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Chemistry

D-Index
64
Citations
21647
World Ranking
7916
National Ranking
2297

Overview

Philip J. Hajduk is affiliated with the National Institutes of Health in the United States. Their research spans the fields of Biochemistry, Genetics, Molecular Biology, and Medicine, with particular focus on Molecular Biology, Genetics, and Immunology as subfields. Their work covers topics including Biochemical and Molecular Research, Toxin Mechanisms and Immunotoxins, Chronic Lymphocytic Leukemia Research, Myeloproliferative Neoplasms: Diagnosis and Treatment, and Cancer-related gene regulation.

Hajduk has contributed to multiple scientific publications. Notable recent papers include:

  • Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design, 2020, Journal of Medicinal Chemistry
  • Leveraging a Billion-Edge Knowledge Graph for Drug Re-purposing and Target Prioritization using Genomically-Informed Subgraphs, 2022, bioRxiv (Cold Spring Harbor Laboratory)

Their frequent coauthors consist of Justin Dietrich, Kenton L. Longenecker, Noel S. Wilson, Christian Goess, and Sanjay C. Panchal.

Hajduk's work has appeared primarily in the Journal of Medicinal Chemistry and bioRxiv (Cold Spring Harbor Laboratory).

Best Publications

  • An inhibitor of Bcl-2 family proteins induces regression of solid tumours

    Tilman Oltersdorf;Steven W. Elmore;Alexander R. Shoemaker;Robert C. Armstrong

  • Discovering High-Affinity Ligands for Proteins: SAR by NMR

    Suzanne B. Shuker;Philip J. Hajduk;Robert P. Meadows;Stephen W. Fesik

  • Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate.

    John E. Harlan;Philip J. Hajduk;Ho Sup Yoon;Stephen W. Fesik

  • A decade of fragment-based drug design: strategic advances and lessons learned

    Unknown

  • Druggability indices for protein targets derived from NMR-based screening data.

    Philip J. Hajduk;and Jeffrey R. Huth;Stephen W. Fesik

  • One-Dimensional Relaxation- and Diffusion-Edited NMR Methods for Screening Compounds That Bind to Macromolecules

    Philip J. Hajduk;and Edward T. Olejniczak;Stephen W. Fesik

  • Discovery of Potent Nonpeptide Inhibitors of Stromelysin Using SAR by NMR

    P. J. Hajduk;G. Sheppard;D. G. Nettesheim;E. T. Olejniczak

  • Privileged molecules for protein binding identified from NMR-based screening.

    Philip J. Hajduk;Mark Bures;Jens Praestgaard;Stephen W. Fesik

  • Structural Characterization of a Soluble Amyloid β-Peptide Oligomer

    Liping Yu;Rohinton Edalji;John E. Harlan;Thomas F. Holzman

  • Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-xL from NMR and Parallel Synthesis

    Andrew M. Petros;Jurgen Dinges;David J. Augeri;Steven A. Baumeister

  • Predicting protein druggability.

    Philip J. Hajduk;Jeffrey R. Huth;Christin Tse

  • Navigating the kinome

    James T Metz;Eric F Johnson;Niru B Soni;Philip J Merta

  • Fragment-Based Drug Design: How Big Is Too Big?

    Philip J. Hajduk

  • Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy

    Bruce G Szczepankiewicz;Gang Liu;Philip J Hajduk;Cele Abad-Zapatero

  • Discovering High-Affinity Ligands for Proteins

    Philip J Hajduk;Robert P. Meadows;Stephen W. Fesik

  • NMR-based screening in drug discovery.

    Philip J. Hajduk;Robert P. Meadows;Stephen W. Fesik

  • Structure of the N-terminal RNA-binding domain of the SARS CoV nucleocapsid protein.

    Qiulong Huang;Liping Yu;Andrew M Petros;Angelo Gunasekera

  • NMR-Based Screening of Proteins Containing 13C-Labeled Methyl Groups

    Philip J. Hajduk;David J. Augeri;Jamey Mack;Renaldo Mendoza

  • Solution structure of a pleckstrin-homology domain.

    Ho Sup Yoon;Philip J. Hajduk;Andrew M. Petros;Edward T. Olejniczak

  • High-throughput nuclear magnetic resonance-based screening.

    Philip J. Hajduk;Tobias Gerfin;Jean-Marc Boehlen;Markus Häberli

  • ALARM NMR: a rapid and robust experimental method to detect reactive false positives in biochemical screens.

    Jeffrey R Huth;Renaldo Mendoza;Edward T Olejniczak;Robert W Johnson

Frequent Co-Authors

Stephen W. Fesik
Stephen W. Fesik Vanderbilt University
Edward T. Olejniczak
Edward T. Olejniczak Vanderbilt University
Saul H. Rosenberg
Saul H. Rosenberg AbbVie (United States)
Jun Chen
Jun Chen Nankai University
Eric F. Johnson
Eric F. Johnson AbbVie (United States)
Richard D. Smith
Richard D. Smith Pacific Northwest National Laboratory
Robert E. Johnson
Robert E. Johnson The University of Texas Medical Branch at Galveston
David Levens
David Levens National Institutes of Health

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