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D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
17400
World Ranking
6667
National Ranking
3100

Overview

Maurizio Pellecchia is affiliated with the University of California, Riverside in the United States. Their research output spans multiple fields intersecting biochemistry, molecular biology, and medicine, with a focus on molecular interactions and chemical synthesis related to disease mechanisms. The scientist's work is represented through numerous publications, particularly in the areas of biochemical and molecular research, with an emphasis on click chemistry, axon guidance, and peptidase inhibition.

The main fields of study for Pellecchia include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Their subfields of study cover:

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Organic Chemistry
  • Oncology
  • Infectious Diseases

In terms of research topics, Pellecchia's work encompasses:

  • Click Chemistry and Applications
  • Axon Guidance and Neuronal Signaling
  • Peptidase Inhibition and Analysis
  • Chemical Synthesis and Analysis
  • Biochemical and Molecular Research
  • Signaling Pathways in Disease
  • Monoclonal and Polyclonal Antibodies Research

Notable recent papers authored or co-authored by Pellecchia include:

  • Therapeutic Targeting of MMP-12 for the Treatment of Chronic Obstructive Pulmonary Disease, 2020, Journal of Medicinal Chemistry
  • Design, Synthesis, and Structural Characterization of Lysine Covalent BH3 Peptides Targeting Mcl-1, 2021, Journal of Medicinal Chemistry
  • Stability and Cell Permeability of Sulfonyl Fluorides in the Design of Lys-Covalent Antagonists of Protein-Protein Interactions, 2020, ChemMedChem
  • Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist, 2023, Journal of Medicinal Chemistry
  • Lysine Covalent Antagonists of Melanoma Inhibitors of Apoptosis Protein, 2021, Journal of Medicinal Chemistry

Pellecchia frequently collaborates with colleagues such as Carlo Baggio, Parima Udompholkul, Giulia Alboreggia, Luca Gambini, and Zahra Assar, reflecting consistent partnerships in the production of scientific knowledge.

The scientist's publications are predominantly found in these venues:

  • Journal of Medicinal Chemistry
  • Molecules
  • ChemMedChem
  • Cancers
  • Proceedings of the National Academy of Sciences

Best Publications

  • A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

    Nunzio Bottini;Lucia Musumeci;Andres Alonso;Souad Rahmouni

  • Nmr in drug discovery

    Maurizio Pellecchia;Daniel S. Sem;Kurt Wüthrich;Kurt Wüthrich

  • Apoptosis-based therapies for hematologic malignancies

    John C. Reed;Maurizio Pellecchia

  • Perspectives on NMR in drug discovery: a technique comes of age

    Maurizio Pellecchia;Ivano Bertini;David Cowburn;Claudio Dalvit

  • Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins.

    Shinichi Kitada;Marilisa Leone;Sina Sareth;Dayong Zhai

  • Apoptosis-Inducing Factor Triggered by Poly(ADP-Ribose) Polymerase and Bid Mediates Neuronal Cell Death after Oxygen-Glucose Deprivation and Focal Cerebral Ischemia

    Carsten Culmsee;Changlian Zhu;Stefan Landshamer;Barbara Becattini

  • Role of Excitatory Amino Acid Transporter‐2 (EAAT2) and glutamate in neurodegeneration: Opportunities for developing novel therapeutics

    Keetae Kim;Seok-Geun Lee;Timothy P. Kegelman;Zhao-Zhong Su

  • Cancer Prevention by Tea Polyphenols Is Linked to Their Direct Inhibition of Antiapoptotic Bcl-2-Family Proteins

    Marilisa Leone;Dayong Zhai;Sina Sareth;Shinichi Kitada

  • A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy

    W J Placzek;J Wei;S Kitada;D Zhai

  • Targeting the Bcl-2 family for cancer therapy

    Shibu Thomas;Bridget A Quinn;Swadesh K Das;Rupesh Dash

  • Structural insights into substrate binding by the molecular chaperone DnaK.

    M Pellecchia;D L Montgomery;D L Montgomery;S Y Stevens;C W Vander Kooi

  • Targeting Mcl-1 for the therapy of cancer

    Bridget A Quinn;Rupesh Dash;Belal Azab;Siddik Sarkar

  • NMR structure of the J-domain and the Gly/Phe-rich region of the Escherichia coli DnaJ chaperone

    Maurizio Pellecchia;Thomas Szyperski;Daniel Wall;Costa Georgopoulos

  • Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

    John L. Stebbins;Surya K. De;Thomas Machleidt;Barbara Becattini

  • Rational Design and Real Time, In-Cell Detection of the Proapoptotic Activity of a Novel Compound Targeting Bcl-XL

    Barbara Becattini;Shinichi Kitada;Marilisa Leone;Edward Monosov

  • ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis

    Maria Anna Zipeto;Angela C. Court;Anil Sadarangani;Nathaniel P. Delos Santos

  • A Pan-BCL2 Inhibitor Renders Bone-Marrow-Resident Human Leukemia Stem Cells Sensitive to Tyrosine Kinase Inhibition

    Daniel J. Goff;Angela Court Recart;Anil Sadarangani;Hye Jung Chun

  • Bcl-2 Antiapoptotic Family Proteins and Chemoresistance in Cancer.

    Santanu Maji;Sanjay Panda;Sabindra K. Samal;Omprakash Shriwas

  • Bid-induced release of AIF from mitochondria causes immediate neuronal cell death.

    S Landshamer;M Hoehn;N Barth;S Duvezin-Caubet

  • Efficient synthetic inhibitors of anthrax lethal factor

    Martino Forino;Sherida Johnson;Thiang Y. Wong;Dmitri V. Rozanov

Frequent Co-Authors

John C. Reed
John C. Reed Johnson & Johnson (United States)
Paul B. Fisher
Paul B. Fisher Virginia Commonwealth University
Devanand Sarkar
Devanand Sarkar Virginia Commonwealth University
Tomas Mustelin
Tomas Mustelin University of Washington
Ze'ev Ronai
Ze'ev Ronai Cedars-Sinai Medical Center
Paul Dent
Paul Dent Virginia Commonwealth University
Alex Y. Strongin
Alex Y. Strongin Sanford Burnham Prebys Medical Discovery Institute
Erik R. P. Zuiderweg
Erik R. P. Zuiderweg University of Michigan–Ann Arbor
Elena B. Pasquale
Elena B. Pasquale Discovery Institute
Kurt Wüthrich
Kurt Wüthrich ETH Zurich

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