetics, and Molecular Biology, with a focus on several subfields including Molecular Biology, Computational Theory and Mathematics, Materials Chemistry, Physiology, and Cell Biology.

The scientist's main topics of research include Heat shock proteins research, ATP Synthase and ATPases Research, Computational Drug Discovery Methods, Endoplasmic Reticulum Stress and Disease, thermodynamics and calorimetric analyses, Protein Structure and Dynamics, and Enzyme Structure and Function.

Brian S. J. Blagg has published extensively, with recent papers including:

  • A first-in-class polymerase theta inhibitor selectively targets homologous-recombination-deficient tumors, 2021, Nature Cancer
  • The heat shock response and small molecule regulators, 2021, European Journal of Medicinal Chemistry
  • The disruption of protein−protein interactions with co-chaperones and client substrates as a strategy towards Hsp90 inhibition, 2020, Acta Pharmaceutica Sinica B
  • The role and therapeutic potential of Hsp90, Hsp70, and smaller heat shock proteins in peripheral and central neuropathies, 2020, Medicinal Research Reviews
  • The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition, 2021, Journal of Medicinal Chemistry

Frequent co-authors collaborating with Brian S. J. Blagg include:

  • Sanket J. Mishra
  • Christopher M. Brackett
  • John M. Streicher
  • Bradley M. Keegan
  • Monimoy Banerjee

Their research has appeared repeatedly in several publication venues, notably:

  • ACS Medicinal Chemistry Letters
  • European Journal of Medicinal Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Bioorganic & Medicinal Chemistry Letters
  • Cancer Research

Best Publications

  • Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket.

    Alison Donnelly;Brian S J Blagg

  • Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of hsp90.

    Joseph A. Burlison;Len Neckers;Andrew B. Smith;and Anthony Maxwell

  • Hsp90 inhibitors: small molecules that transform the Hsp90 protein folding machinery into a catalyst for protein degradation.

    Brian S. J. Blagg;Timothy D. Kerr

  • A first-in-class polymerase theta inhibitor selectively targets homologous-recombination-deficient tumors

    Jia Zhou;Camille Gelot;Constantia Pantelidou;Adam Li

  • Hsp90 inhibitors identified from a library of novobiocin analogues.

    Xiao Ming Yu;Gang Shen;Len Neckers;Helen Blake

  • Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function.

    Mehdi Mollapour;Shinji Tsutsumi;Alison C. Donnelly;Kristin Beebe

  • Engineering an antibiotic to fight cancer: Optimization of the novobiocin scaffold to produce anti-proliferative agents

    Huiping Zhao;Alison C. Donnelly;Bhaskar R. Kusuma;Gary E. L. Brandt

  • Gedunin, a Novel Hsp90 Inhibitor: Semisynthesis of Derivatives and Preliminary Structure–Activity Relationships

    Gary E. L. Brandt;Matthew D. Schmidt;Thomas E. Prisinzano;Brian S. J. Blagg

  • The design, synthesis, and evaluation of coumarin ring derivatives of the novobiocin scaffold that exhibit antiproliferative activity.

    Alison C. Donnelly;Jared R. Mays;Joseph A. Burlison;John T. Nelson

  • E. coli MEP synthase: steady-state kinetic analysis and substrate binding.

    Andrew T. Koppisch;David T. Fox;Brian S. J. Blagg;C. D. Poulter

  • Development of novobiocin analogues that manifest anti-proliferative activity against several cancer cell lines.

    Joseph A. Burlison;Christopher Avila;George Vielhauer;Donna J. Lubbers

  • Gedunin Inactivates the Co-chaperone p23 Protein Causing Cancer Cell Death by Apoptosis

    Chaitanya A. Patwardhan;Abdul Fauq;Laura B. Peterson;Charles Miller

  • Anticancer Inhibitors of Hsp90 Function: Beyond the Usual Suspects.

    Gaurav Garg;Anuj Khandelwal;Brian S.J. Blagg

  • A non-toxic Hsp90 inhibitor protects neurons from Aβ-induced toxicity

    Sabah Ansar;Joseph A. Burlison;M. Kyle Hadden;Xiao Ming Yu

  • Intramolecular Diels−Alder and Tandem Intramolecular Diels−Alder/1,3-Dipolar Cycloaddition Reactions of 1,3,4-Oxadiazoles

    Gordon D. Wilkie;Gregory I. Elliott;Brian S. J. Blagg;Scott E. Wolkenberg

  • Old and New Approaches to Target the Hsp90 Chaperone

    Jackee Sanchez;Trever R Carter;Mark S Cohen;Brian S J Blagg

  • Gambogic acid, a natural product inhibitor of Hsp90.

    Jason Davenport;Jacob R. Manjarrez;Laura B. Peterson;Brian Krumm

  • Hsp90: a novel target for the disruption of multiple signaling cascades.

    Stephanie C. Bishop;Joseph A. Burlison;Brian S. J. Blagg

  • Gamendazole, an Orally Active Indazole Carboxylic Acid Male Contraceptive Agent, Targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and Stimulates Il1a Transcription in Rat Sertoli Cells

    Joseph S. Tash;Ramappa Chakrasali;Sudhakar R. Jakkaraj;Jennifer Hughes

  • Development of a Grp94 inhibitor

    Adam S. Duerfeldt;Laura B. Peterson;Jason C. Maynard;Chun Leung Ng

Frequent Co-Authors

Robert L. Matts
Robert L. Matts Oklahoma State University
Chad A. Dickey
Chad A. Dickey University of South Florida
Leonard M. Neckers
Leonard M. Neckers National Institutes of Health
Dale L. Boger
Dale L. Boger Scripps Research Institute
C. Dale Poulter
C. Dale Poulter University of Utah
William G. Stetler-Stevenson
William G. Stetler-Stevenson National Institutes of Health
Jane B. Trepel
Jane B. Trepel National Institutes of Health
Jeffrey Aubé
Jeffrey Aubé University of North Carolina at Chapel Hill
Charles Redwood
Charles Redwood University of Oxford
Hugh Watkins
Hugh Watkins University of Oxford

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

A background in Biology and Biochemistry opens doors to a range of online degree programs and dynamic career options in the healthcare and science sectors. Diverse online pathways, from nutrition to medical imaging, are now accessible for students seeking flexible learning and career advancement.

For those interested in food science and health, pursuing a cost of masters degree in nutrition can help you understand program pricing, budgets, and financial aid opportunities. Meanwhile, if your interests lie in patient diagnostics or technology, online sonography programs offer a pathway into medical imaging, typically with minimal on-site requirements.

Similarly, rad tech online programs allow students to start a career in radiologic technology, emphasizing both technical and patient care skills. For those aiming to become a registered dietitian, exploring the best dietetics programs can provide guidance on accredited online curriculum and career outcomes in nutrition and wellness.

Each of these online degree options provides unique pathways for Biology and Biochemistry students to specialize and succeed in rapidly growing healthcare fields.

Best Scientists Citing Brian S. J. Blagg

Trending Scientists

Recently Published Articles