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Chemistry

D-Index
87
Citations
28754
World Ranking
2394
National Ranking
119

Research.com Recognitions

  • 2022 - Breakthrough Prize in Life Sciences for the development of a robust and affordable method to determine DNA sequences on a massive scale, which has transformed the practice of science and medicine.
  • 2012 - Fellow of the Royal Society, United Kingdom
  • 2007 - Interdisciplinary Prize, Royal Society of Chemistry (UK)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

David Klenerman is affiliated with the University of Cambridge in the United Kingdom. Their research contributions primarily span the fields of biochemistry, genetics, molecular biology, and medicine, with a significant focus on molecular biology, physiology, neurology, biophysics, and biomedical engineering.

Klenerman's work addresses several specialized topics within the life sciences, including:

  • Alzheimer's disease research and treatments
  • Advanced fluorescence microscopy techniques
  • Parkinson's disease mechanisms and treatments
  • Prion diseases and protein misfolding
  • Neuroinflammation and neurodegeneration mechanisms
  • Monoclonal and polyclonal antibodies research
  • Advanced electron microscopy techniques and applications

Their frequent collaborators include Steven F. Lee, Tuomas P. J. Knowles, Jeff Y. L. Lam, Georg Meisl, and John S. H. Danial, reflecting extensive interdisciplinary cooperation.

Klenerman has published regularly in key scientific venues. Popular journals and repositories for their publications include bioRxiv (Cold Spring Harbor Laboratory), Biophysical Journal, Nature Communications, Zenodo (CERN European Organization for Nuclear Research), and Alzheimer's & Dementia.

Some of their recent papers are:

  • Single-molecule visualization of DNA G-quadruplex formation in live cells, 2020, Nature Chemistry
  • Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation, 2020, Cell Death and Differentiation
  • Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity, 2022, Nature Neuroscience
  • Small soluble α-synuclein aggregates are the toxic species in Parkinson's disease, 2022, Nature Communications
  • Kinetic diversity of amyloid oligomers, 2020, Proceedings of the National Academy of Sciences

David Klenerman has been recognized by several awards, including the Breakthrough Prize in Life Sciences in 2022 for the development of a robust and affordable method to determine DNA sequences on a massive scale, which has transformed the practice of science and medicine. They were also elected Fellow of the Royal Society in the United Kingdom in 2012, and received the Interdisciplinary Prize from the Royal Society of Chemistry (UK) in 2007. Additionally, Klenerman is a Fellow of The Academy of Medical Sciences in the United Kingdom.

Best Publications

  • Accurate whole human genome sequencing using reversible terminator chemistry

    David R. Bentley;Shankar Balasubramanian;Harold P. Swerdlow;Harold P. Swerdlow;Geoffrey P. Smith

  • Direct observation of the interconversion of normal and toxic forms of α-synuclein.

    Nunilo Cremades;Samuel I.A. Cohen;Emma Deas;Andrey Y. Abramov

  • FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

    Seema Qamar;Guo Zhen Wang;Suzanne J. Randle;Francesco Simone Ruggeri

  • Arrayed biomolecules and their use in sequencing

    Shankar Balasubramanian;David Klenerman;Colin Barnes;Mark Allen Osborne

  • Nanoscale live-cell imaging using hopping probe ion conductance microscopy.

    Pavel Novak;Chao Li;Andrew I Shevchuk;Ruben Stepanyan

  • Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

    Serene W. Chen;Srdja Drakulic;Emma Deas;Myriam Ouberai

  • α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.

    Marthe H. R. Ludtmann;Marthe H. R. Ludtmann;Plamena R. Angelova;Mathew H. Horrocks;Mathew H. Horrocks;Minee L. Choi;Minee L. Choi

  • Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

    Suman De;David C. Wirthensohn;Patrick Flagmeier;Craig Hughes

  • Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer

    Liming Ying;Jeremy J. Green;Haitao Li;David Klenerman

  • Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

    Emma Deas;Nunilo Cremades;Plamena R. Angelova;Marthe H.R. Ludtmann

  • Single-molecule visualization of DNA G-quadruplex formation in live cells

    Marco Di Antonio;Marco Di Antonio;Aleks Ponjavic;Aleks Ponjavic;Antanas Radzevičius;Rohan T. Ranasinghe

  • The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β 1−40 peptide

    Priyanka Narayan;Angel Orte;Angel Orte;Richard W Clarke;Benedetta Bolognesi

  • Multifunctional nanoprobes for nanoscale chemical imaging and localized chemical delivery at surfaces and interfaces.

    Yasufumi Takahashi;Andrew I. Shevchuk;Pavel Novak;Yanjun Zhang

  • Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation

    Plamena R. Angelova;Minee L. Choi;Minee L. Choi;Alexey V. Berezhnov;Mathew H. Horrocks;Mathew H. Horrocks

  • Direct and sensitive detection of a human virus by rupture event scanning

    Matthew A. Cooper;Fedor N. Dultsev;Tony Minson;Victor P. Ostanin

  • Electrochemical Nanoprobes for Single-Cell Analysis

    Paolo Actis;Sergiy Tokar;Jan Clausmeyer;Babak Babakinejad

  • Ultrasensitive coincidence fluorescence detection of single DNA molecules.

    Haitao Li;Liming Ying;Jeremy J. Green;Shankar Balasubramanian

  • Topographical and electrochemical nanoscale imaging of living cells using voltage-switching mode scanning electrochemical microscopy

    Yasufumi Takahashi;Andrew I. Shevchuk;Pavel Novak;Babak Babakinejad

  • Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

    Marija Iljina;Gonzalo A. Garcia;Mathew H. Horrocks;Laura Tosatto

  • A Reversible pH-Driven DNA Nanoswitch Array

    Dongsheng Liu;Andreas Bruckbauer;Chris Abell;Shankar Balasubramanian

  • Ultrarapid generation of femtoliter microfluidic droplets for single-molecule-counting immunoassays.

    Jung-uk Shim;Rohan T. Ranasinghe;Clive A. Smith;Shehu M. Ibrahim

  • Writing with DNA and protein using a nanopipet for controlled delivery.

    Andreas Bruckbauer;Liming Ying;Alison M. Rothery;Dejian Zhou

  • The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-beta 1-40 peptide

    Priyanka Narayan;Angel Orte;Richard W Clarke;Benedetta Bolognesi

Frequent Co-Authors

Christopher M. Dobson
Christopher M. Dobson University of Cambridge
Tuomas P. J. Knowles
Tuomas P. J. Knowles University of Cambridge
Simon J. Davis
Simon J. Davis University of Oxford
Shankar Balasubramanian
Shankar Balasubramanian University of Cambridge
Chris Abell
Chris Abell University of Cambridge
Dejian Zhou
Dejian Zhou University of Leeds
Andrey Y. Abramov
Andrey Y. Abramov University College London
Clare E. Bryant
Clare E. Bryant University of Cambridge
Peter St George-Hyslop
Peter St George-Hyslop Columbia University
Ernest D. Laue
Ernest D. Laue University of Cambridge

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