What is he best known for?
The fields of study he is best known for:
His primary scientific interests are in Hsp90, Biochemistry, Cell biology, Stereochemistry and Hsp90 inhibitor.
He specializes in Hsp90, namely Geldanamycin.
His work in the fields of Biochemistry, such as Novobiocin, Natural product, Enzyme inhibitor and Enzyme, overlaps with other areas such as DNA gyrase.
Brian S. J. Blagg works mostly in the field of Natural product, limiting it down to concerns involving Structure–activity relationship and, occasionally, Molecular conformation, MEDLINE and Topoisomerase-II Inhibitor.
In the subject of general Cell biology, his work in Chaperone and Phosphorylation is often linked to Wee1 and Eukaryotic translation elongation factor 1 alpha 1, thereby combining diverse domains of study.
His Stereochemistry research is multidisciplinary, incorporating elements of Diels alder, Uncompetitive inhibitor and Cycloaddition, 1,3-Dipolar cycloaddition.
His most cited work include:
- Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket. (220 citations)
- Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of hsp90. (191 citations)
- Hsp90 inhibitors: small molecules that transform the Hsp90 protein folding machinery into a catalyst for protein degradation. (149 citations)
What are the main themes of his work throughout his whole career to date?
Brian S. J. Blagg focuses on Hsp90, Biochemistry, Stereochemistry, Novobiocin and Cell biology.
He works on Hsp90 which deals in particular with Geldanamycin.
His Natural product, Binding site, Cell growth and Enzyme inhibitor study in the realm of Biochemistry interacts with subjects such as Hsp90 inhibitor.
The study incorporates disciplines such as Stereoisomerism, Ring, Amide, Structure–activity relationship and Chemical synthesis in addition to Stereochemistry.
In his research, Combinatorial chemistry is intimately related to Coumarin, which falls under the overarching field of Novobiocin.
His work on Endoplasmic reticulum and Plasma protein binding as part of general Cell biology study is frequently connected to Myocilin and Heat shock, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them.
He most often published in these fields:
- Hsp90 (42.54%)
- Biochemistry (31.14%)
- Stereochemistry (20.61%)
What were the highlights of his more recent work (between 2015-2020)?
- Hsp90 (42.54%)
- Biochemistry (31.14%)
- Cell biology (11.84%)
In recent papers he was focusing on the following fields of study:
Brian S. J. Blagg mostly deals with Hsp90, Biochemistry, Cell biology, Pharmacology and Stereochemistry.
Hsp90 is integrated with Novobiocin, Chaperone, Combinatorial chemistry, Sugar and Protein folding in his study.
His studies deal with areas such as Structure–activity relationship and Cell growth as well as Novobiocin.
His research in the fields of Natural product, Binding site and In vitro overlaps with other disciplines such as Troponin complex and Troponin T.
His Pharmacology study integrates concerns from other disciplines, such as Peripheral neuropathy and Cancer.
The concepts of his Stereochemistry study are interwoven with issues in Biological evaluation, Neuroprotection, Coumarin and Amide.
Between 2015 and 2020, his most popular works were:
- Natural Product Inspired N-Terminal Hsp90 Inhibitors: From Bench to Bedside? (64 citations)
- Anticancer Inhibitors of Hsp90 Function: Beyond the Usual Suspects. (55 citations)
- Hsp90 activator Aha1 drives production of pathological tau aggregates. (43 citations)
In his most recent research, the most cited papers focused on:
His main research concerns Hsp90, Biochemistry, Cell biology, Endoplasmic reticulum and Glucose-regulated protein.
His Hsp90 research encompasses a variety of disciplines, including Sugar and Novobiocin.
His research investigates the link between Novobiocin and topics such as Clinical evaluation that cross with problems in Cell growth.
His primary area of study in Biochemistry is in the field of Chaperone.
His biological study spans a wide range of topics, including Natural product, Plasma protein binding and Drug discovery.
His study in Cell biology is interdisciplinary in nature, drawing from both Neurotoxicity and Activator.
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