World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
105
Citations
45685
World Ranking
992
National Ranking
50

Research.com Recognitions

  • 2017 - Corday–Morgan Prize, Royal Society of Chemistry (UK)
  • 2012 - Harrison-Meldola Memorial Prize, Royal Society of Chemistry (UK)

Overview

Tuomas P. J. Knowles is affiliated with the University of Cambridge in the United Kingdom. Their research spans multiple fields including Biochemistry, Genetics and Molecular Biology, and Medicine, with significant contributions particularly in Molecular Biology, Biomedical Engineering, Physiology, Biomaterials, and Neurology.

The scientist's work covers a variety of main topics, such as Alzheimer's disease research and treatments, Protein Structure and Dynamics, RNA Research and Splicing, Supramolecular Self-Assembly in Materials, Prion Diseases and Protein Misfolding, Innovative Microfluidic and Catalytic Techniques Innovation, and Microfluidic and Capillary Electrophoresis Applications.

Tuomas P. J. Knowles has published extensively in several research venues. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biophysical Journal
  • Proceedings of the National Academy of Sciences
  • Nature Communications
  • ACS Nano

Recent notable papers by Tuomas P. J. Knowles include:

  • "Biomimetic peptide self-assembly for functional materials," 2020, Nature Reviews Chemistry
  • "Half a century of amyloids: past, present and future," 2020, Chemical Society Reviews
  • "Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions," 2021, Nature Communications
  • "Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide," 2020, Nature Chemistry
  • "Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions," 2022, Proceedings of the National Academy of Sciences

Among frequent collaborators, Tuomas P. J. Knowles has worked with:

  • Georg Meisl (85 copublications)
  • Michele Vendruscolo (79 copublications)
  • Georg Krainer (54 copublications)
  • Sara Linse (50 copublications)
  • Zenon Toprakcioglu (48 copublications)

The scientist has received recognition for their work through awards such as the Corday-Morgan Prize from the Royal Society of Chemistry (UK) in 2017 and the Harrison-Meldola Memorial Prize from the same society in 2012.

Best Publications

  • The amyloid state and its association with protein misfolding diseases

    Tuomas P. J. Knowles;Michele Vendruscolo;Christopher M. Dobson

  • Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

    Samuel I. A. Cohen;Sara Linse;Leila M. Luheshi;Erik Hellstrand

  • An analytical solution to the kinetics of breakable filament assembly

    Tuomas P. J. Knowles;Christopher A. Waudby;Glyn L. Devlin;Samuel I. A. Cohen

  • Direct observation of the interconversion of normal and toxic forms of α-synuclein.

    Nunilo Cremades;Samuel I.A. Cohen;Emma Deas;Andrey Y. Abramov

  • FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

    Seema Qamar;Guo Zhen Wang;Suzanne J. Randle;Francesco Simone Ruggeri

  • Role of intermolecular forces in defining material properties of protein nanofibrils.

    Tuomas P. Knowles;Anthony W. Fitzpatrick;Sarah Meehan;Helen R. Mott

  • Nanomechanics of functional and pathological amyloid materials

    Tuomas P. J. Knowles;Markus J. Buehler

  • On the lag phase in amyloid fibril formation

    Paolo Arosio;Tuomas Pertti Knowles;Sara Linse

  • Molecular mechanisms of protein aggregation from global fitting of kinetic models

    Georg Meisl;Julius B Kirkegaard;Paolo Arosio;Thomas C T Michaels

  • Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

    Alexander K. Buell;Céline Galvagnion;Ricardo Gaspar;Emma Sparr

  • Characterization of the nanoscale properties of individual amyloid fibrils.

    Jeffrey F. Smith;Tuomas P. J. Knowles;Christopher M. Dobson;Cait E. MacPhee

  • Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

    Céline Galvagnion;Alexander K Buell;Georg Meisl;Thomas C T Michaels

  • Atomic structure and hierarchical assembly of a cross-β amyloid fibril

    Anthony W. P. Fitzpatrick;Galia T. Debelouchina;Marvin J. Bayro;Daniel K. Clare

  • Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

    Georg Meisl;Xiaoting Yang;Erik Hellstrand;Birgitta Frohm

  • Amyloid Fibrils as Building Blocks for Natural and Artificial Functional Materials.

    Tuomas P. J. Knowles;Raffaele Mezzenga

  • From macroscopic measurements to microscopic mechanisms of protein aggregation.

    Samuel I.A. Cohen;Michele Vendruscolo;Christopher M. Dobson;Tuomas P.J. Knowles

  • Half a century of amyloids: past, present and future

    Pu Chun Ke;Pu Chun Ke;Ruhong Zhou;Ruhong Zhou;Louise C. Serpell;Roland Riek

  • A High Power-Density, Mediator-Free, Microfluidic Biophotovoltaic Device for Cyanobacterial Cells.

    Paolo Bombelli;Thomas Müller;Therese W. Herling;Christopher J. Howe

  • RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether.

    Ya-Cheng Liao;Michael S. Fernandopulle;Guozhen Wang;Heejun Choi

  • Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

    Serene W. Chen;Srdja Drakulic;Emma Deas;Myriam Ouberai

  • Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

    Georg Krainer;Timothy J. Welsh;Jerelle A. Joseph;Jorge R. Espinosa

  • Metastability of native proteins and the phenomenon of amyloid formation.

    Andrew J. Baldwin;Tuomas P. J. Knowles;Gian Gaetano Tartaglia;Anthony W. Fitzpatrick

  • Erratum: The amyloid state and its association with protein misfolding diseases

    Tuomas P. J. Knowles;Michele Vendruscolo;Christopher M. Dobson

Frequent Co-Authors

Christopher M. Dobson
Christopher M. Dobson University of Cambridge
Michele Vendruscolo
Michele Vendruscolo University of Cambridge
Sara Linse
Sara Linse Lund University
Paolo Arosio
Paolo Arosio ETH Zurich
David Klenerman
David Klenerman University of Cambridge
Mark E. Welland
Mark E. Welland University of Cambridge
Ehud Gazit
Ehud Gazit Tel Aviv University
Peter St George-Hyslop
Peter St George-Hyslop Columbia University
Gonçalo J. L. Bernardes
Gonçalo J. L. Bernardes University of Cambridge
Adriano Aguzzi
Adriano Aguzzi University of Zurich

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