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Michel L. Tremblay

Michel L. Tremblay

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Biology and Biochemistry
Canada
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
88
Citations
26835
World Ranking
2709
National Ranking
83

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Canada Leader Award

Overview

Michel L. Tremblay is affiliated with McGill University in Canada. Their research spans key areas within biochemistry, genetics, and molecular biology, with significant contributions also in the field of medicine.

The main research fields include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these broad areas, their subfields of study focus on:

  • Molecular Biology
  • Immunology
  • Physiology
  • Surgery
  • Nutrition and Dietetics

Michel L. Tremblay has studied a range of molecular and cellular mechanisms, particularly concentrating on protein tyrosine phosphatases and their roles in disease processes. Their main research topics are:

  • Protein Tyrosine Phosphatases
  • Galectins and Cancer Biology
  • RNA modifications and cancer
  • Magnesium in Health and Disease
  • Gut microbiota and health
  • Parathyroid Disorders and Treatments
  • RNA regulation and disease

Among their recent scientific publications are:

  • Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal, 2020, Science Advances
  • Lesch-Nyhan disease causes impaired energy metabolism and reduced developmental potential in midbrain dopaminergic cells, 2021, Stem Cell Reports
  • T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling, 2021, Journal of Clinical Investigation
  • Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage, 2022, Nature Communications
  • ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs, 2021, Cellular and Molecular Life Sciences

The frequent co-authors who have collaborated extensively with Michel L. Tremblay include:

  • Isabelle Aubry
  • Alexandre Poirier
  • Yevgen Zolotarov
  • Serge Hardy
  • Marianne R. Spalinger

Their research has been published multiple times in prominent venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • The FASEB Journal
  • Journal of Clinical Investigation
  • Nature Communications

Best Publications

  • Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.

    Mounib Elchebly;Paul Payette;Eva Michaliszyn;Wanda Cromlish

  • The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.

    S Vidal;M L Tremblay;G Govoni;S Gauthier

  • Targeted ablation of the 25-hydroxyvitamin D 1α-hydroxylase enzyme: Evidence for skeletal, reproductive, and immune dysfunction

    Dibyendu K. Panda;Dengshun Miao;Michel L. Tremblay;Jacinthe Sirois

  • Attenuation of Leptin Action and Regulation of Obesity by Protein Tyrosine Phosphatase 1B

    Alan Cheng;Noriko Uetani;Paul D. Simoncic;Paul D. Simoncic;Vikas P. Chaubey

  • TYK2 and JAK2 Are Substrates of Protein-tyrosine Phosphatase 1B

    Michael P. Myers;Jannik N. Andersen;Alan Cheng;Michel L. Tremblay

  • Identification of a Nuclear Stat1 Protein Tyrosine Phosphatase

    Johanna ten Hoeve;Maria de Jesus Ibarra-Sanchez;Yubin Fu;Wei Zhu

  • Inside the human cancer tyrosine phosphatome

    Sofi G. Julien;Nadia Dubé;Serge Hardy;Michel L. Tremblay

  • Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1

    Kyoko Tsukiyama-Kohara;Francis Poulin;Michinori Kohara;Christine T. DeMaria

  • Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice

    Kong E. You-Ten;Eric S. Muise;Annick Itié;Eva Michaliszyn

  • The T Cell Protein Tyrosine Phosphatase Is a Negative Regulator of Janus Family Kinases 1 and 3

    Paul D. Simoncic;Paul D. Simoncic;Ailsa Lee-Loy;Dwayne L. Barber;Dwayne L. Barber;Michel L. Tremblay

  • Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis.

    Sofi G Julien;Nadia Dubé;Nadia Dubé;Michelle Read;Janice Penney

  • Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts.

    Alexandre Angers-Loustau;Jean-François Côté;Alain Charest;Donald Dowbenko

  • Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol.

    Regina Cencic;Marilyn Carrier;Gabriela Galicia-Vázquez;Marie Eve Bordeleau

  • Animal model of Gaucher's disease from targeted disruption of the mouse glucocerebrosidase gene.

    V. L. J. Tybulewicz;V. L. J. Tybulewicz;M. L. Tremblay;M. L. Tremblay;LaMarca;R. Willemsen

  • Hindlimb patterning and mandible development require the Ptx1 gene.

    Christian Lanctôt;Alain Moreau;Michel Chamberland;Michel L. Tremblay

  • Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila

    Eduardo Diez;Seung-Hwan Lee;Susan Gauthier;Zahra Yaraghi

  • Mesenchymal stromal cell-derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction.

    Moutih Rafei;Jeremy Hsieh;Simon Fortier;MengYang Li

  • Cytoplasmic protein tyrosine phosphatases, regulation and function: the roles of PTP1B and TC-PTP.

    Annie Bourdeau;Nadia Dubé;Michel L Tremblay

  • T cell development in mice that lack the zeta chain of the T cell antigen receptor complex

    Paul E. Love;Elizabeth W. Shores;Mark D. Johnson;Michel L. Tremblay

  • Protein-tyrosine Phosphatase 1B Potentiates IRE1 Signaling during Endoplasmic Reticulum Stress

    Feng Gu;Duc Thang Nguyên;Matthew Stuible;Nadia Dubé

Frequent Co-Authors

Tony Tiganis
Tony Tiganis Peter MacCallum Cancer Centre
Morag Park
Morag Park McGill University
Brian P. Kennedy
Brian P. Kennedy MSD (United States)
Martin Olivier
Martin Olivier McGill University
Jerry Pelletier
Jerry Pelletier McGill University
William J. Muller
William J. Muller McGill University
Nahum Sonenberg
Nahum Sonenberg McGill University
Timothy E. Kennedy
Timothy E. Kennedy Montreal Neurological Institute and Hospital
James Borneman
James Borneman University of California, Riverside
Andreas Bikfalvi
Andreas Bikfalvi University of Bordeaux

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