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Biology and Biochemistry

D-Index
96
Citations
44378
World Ranking
1794
National Ranking
990

Overview

Daniel Finley is affiliated with Harvard University in the United States, contributing to the fields of Biochemistry, Genetics, and Molecular Biology, as well as Medicine.

Their research spans several subfields including Molecular Biology, Epidemiology, Cellular and Molecular Neuroscience, Genetics, and Hematology.

Main research topics addressed in their work include:

  • Ubiquitin and proteasome pathways
  • Autophagy in Disease and Therapy
  • Genetic Neurodegenerative Diseases
  • Genetics and Neurodevelopmental Disorders
  • Acute Myeloid Leukemia Research
  • Epigenetics and DNA Methylation
  • Genomics and Chromatin Dynamics

Frequent publication venues for their work include:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • iScience
  • Biochemistry
  • Alzheimer s & Dementia

Recent papers authored or co-authored by Daniel Finley are:

  • Chromatin accessibility promotes hematopoietic and leukemia stem cell activity, 2020, Nature Communications
  • Global proteome metastability response in isogenic animals to missense mutations and polyglutamine expansions in aging, 2022, bioRxiv (Cold Spring Harbor Laboratory)
  • Ubiquitin Linkage Specificity of Deubiquitinases Determines Cyclophilin Nuclear Localization and Degradation, 2020, iScience
  • A General in Vitro Assay for Studying Enzymatic Activities of the Ubiquitin System, 2020, Biochemistry
  • Exploring lysosomal defects and rescue strategies for Alzheimer's disease using human transdifferentiated neurons, 2022, Alzheimer s & Dementia

Key frequent co-authors collaborating with Daniel Finley include:

  • Miguel A. Prado
  • João A. Paulo
  • Steven P. Gygi
  • Lucía Cabal-Hierro
  • Peter van Galen

Best Publications

  • In Vivo Half-Life of a Protein is a Function of its Amino-Terminal Residue

    Andreas Bachmair;Daniel Finley;Alexander Varshavsky

  • Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

    Daniel Finley

  • A proteomics approach to understanding protein ubiquitination

    Junmin Peng;Junmin Peng;Daniel Schwartz;Joshua E Elias;Carson C Thoreen

  • Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation.

    Ping Xu;Duc M. Duong;Nicholas T. Seyfried;Dongmei Cheng

  • A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.

    Michael H Glickman;David M Rubin;Olivier Coux;Inge Wefes

  • Enhancement of proteasome activity by a small-molecule inhibitor of USP14

    Byung Hoon Lee;Min Jae Lee;Soyeon Park;Dong Chan Oh;Dong Chan Oh

  • The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses

    Daniel Finley;Engin Özkaynak;Alexander Varshavsky

  • A gated channel into the proteasome core particle.

    Michael Groll;Monica Bajorek;Alwin Köhler;Luis Moroder

  • The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis.

    Daniel Finley;Bonnie Bartel;Alexander Varshavsky

  • Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

    Pedro M. Quirós;Miguel A. Prado;Nicola Zamboni;Davide D’Amico

  • Multiple Associated Proteins Regulate Proteasome Structure and Function

    David S. Leggett;John Hanna;Anna Borodovsky;Bernat Crosas

  • Proteasome subunit Rpn13 is a novel ubiquitin receptor

    Koraljka Husnjak;Suzanne Elsasser;Naixia Zhang;Xiang Chen

  • A ubiquitin mutant with specific defects in DNA repair and multiubiquitination.

    J Spence;S Sadis;A L Haas;D Finley

  • Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85

    Aaron Ciechanover;Daniel Finley;Alexander Varshavsky

  • Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

    Daniel Finley;Aaron Ciechanover;Alexander Varshavsky

  • The Regulatory Particle of the Saccharomyces cerevisiae Proteasome

    Michael H. Glickman;David M. Rubin;Victor A. Fried;Daniel Finley

  • The base of the proteasome regulatory particle exhibits chaperone-like activity.

    Beate C. Braun;Michael Glickman;Regine Kraft;Burkhardt Dahlmann

  • Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.

    Ernst Jarosch;Christof Taxis;Corinna Volkwein;Javier Bordallo

  • Docking of the Proteasomal ATPases' Carboxyl Termini in the 20S Proteasome's α Ring Opens the Gate for Substrate Entry

    David M. Smith;Shih-Chung Chang;Soyeon Park;Daniel Finley

  • MHC-linked LMP gene products specifically alter peptidase activities of the proteasome

    James Driscoll;Michael G. Brown;Daniel Finley;John J. Monaco

Frequent Co-Authors

Steven P. Gygi
Steven P. Gygi Harvard University
Randall W. King
Randall W. King Harvard University
David T. Rubin
David T. Rubin University of Chicago
Michael H. Glickman
Michael H. Glickman Technion – Israel Institute of Technology
Joao A. Paulo
Joao A. Paulo Harvard University
David Klenerman
David Klenerman University of Cambridge
Alfred L. Goldberg
Alfred L. Goldberg Harvard University
Richard D. Vierstra
Richard D. Vierstra Washington University in St. Louis
Alexander Varshavsky
Alexander Varshavsky California Institute of Technology

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