Jane B. Trepel

Overview

Best Publications

• Targeting the dynamic HSP90 complex in cancer

  Jane Trepel;Mehdi Mollapour;Giuseppe Giaccone;Len Neckers

  1679
  Citations

• HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability

  Jennifer S. Isaacs;Yun Jin Jung;David R. Mole;Sunmin Lee

  1263
  Citations

• IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis.

  Yun-Jin Jung;Jennifer S. Isaacs;Sunmin Lee;Jane Trepel

  951
  Citations

• Taxol-induced Apoptosis and Phosphorylation of Bcl-2 Protein Involves c-Raf-1 and Represents a Novel c-Raf-1 Signal Transduction Pathway

  Mikhail V. Blagosklonny;Theodor Schulte;Phuongmai Nguyen;Jane Trepel

  551
  Citations

• The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties.

  Sara J. Felts;Barbara A.L. Owen;PhuongMai Nguyen;Jane Trepel

  516
  Citations

• Randomized Phase II, Double-Blind, Placebo-Controlled Study of Exemestane With or Without Entinostat in Postmenopausal Women With Locally Recurrent or Metastatic Estrogen Receptor-Positive Breast Cancer Progressing on Treatment With a Nonsteroidal Aromatase Inhibitor

  Denise A. Yardley;Roohi R. Ismail-Khan;Bohuslav Melichar;Mikhail Lichinitser

  492
  Citations

• Phase I and Pharmacokinetic Study of MS-275, a Histone Deacetylase Inhibitor, in Patients With Advanced and Refractory Solid Tumors or Lymphoma

  Qin C. Ryan;Donna Headlee;Milin Acharya;Alex Sparreboom

  486
  Citations

• Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer

  Alain Thibault;Dvorit Samid;Dvorit Samid;Anne C. Tompkins;William D. Figg

  482
  Citations

• p53 Inhibits Hypoxia-inducible Factor-stimulated Transcription *

  Mikhail V. Blagosklonny;Won G. An;Larisa Y. Romanova;Jane Trepel

  406
  Citations

• Curcumin is an Inhibitor of p300 Histone Acetylatransferase

  Len Neckers;Jane Trepel;Sunmin Lee;Eun-Joo Chung

  397
  Citations

• p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.

  Christine Chavany;Edward Mimnaugh;Penny Miller;Roberto Bitton

  396
  Citations

• Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway.

  T W Schulte;M V Blagosklonny;L Romanova;J F Mushinski

  384
  Citations

• Metastasis-associated differences in gene expression in a murine model of osteosarcoma.

  Chand Khanna;Javed Khan;Phoungmai Nguyen;Jennifer Prehn

  375
  Citations

• Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias

  Ivana Gojo;Anchalee Jiemjit;Jane B. Trepel;Alex Sparreboom

  367
  Citations

• Update on Hsp90 inhibitors in clinical trial.

  Y. S. Kim;S. V. Alarcon;S. Lee;M.-J. Lee

  360
  Citations

• Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis.

  Mercedes Garayoa;Alfredo Martínez;Sunmin Lee;Rubén Pío

  337
  Citations

• Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines.

  Patrick G. Johnston;James C. Drake;Jane Trepel;Carmen J. Allegra

  336
  Citations

• Histopathologic staging at initial diagnosis of mycosis fungoides and the Sézary syndrome: definition of three distinctive prognostic groups

  Edward A. Sausville;Joyce L. Eddy;Robert W. Makuch;A. B. Fischmann

  322
  Citations

• Terminal neuroendocrine differentiation of human prostate carcinoma cells in response to increased intracellular cyclic AMP

  Y J Bang;F Pirnia;W G Fang;W K Kang

  320
  Citations

• Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1α Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species

  Sunil Sudarshan;Carole Sourbier;Hye Sik Kong;Karen L Block

  300
  Citations