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Biology and Biochemistry

D-Index
89
Citations
27276
World Ranking
2572
National Ranking
1345

Overview

Tomas Mustelin is a researcher affiliated with the University of Washington in the United States. Their work primarily spans the fields of Medicine and Immunology and Microbiology, with a strong focus on Immunology and Rheumatology as subfields. Mustelin's research covers various topics, notably Systemic Lupus Erythematosus Research, Viral Infections and Immunology Research, and Chromosomal and Genetic Variations, among others.

The scientist has contributed to several recent publications. These include the 2021 paper "Acute skin exposure to ultraviolet light triggers neutrophil-mediated kidney inflammation" published in Proceedings of the National Academy of Sciences, and the 2023 study "Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction" appearing in Scientific Reports. Other notable works are the 2021 paper "Allergic Aspects of IgG4-Related Disease: Implications for Pathogenesis and Therapy" in Frontiers in Immunology, the 2023 article "Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker" in Cancer Discovery, and a 2020 publication "How Retroviruses and Retrotransposons in Our Genome May Contribute to Autoimmunity in Rheumatological Conditions" also published in Frontiers in Immunology.

Mustelin collaborates frequently with several researchers, particularly Xiaoxing Wang, Rayan Najjar, Kennedy C. Ukadike, John LaCava, and Christian Lood. These collaborations have resulted in multiple joint publications.

The scientist's work has been featured often in certain journals, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Scientific Reports
  • Cancer Discovery
  • Arthritis Research & Therapy

Their research topics encompass:

  • Systemic Lupus Erythematosus Research
  • Viral Infections and Immunology Research
  • Chromosomal and Genetic Variations
  • Cytomegalovirus and herpesvirus research
  • T-cell and B-cell Immunology
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • T-cell and Retrovirus Studies

Mustelin's publication record reflects a focus on immunological mechanisms, rheumatological diseases, and molecular biology, which aligns with their selection of research venues and collaborative partnerships.

Best Publications

  • Protein Tyrosine Phosphatases in the Human Genome

    Andres Alonso;Joanna Sasin;Nunzio Bottini;Ilan Friedberg

  • A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

    Nunzio Bottini;Lucia Musumeci;Andres Alonso;Souad Rahmouni

  • Multi-walled carbon nanotubes induce T lymphocyte apoptosis

    Massimo Bottini;Shane Bruckner;Konstantina Nika;Nunzio Bottini

  • Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

    Torkel Vang;Mauro Congia;Maria Doloretta Macis;Lucia Musumeci

  • Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase.

    T Mustelin;K M Coggeshall;A Altman

  • T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation.

    T Mustelin;KM Coggeshall;N Isakov;A Altman

  • The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling

    Virolle T;Adamson Ed;Baron;Birle D

  • Protein tyrosine phosphatases and the immune response.

    Tomas Mustelin;Torkel Vang;Nunzio Bottini

  • Role of PTPN22 in type 1 diabetes and other autoimmune diseases.

    Nunzio Bottini;Torkel Vang;Francesco Cucca;Francesco Cucca;Tomas Mustelin

  • Molecular Events Mediating T Cell Activation

    A Altman;K M Coggeshall;T Mustelin

  • The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.

    M. Bergman;T. Mustelin;C. Oetken;J. Partanen

  • Positive and negative regulation of T-cell activation through kinases and phosphatases.

    Tomas Mustelin;Kjetil Taskén

  • Activation of the Cooh-Terminal Src Kinase (Csk) by Camp-Dependent Protein Kinase Inhibits Signaling through the T Cell Receptor

    Torkel Vang;Knut Martin Torgersen;Vibeke Sundvold;Manju Saxena

  • Cigarette smoke silences innate lymphoid cell function and facilitates an exacerbated type I interleukin-33-dependent response to infection.

    Jennifer Kearley;Jonathan S. Silver;Caroline Sanden;Zheng Liu

  • Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product.

    Marcel Deckert;Sophie Tartare-Deckert;Clément Couture;Tomas Mustelin

  • Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines.

    Mette Nielsen;Keld Kaltoft;Mette Nordahl;Carsten Röpke

  • Cooperative Phosphorylation of the Tumor Suppressor Phosphatase and Tensin Homologue (PTEN) by Casein Kinases and Glycogen Synthase Kinase 3β

    Anna Maria Al-Khouri;Yuliang Ma;Summanuna H. Togo;Scott Williams

  • Dephosphorylation and activation of the T cell tyrosine kinase pp56lck by the leukocyte common antigen (CD45).

    Mustelin T;Altman A

  • Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase.

    Manju Saxena;Scott Williams;Kjetil Taskén;Tomas Mustelin

  • Isolation and Characterization of Fluorescent Nanoparticles from Pristine and Oxidized Electric Arc-Produced Single-Walled Carbon Nanotubes

    Massimo Bottini;Chidambara Balasubramanian;Marcia I Dawson;Antonio Bergamaschi

Frequent Co-Authors

Nunzio Bottini
Nunzio Bottini University of California, San Diego
Leif C. Andersson
Leif C. Andersson University of Helsinki
Maurizio Pellecchia
Maurizio Pellecchia University of California, Riverside
Kjetil Taskén
Kjetil Taskén Oslo University Hospital
Marcia I. Dawson
Marcia I. Dawson Sanford Burnham Prebys Medical Discovery Institute
Amnon Altman
Amnon Altman La Jolla Institute For Allergy & Immunology
Adam Godzik
Adam Godzik University of California, Riverside
Robert C. Rickert
Robert C. Rickert Pfizer (Germany)
Eileen D. Adamson
Eileen D. Adamson Sanford Burnham Prebys Medical Discovery Institute
Roland Kolbeck
Roland Kolbeck AstraZeneca (United Kingdom)

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