World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
107
Citations
50392
World Ranking
1086
National Ranking
654

Research.com Recognitions

  • 2001 - Fellow of the Royal Society, United Kingdom

Overview

Nicholas K. Tonks is affiliated with Cold Spring Harbor Laboratory in the United States. Their research contributions span multiple fields including Biochemistry, Genetics and Molecular Biology, Immunology and Microbiology, and Medicine. The main subfields of study in their work include Molecular Biology, Immunology, Oncology, Nutrition and Dietetics, and Surgery.

The scientist's work frequently addresses topics related to Protein Tyrosine Phosphatases, Galectins and Cancer Biology, Cancer Immunotherapy and Biomarkers, Neutrophil, Myeloperoxidase and Oxidative Mechanisms, Trace Elements in Health, Ferroptosis and cancer prognosis, and Drug Transport and Resistance Mechanisms.

Key recent papers authored by Nicholas K. Tonks include:

  • Connecting copper and cancer: from transition metal signalling to metalloplasia, 2021, Nature Reviews. Cancer
  • PTP1B Is an Intracellular Checkpoint that Limits T-cell and CAR T-cell Antitumor Immunity, 2021, Cancer Discovery
  • PTP1B inhibitors protect against acute lung injury and regulate CXCR4 signaling in neutrophils, 2022, JCI Insight
  • Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation, 2020, Journal of Biological Chemistry
  • Mito-oncology agent: fermented extract suppresses the Warburg effect, restores oxidative mitochondrial activity, and inhibits in vivo tumor growth, 2020, Scientific Reports

The scientist has collaborated frequently with several researchers, including Darryl Pappin, Linda Van Aelst, Tony Tiganis, Dongyan Song, and Gyula Bencze.

Publication venues where Nicholas K. Tonks has most regularly contributed include bioRxiv (Cold Spring Harbor Laboratory), Journal of Biological Chemistry, Scientific Reports, Nature Reviews. Cancer, and Cancer Discovery.

In recognition of their scientific contributions, Nicholas K. Tonks was awarded the title of Fellow of the Royal Society, United Kingdom, in 2001.

Best Publications

  • Protein tyrosine phosphatases: from genes, to function, to disease

    Nicholas K Tonks

  • The lipid phosphatase activity of PTEN is critical for its tumor supressor function

    M. P. Myers;I. Pass;I. H. Batty;J. Van der Kaay

  • Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

    Neil G. Anderson;James L. Maller;Nicholas K. Tonks;Thomas W. Sturgill

  • MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

    Hong Sun;Catherine H. Charles;Lester F. Lau;Nicholas K. Tonks

  • Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes

    EH Fischer;H Charbonneau;NK Tonks

  • Reversible Oxidation and Inactivation of Protein Tyrosine Phosphatases In Vivo

    Tzu-Ching Meng;Toshiyuki Fukada;Nicholas K Tonks

  • Connecting copper and cancer: from transition metal signalling to metalloplasia.

    Eva J Ge;Ashley I Bush;Angela Casini;Paul A Cobine

  • Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

    Annette Salmeen;Jannik N. Andersen;Michael P. Myers;Tzu-Ching Meng

  • P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

    Michael P. Myers;Javor P. Stolarov;Charis Eng;Jing Li

  • Protein tyrosine phosphatases in signal transduction.

    Benjamin G Neel;Nicholas K Tonks

  • Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases

    Andrew J. Flint;Tony Tiganis;David Barford;Nicholas K. Tonks

  • Crystal structure of human protein tyrosine phosphatase 1B.

    David Barford;Andrew J. Flint;Nicholas K. Tonks

  • Redox redux: revisiting PTPs and the control of cell signaling

    Nicholas K. Tonks

  • Structural and Evolutionary Relationships among Protein Tyrosine Phosphatase Domains

    Jannik N. Andersen;Ole H. Mortensen;Günther H. Peters;Paul G. Drake

  • Increase of the catalytic activity of phospholipase C-gamma 1 by tyrosine phosphorylation.

    Shunzo Nishibe;Matthew I. Wahl;S. M. Hernandez-Sotomayor;Nicholas K. Tonks

  • Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B.

    Zongchao Jia;David Barford;Andrew J. Flint;Nicholas K. Tonks

  • Purification of the major protein-tyrosine-phosphatases of human placenta.

    N K Tonks;C D Diltz;E H Fischer

  • Characterization of the major protein-tyrosine-phosphatases of human placenta.

    N K Tonks;C D Diltz;E H Fischer

  • From form to function: signaling by protein tyrosine phosphatases.

    Nicholas K Tonks;Benjamin G Neel

  • The FERM domain: A unique module involved in the linkage of cytoplasmic proteins to the membrane

    Athar H. Chishti;Anthony C. Kim;Shirin M. Marfatia;Mohini Lutchman

Frequent Co-Authors

David Barford
David Barford MRC Laboratory of Molecular Biology
Edmond H. Fischer
Edmond H. Fischer University of Washington
Darryl J. Pappin
Darryl J. Pappin Cold Spring Harbor Laboratory
Harry Charbonneau
Harry Charbonneau Purdue University West Lafayette
Tony Tiganis
Tony Tiganis Peter MacCallum Cancer Centre
Edwin G. Krebs
Edwin G. Krebs University of Washington
Benjamin G. Neel
Benjamin G. Neel New York University Langone Medical Center
Kenneth A. Walsh
Kenneth A. Walsh University of Washington
Toshiyuki Fukada
Toshiyuki Fukada Tokushima Bunri University
James D. Watson
James D. Watson Cold Spring Harbor Laboratory

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