2002 - Fellow of Alfred P. Sloan Foundation
Protein tyrosine phosphatase, Biochemistry, Phosphatase, Phosphorylation and Stereochemistry are his primary areas of study. His research in Protein tyrosine phosphatase intersects with topics in Amino acid, Peptide and Tyrosine phosphorylation. His study in Enzyme, Active site, Binding site, Tyrosine and Kinase is done as part of Biochemistry.
His Phosphatase research incorporates themes from Protein kinase A, Hydrolysis, Peptide sequence, Catalysis and Phosphate. Zhong Yin Zhang usually deals with Phosphorylation and limits it to topics linked to Cancer research and FLT4, Receptor tyrosine kinase and Missense mutation. His work deals with themes such as Residue and Protein structure, which intersect with Stereochemistry.
His scientific interests lie mostly in Protein tyrosine phosphatase, Biochemistry, Phosphatase, Cancer research and Stereochemistry. His Protein tyrosine phosphatase research includes themes of Tyrosine phosphorylation and Active site. His study in Enzyme, Tyrosine, Small molecule, Binding site and Amino acid are all subfields of Biochemistry.
He combines subjects such as Phosphate, Mutant, Enzyme kinetics and Leaving group with his study of Phosphatase. His research integrates issues of Cancer, Protein kinase B, Leukemia and Cell growth in his study of Cancer research. His work in Stereochemistry tackles topics such as Peptide which are related to areas like Residue.
Zhong Yin Zhang spends much of his time researching Cancer research, Protein tyrosine phosphatase, Phosphatase, Biochemistry and Cell biology. The various areas that he examines in his Cancer research study include Cancer, Protein kinase B, Leukemia and Cell growth. His Protein tyrosine phosphatase research integrates issues from Proto-oncogene tyrosine-protein kinase Src, Drug discovery and Tyrosine phosphorylation.
His Phosphatase research incorporates elements of Cell culture, Virtual screening, Escherichia coli, Internal medicine and T-cell leukemia. His work in Two-component regulatory system, Tyrosine and Small molecule are all subfields of Biochemistry research. His Cell biology research includes elements of T cell, Neuroinflammation, Mutant and Microglia.
The scientist’s investigation covers issues in Protein tyrosine phosphatase, Cancer research, Phosphatase, Biochemistry and Signal transduction. His Protein tyrosine phosphatase study combines topics in areas such as Protein kinase B, Drug discovery and Tyrosine phosphorylation. Zhong Yin Zhang interconnects Cell culture, Cancer, Cell growth, In silico and In vivo in the investigation of issues within Cancer research.
The Phosphatase study combines topics in areas such as Fibrosis and lac operon, Escherichia coli. As a part of the same scientific study, Zhong Yin Zhang usually deals with the Biochemistry, concentrating on Function and frequently concerns with Virtual screening. His biological study deals with issues like Immunology, which deal with fields such as Axon and Low-affinity nerve growth factor receptor.
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PTP1B as a drug target: recent developments in PTP1B inhibitor discovery
Sheng Zhang;Zhong Yin Zhang.
Drug Discovery Today (2007)
Regulation of PTP1B via glutathionylation of the active site cysteine 215.
Barrett Wc;DeGnore Jp;König S;Fales Hm.
Protein Tyrosine Phosphatases: Structure and Function, Substrate Specificity, and Inhibitor Development
Zhong Yin Zhang.
Annual Review of Pharmacology and Toxicology (2002)
Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 Å and the complex with tungstate
Jeanne A. Stuckey;Heidi L. Schubert;Eric B. Fauman;Zhong Yin Zhang;Zhong Yin Zhang.
Protein tyrosine phosphatases: prospects for therapeutics.
Current Opinion in Chemical Biology (2001)
Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: A paradigm for inhibitor design
Yoram A. Puius;Yu Zhao;Michael Sullivan;Michael Sullivan;David S. Lawrence.
Proceedings of the National Academy of Sciences of the United States of America (1997)
Structural and Functional Analysis of the Costimulatory Receptor Programmed Death-1
Xuewu Zhang;Xuewu Zhang;Jean Claude D. Schwartz;Jean Claude D. Schwartz;Xiaoling Guo;Sumeena Bhatia.
Roles of Superoxide Radical Anion in Signal Transduction Mediated by Reversible Regulation of Protein-tyrosine Phosphatase 1B *
William C. Barrett;Jon P. DeGnore;Yen Fang Keng;Zhong Yin Zhang.
Journal of Biological Chemistry (1999)
Protein-tyrosine phosphatases: biological function, structural characteristics, and mechanism of catalysis.
Zhong Yin Zhang.
Critical Reviews in Biochemistry and Molecular Biology (1998)
Dissecting the catalytic mechanism of protein-tyrosine phosphatases.
Zhong-Yin Zhang;Yuan Wang;Jack E. Dixon.
Proceedings of the National Academy of Sciences of the United States of America (1994)
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