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D-Index & Metrics

Medicine

D-Index
113
Citations
60374
World Ranking
4862
National Ranking
478

Overview

Roger G. Pertwee is affiliated with the University of Aberdeen in the United Kingdom, focusing research efforts predominantly in the areas of medicine and neuroscience. The principal fields of study encompass medicine with 28 publications and neuroscience with 16 publications. Their work extends into specialized subfields including pharmacology, cellular and molecular neuroscience, molecular biology, materials chemistry, and physiology.

Their research extensively covers topics such as cannabis and cannabinoid research, which appears in 42 publications. Additional focus areas include neuroscience and neuropharmacology research, neurotransmitter receptor influence on behavior, pharmacological receptor mechanisms and effects, crystallization and solubility studies, X-ray diffraction in crystallography, and adenosine and purinergic signaling.

Pertwee has published in several scientific venues, with frequent contributions to the International Journal of Molecular Sciences and The Cambridge Structural Database, each hosting four publications. Other common venues include the Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry, and Bioorganic & Medicinal Chemistry, each with two publications.

Recent papers authored or coauthored by Roger G. Pertwee include:

  • Discovery of a Biased Allosteric Modulator for Cannabinoid 1 Receptor: Preclinical Anti-Glaucoma Efficacy, 2021, Journal of Medicinal Chemistry
  • Therapeutic Potential of Cannabidiol, Cannabidiolic Acid, and Cannabidiolic Acid Methyl Ester as Treatments for Nausea and Vomiting, 2021, Cannabis and Cannabinoid Research
  • Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands, 2022, Journal of Medicinal Chemistry
  • Effects on the Post-translational Modification of H3K4Me3, H3K9ac, H3K9Me2, H3K27Me3, and H3K36Me2 Levels in Cerebral Cortex, Hypothalamus and Pons of Rats after a Systemic Administration of Cannabidiol: A Preliminary Study, 2020, Central Nervous System Agents in Medicinal Chemistry
  • Variously substituted 2-oxopyridine derivatives: Extending the structure-activity relationships for allosteric modulation of the cannabinoid CB2 receptor, 2020, European Journal of Medicinal Chemistry

Pertwee collaborates frequently with other researchers in the field. Notable coauthors include Robert B. Laprairie (11 joint works), Sumanta Garai (7 joint works), Mary E. Abood (7 joint works), Ganesh A. Thakur (7 joint works), and Francesca Gado (7 joint works).

Best Publications

  • ISOLATION AND STRUCTURE OF A BRAIN CONSTITUENT THAT BINDS TO THE CANNABINOID RECEPTOR

    William A. Devane;Lumir Hanuš;Aviva Breuer;Roger G. Pertwee

  • International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors

    A C Howlett;F Barth;T I Bonner;G Cabral

  • Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.

    Raphael Mechoulam;Shimon Ben-Shabat;Lumir Hanus;Moshe Ligumsky

  • The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin

    R G Pertwee

  • PHARMACOLOGY OF CANNABINOID CB1 AND CB2 RECEPTORS

    Roger G. Pertwee

  • International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

    Roger Guy Pertwee;A. C. Howlett;M. E. Abood;S. P. H. Alexander

  • Cannabinoid receptors and pain.

    Roger Guy Pertwee

  • Cannabinoid pharmacology: the first 66 years

    Roger G Pertwee

  • Pharmacological actions of cannabinoids.

    R. G. Pertwee

  • Cannabinoids control spasticity and tremor in a multiple sclerosis model.

    D Baker;G Pryce;J L Croxford;P Brown

  • Cannabinoid receptors and their ligands

    Roger G Pertwee;Ruth Ross

  • Pharmacology of cannabinoid receptor ligands.

    Pertwee Rg

  • HU-308: A specific agonist for CB2, a peripheral cannabinoid receptor

    L. Hanuš;A. Breuer;S. Tchilibon;S. Shiloah

  • Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro

    Adele Thomas;Gemma Baillie;A. M. Phillips;R. K. Razdan

  • The pharmacology of cannabinoid receptors and their ligands: an overview.

    Roger Guy Pertwee

  • Inverse agonism and neutral antagonism at cannabinoid CB1 receptors

    Roger G. Pertwee

  • Emerging strategies for exploiting cannabinoid receptor agonists as medicines

    Roger G Pertwee

  • Are cannabidiol and Δ9‐tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review

    John M McPartland;Marnie Duncan;Vincenzo Di Marzo;Roger G Pertwee

  • Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists.

    Ruoxi Lan;Qian Liu;Pusheng Fan;Sonyuan Lin

  • Synthesis and Characterization of Potent and Selective Agonists of the Neuronal Cannabinoid Receptor (CB1)

    Cecilia J. Hillard;Sukumar Manna;Marcie J. Greenberg;Ralph DiCamelli

Frequent Co-Authors

Raphael Mechoulam
Raphael Mechoulam Hebrew University of Jerusalem
Vincenzo Di Marzo
Vincenzo Di Marzo National Research Council (CNR)
Raj K. Razdan
Raj K. Razdan Organix (United States)
Gernot Riedel
Gernot Riedel University of Aberdeen
Alexandros Makriyannis
Alexandros Makriyannis Northeastern University
David Baker
David Baker University of Washington
Gareth Pryce
Gareth Pryce Queen Mary University of London
Bettina Platt
Bettina Platt University of Aberdeen
Ken Mackie
Ken Mackie Indiana University
Gavin Giovannoni
Gavin Giovannoni Queen Mary University of London

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