D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 66 Citations 12,160 146 World Ranking 3293 National Ranking 1168
Biology and Biochemistry D-index 85 Citations 21,103 238 World Ranking 1374 National Ranking 815

Research.com Recognitions

Awards & Achievements

2002 - Fellow of Alfred P. Sloan Foundation

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Biochemistry

Protein tyrosine phosphatase, Biochemistry, Phosphatase, Phosphorylation and Stereochemistry are his primary areas of study. His research in Protein tyrosine phosphatase intersects with topics in Amino acid, Peptide and Tyrosine phosphorylation. His study in Enzyme, Active site, Binding site, Tyrosine and Kinase is done as part of Biochemistry.

His Phosphatase research incorporates themes from Protein kinase A, Hydrolysis, Peptide sequence, Catalysis and Phosphate. Zhong Yin Zhang usually deals with Phosphorylation and limits it to topics linked to Cancer research and FLT4, Receptor tyrosine kinase and Missense mutation. His work deals with themes such as Residue and Protein structure, which intersect with Stereochemistry.

His most cited work include:

  • Regulation of PTP1B via glutathionylation of the active site cysteine 215. (438 citations)
  • PTP1B as a drug target: recent developments in PTP1B inhibitor discovery (418 citations)
  • Protein Tyrosine Phosphatases: Structure and Function, Substrate Specificity, and Inhibitor Development (360 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Protein tyrosine phosphatase, Biochemistry, Phosphatase, Cancer research and Stereochemistry. His Protein tyrosine phosphatase research includes themes of Tyrosine phosphorylation and Active site. His study in Enzyme, Tyrosine, Small molecule, Binding site and Amino acid are all subfields of Biochemistry.

He combines subjects such as Phosphate, Mutant, Enzyme kinetics and Leaving group with his study of Phosphatase. His research integrates issues of Cancer, Protein kinase B, Leukemia and Cell growth in his study of Cancer research. His work in Stereochemistry tackles topics such as Peptide which are related to areas like Residue.

He most often published in these fields:

  • Protein tyrosine phosphatase (58.91%)
  • Biochemistry (49.14%)
  • Phosphatase (41.95%)

What were the highlights of his more recent work (between 2014-2021)?

  • Cancer research (19.83%)
  • Protein tyrosine phosphatase (58.91%)
  • Phosphatase (41.95%)

In recent papers he was focusing on the following fields of study:

Zhong Yin Zhang spends much of his time researching Cancer research, Protein tyrosine phosphatase, Phosphatase, Biochemistry and Cell biology. The various areas that he examines in his Cancer research study include Cancer, Protein kinase B, Leukemia and Cell growth. His Protein tyrosine phosphatase research integrates issues from Proto-oncogene tyrosine-protein kinase Src, Drug discovery and Tyrosine phosphorylation.

His Phosphatase research incorporates elements of Cell culture, Virtual screening, Escherichia coli, Internal medicine and T-cell leukemia. His work in Two-component regulatory system, Tyrosine and Small molecule are all subfields of Biochemistry research. His Cell biology research includes elements of T cell, Neuroinflammation, Mutant and Microglia.

Between 2014 and 2021, his most popular works were:

  • Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat (215 citations)
  • Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis (83 citations)
  • Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling (81 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Amino acid

The scientist’s investigation covers issues in Protein tyrosine phosphatase, Cancer research, Phosphatase, Biochemistry and Signal transduction. His Protein tyrosine phosphatase study combines topics in areas such as Protein kinase B, Drug discovery and Tyrosine phosphorylation. Zhong Yin Zhang interconnects Cell culture, Cancer, Cell growth, In silico and In vivo in the investigation of issues within Cancer research.

The Phosphatase study combines topics in areas such as Fibrosis and lac operon, Escherichia coli. As a part of the same scientific study, Zhong Yin Zhang usually deals with the Biochemistry, concentrating on Function and frequently concerns with Virtual screening. His biological study deals with issues like Immunology, which deal with fields such as Axon and Low-affinity nerve growth factor receptor.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

PTP1B as a drug target: recent developments in PTP1B inhibitor discovery

Sheng Zhang;Zhong Yin Zhang.
Drug Discovery Today (2007)

607 Citations

Regulation of PTP1B via glutathionylation of the active site cysteine 215.

Barrett Wc;DeGnore Jp;König S;Fales Hm.
Biochemistry (1999)

551 Citations

Protein Tyrosine Phosphatases: Structure and Function, Substrate Specificity, and Inhibitor Development

Zhong Yin Zhang.
Annual Review of Pharmacology and Toxicology (2002)

534 Citations

Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 Å and the complex with tungstate

Jeanne A. Stuckey;Heidi L. Schubert;Eric B. Fauman;Zhong Yin Zhang;Zhong Yin Zhang.
Nature (1994)

491 Citations

Protein tyrosine phosphatases: prospects for therapeutics.

Zhong-Yin Zhang.
Current Opinion in Chemical Biology (2001)

481 Citations

Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: A paradigm for inhibitor design

Yoram A. Puius;Yu Zhao;Michael Sullivan;Michael Sullivan;David S. Lawrence.
Proceedings of the National Academy of Sciences of the United States of America (1997)

479 Citations

Structural and Functional Analysis of the Costimulatory Receptor Programmed Death-1

Xuewu Zhang;Xuewu Zhang;Jean Claude D. Schwartz;Jean Claude D. Schwartz;Xiaoling Guo;Sumeena Bhatia.
Immunity (2004)

441 Citations

Roles of Superoxide Radical Anion in Signal Transduction Mediated by Reversible Regulation of Protein-tyrosine Phosphatase 1B *

William C. Barrett;Jon P. DeGnore;Yen Fang Keng;Zhong Yin Zhang.
Journal of Biological Chemistry (1999)

399 Citations

Protein-tyrosine phosphatases: biological function, structural characteristics, and mechanism of catalysis.

Zhong Yin Zhang.
Critical Reviews in Biochemistry and Molecular Biology (1998)

348 Citations

Dissecting the catalytic mechanism of protein-tyrosine phosphatases.

Zhong-Yin Zhang;Yuan Wang;Jack E. Dixon.
Proceedings of the National Academy of Sciences of the United States of America (1994)

328 Citations

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