D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 107 Citations 45,753 223 World Ranking 774 National Ranking 503

Research.com Recognitions

Awards & Achievements

2005 - Member of Academia Europaea

2002 - Fellow of the American Association for the Advancement of Science (AAAS)

1995 - Member of the National Academy of Sciences

1987 - Fellow of the American Academy of Arts and Sciences

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • DNA

His main research concerns Biochemistry, Ubiquitin, N-end rule, Saccharomyces cerevisiae and Cell biology. Biochemistry is represented through his Protein degradation, Mutant, Arginine, DNA and Degron research. His biological study spans a wide range of topics, including Protein structure and Cell cycle.

His studies deal with areas such as Lysine, Proteolysis, Peptide sequence, Cysteine and Arginyltransferase as well as N-end rule. Alexander Varshavsky has included themes like Amino acid, Gene product and Dihydrofolate reductase in his Saccharomyces cerevisiae study. His work deals with themes such as Molecular biology, HSPA2 and Ribosomal protein, which intersect with Cell biology.

His most cited work include:

  • In Vivo Half-Life of a Protein is a Function of its Amino-Terminal Residue (1580 citations)
  • A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. (1188 citations)
  • The N-end rule: functions, mysteries, uses (795 citations)

What are the main themes of his work throughout his whole career to date?

Alexander Varshavsky mainly focuses on Biochemistry, Ubiquitin, N-end rule, Saccharomyces cerevisiae and Ubiquitin ligase. His study in Protein degradation, Proteolysis, Amino acid, Degron and Peptide sequence falls within the category of Biochemistry. The various areas that he examines in his Ubiquitin study include Proteases, Cell biology, Proteasome and Protein subunit.

The study incorporates disciplines such as Molecular biology and Arginine, Arginyltransferase, Protein arginylation in addition to N-end rule. His studies in Saccharomyces cerevisiae integrate themes in fields like Gene product and Mutant. His Ubiquitin ligase research incorporates themes from Deubiquitinating enzyme and Ribosome.

He most often published in these fields:

  • Biochemistry (55.56%)
  • Ubiquitin (38.46%)
  • N-end rule (38.46%)

What were the highlights of his more recent work (between 2010-2020)?

  • N-end rule (38.46%)
  • Biochemistry (55.56%)
  • Ubiquitin (38.46%)

In recent papers he was focusing on the following fields of study:

Alexander Varshavsky mostly deals with N-end rule, Biochemistry, Ubiquitin, Degron and Ubiquitin ligase. His research integrates issues of Amino acid, Methionine, Molecular biology, Cell biology and Arginyltransferase in his study of N-end rule. His study in Proteolysis, Saccharomyces cerevisiae, Protein degradation, Protein subunit and Acetylation is carried out as part of his studies in Biochemistry.

His Ubiquitin research includes elements of Johanson–Blizzard syndrome, Frameshift mutation, Proteasome, DNA repair and Deamidation. His Degron research integrates issues from Membrane, Transcription factor, Ribosome and Cytosol. His biological study spans a wide range of topics, including RGS Proteins, RGS2, Endoplasmic reticulum, Membrane protein and Gq alpha subunit.

Between 2010 and 2020, his most popular works were:

  • The N-end rule pathway and regulation by proteolysis (443 citations)
  • The Ubiquitin System, an Immense Realm (212 citations)
  • Control of Protein Quality and Stoichiometries by N-Terminal Acetylation and the N-End Rule Pathway (191 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • DNA

The scientist’s investigation covers issues in N-end rule, Biochemistry, Ubiquitin ligase, Proteolysis and Ubiquitin. His N-end rule research incorporates elements of Protein degradation, Cell biology, Protein subunit, Sequence motif and Peptide sequence. His Protein degradation research is multidisciplinary, incorporating perspectives in Autophagy, Amino acid, Genetic code, Ubiquitin-conjugating enzyme and Computational biology.

His studies deal with areas such as Protein kinase C, Saccharomyces cerevisiae and Fructose 1,6-bisphosphatase as well as Sequence motif. Alexander Varshavsky focuses mostly in the field of Ubiquitin ligase, narrowing it down to topics relating to Acetylation and, in certain cases, Methionine, Protein folding, Protein Sorting Signals and Ribosome. As a member of one scientific family, Alexander Varshavsky mostly works in the field of Ubiquitin, focusing on Proteasome and, on occasion, Intracellular, Proteases and Proteotoxicity.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

In Vivo Half-Life of a Protein is a Function of its Amino-Terminal Residue

Andreas Bachmair;Daniel Finley;Alexander Varshavsky.
Science (1986)

2349 Citations

A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein.

Vincent Chau;John W. Tobias;Andreas Bachmair;Andreas Bachmair;David Marriott.
Science (1989)

1800 Citations

The N-end rule: functions, mysteries, uses

Alexander Varshavsky.
Proceedings of the National Academy of Sciences of the United States of America (1996)

1233 Citations

A proteolytic pathway that recognizes ubiquitin as a degradation signal.

Erica S. Johnson;Philip C.M. Ma;Irene M. Ota;Alexander Varshavsky.
Journal of Biological Chemistry (1995)

1112 Citations

The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses

Daniel Finley;Engin Özkaynak;Alexander Varshavsky.
Cell (1987)

1075 Citations

Split ubiquitin as a sensor of protein interactions in vivo

Nils Johnsson;Alexander Varshavsky.
Proceedings of the National Academy of Sciences of the United States of America (1994)

1051 Citations

The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme

Stefan Jentsch;John P. McGrath;Alexander Varshavsky.
Nature (1987)

953 Citations

The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis.

Daniel Finley;Bonnie Bartel;Alexander Varshavsky.
Nature (1989)

879 Citations

Basic Medical Research Award. The ubiquitin system.

Avram Hershko;Aaron Ciechanover;Alexander Varshavsky.
Nature Medicine (2000)

792 Citations

The ubiquitin system

Alexander Varshavsky.
Trends in Biochemical Sciences (1997)

787 Citations

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